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Evidence that the mitochondrial genome is the thrifty genome
Diabetes Research and Clinical Practice, 1999Although mitochondrial DNA (mtDNA) abnormalities are known to cause insulin deficiency, insulin resistance and diabetes mellitus, it's quantitative aspect was not addressed well. In this review, mitochondrial genome hypothesis of thrifty phenomenon is proposed, based on the data and review of literatures. From a population based epidemiologic study, it
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Mitochondrial genetics of Coprinus: Recombination of mitochondrial genomes
Current Genetics, 1983The formation of the sexual mycelium or dikaryon in the basidiomycete Coprinus cinereus involves exchange and migration of nuclei without accompanying exchange of mitochondria. The dikaryotic growth which appears around the periphery of mated monokaryons has exclusively the mitochondrial genome of the recipient cells.
J L, Baptista-Ferreira +2 more
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TRANSCRIPTION OF THE MAMMALIAN MITOCHONDRIAL GENOME
Annual Review of Biochemistry, 1984PERSPECTIVES AND SUMMARY 573 GENOMIC ORGANIZATION 574 TRANSCRIPTIONAL MAPPING 576 INITIATION, ELONGATION, AND TERMINATION OF TRANSCRIPTION 578 I n Vivo Transcription 578 In Vitro Transcription 581 PROCESSING OF PRIMARY TRANSCRIPTS 582 POST-TRANSCRIPTIONAL MODIFICATION AND MATURATION OF RNA ..•..• ••...• 584 Ribosomal RN As 584 Transfer ...
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Idiosyncrasies in decoding mitochondrial genomes
Biochimie, 2014Mitochondria originate from the α-proteobacterial domain of life. Since this unique event occurred, mitochondrial genomes of protozoans, fungi, plants and metazoans have highly derived and diverged away from the common ancestral DNA. These resulting genomes highly differ from one another, but all present-day mitochondrial DNAs have a very reduced ...
Jonathan L, Huot +8 more
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Genomics of Brain Aging: Nuclear and Mitochondrial Genomes☆
2009In recent times, the study of genomic changes associated with age has been improved by the introduction of microarray technology, which allows the detection of whole-genome expression profiles using single samples. Nuclear transcriptional modifications associated with the physiology and pathology of brain aging indicate the involvement of multiple ...
Prigione, A +2 more
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The mitochondrial genome in aging and senescence
Ageing Research Reviews, 2014Aging is characterized by a progressive decline in organism functions due to the impairment of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular system, as well as of largely post-mitotic organs, such as the heart and brain could be attributed at least in part to cell senescence.
Andrea, Lauri +2 more
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Mitochondrial genome diversity and the evolution of mitochondrial DNA
Canadian Journal of Biochemistry, 1982Mitochondrial DNA (mtDNA) is functionally conservative, encoding basically the same genes in all eukaryotes, yet mitochondrial genome organization and expression show an amazing diversity, and mtDNAs are highly variable in size and in potential information content.
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Inheritance of the Yeast Mitochondrial Genome
Plasmid, 1994Mitochondrion, extrachromosomal genetics, intergenic sequences, genome size, mitochondrial DNA, petite mutation ...
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Evolution of Mitochondrial Genomes in Fungi
1992Publisher Summary This chapter describes sizes, gene topology, and structures contributing to size variation of mitochondrial DNA (mtDNAs) in fungi. It also presents mechanisms for generating length mutations and rearrangements together with a description of mtDNA codon variations. Two unusual features of mtDNA from oomycetes and hypochytridiomycetes
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