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Mitochondrial Genomes of the Ciliates
1992Publisher Summary This chapter describes the mithochondrial genome of ciliates, with emphasis on Paramecium and Tetrahymena . Both Paramecium and Tetrahymena have linear genomes with unique replicative pathways. The mitochondrial genome of Paramecium aurelia is a linear duplex.
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Evidence that the mitochondrial genome is the thrifty genome
Diabetes Research and Clinical Practice, 1999Although mitochondrial DNA (mtDNA) abnormalities are known to cause insulin deficiency, insulin resistance and diabetes mellitus, it's quantitative aspect was not addressed well. In this review, mitochondrial genome hypothesis of thrifty phenomenon is proposed, based on the data and review of literatures. From a population based epidemiologic study, it
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Regulation and function of the mitochondrial genome
Journal of Inherited Metabolic Disease, 1996SummaryMolecular changes in human mitochondrial DNA play a significant role in causing certain human diseases. Mitochondrial DNA mutations range from single base pair changes in the 16.5 kilobase pair genome up to large deletions and rearrangements. This report summarizes the current overall understanding of the mode and mechanism of mitochondrial DNA ...
S, Jeong-Yu, D A, Clayton
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The mitochondrial genome and psychiatric illness
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2012AbstractPsychiatric disorders are a leading cause of morbidity and mortality, yet their underlying pathophysiology remains unclear. Searches for a genetic cause of bipolar disorder, schizophrenia, and major depressive disorder have yielded inconclusive results. There is increasing interest in the possibility that defects in the mitochondrial genome may
Rebecca E S, Anglin +3 more
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TRANSCRIPTION OF THE MAMMALIAN MITOCHONDRIAL GENOME
Annual Review of Biochemistry, 1984PERSPECTIVES AND SUMMARY 573 GENOMIC ORGANIZATION 574 TRANSCRIPTIONAL MAPPING 576 INITIATION, ELONGATION, AND TERMINATION OF TRANSCRIPTION 578 I n Vivo Transcription 578 In Vitro Transcription 581 PROCESSING OF PRIMARY TRANSCRIPTS 582 POST-TRANSCRIPTIONAL MODIFICATION AND MATURATION OF RNA ..•..• ••...• 584 Ribosomal RN As 584 Transfer ...
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Genomics of Brain Aging: Nuclear and Mitochondrial Genomes☆
2009In recent times, the study of genomic changes associated with age has been improved by the introduction of microarray technology, which allows the detection of whole-genome expression profiles using single samples. Nuclear transcriptional modifications associated with the physiology and pathology of brain aging indicate the involvement of multiple ...
Prigione, A +2 more
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The mitochondrial genome in aging and senescence
Ageing Research Reviews, 2014Aging is characterized by a progressive decline in organism functions due to the impairment of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular system, as well as of largely post-mitotic organs, such as the heart and brain could be attributed at least in part to cell senescence.
A. Lauri, G. Pompilio, M. C. Capogrossi
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The organization and inheritance of the mitochondrial genome
Nature Reviews Genetics, 2005Mitochondrial DNA (mtDNA) encodes essential components of the cellular energy-producing apparatus, and lesions in mtDNA and mitochondrial dysfunction contribute to numerous human diseases. Understanding mtDNA organization and inheritance is therefore an important goal.
Xin Jie, Chen, Ronald A, Butow
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Mitochondrial genome diversity and the evolution of mitochondrial DNA
Canadian Journal of Biochemistry, 1982Mitochondrial DNA (mtDNA) is functionally conservative, encoding basically the same genes in all eukaryotes, yet mitochondrial genome organization and expression show an amazing diversity, and mtDNAs are highly variable in size and in potential information content.
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Structure and function of the mitochondrial genome
Journal of Inherited Metabolic Disease, 1992SummaryIt is now clear that molecular defects in human mitochondrial DNA play a significant role in human disease. Mitochondrial DNA mutations range from single base changes in the 16.5 kilobase‐pair genome up to large deletions and rearrangements. Independently of the actual cause of a given mutation, it is possible to predict at least some of the ...
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