Results 261 to 270 of about 457,413 (290)

Deletions of the mitochondrial genome [PDF]

open access: possibleJournal of Inherited Metabolic Disease, 1992
SummarySingle large deletions of mitochondrial DNA are found in the muscle of about 40% of patients with mitochondrial myopathies, and are detectable in both blood and muscle in Pearson syndrome. In mitochondrial myopathies, there is a close association between the presence of deletions and involvement of extra‐ocular muscles, together with other ...
S. R. Hammans, A. E. Harding
openaire   +2 more sources

Mitochondrial genome and longevity

Biochemistry (Moscow), 2016
The mitochondrial genome provides not only respiratory chain function, but it also ensures the impact of mitochondria on nearly all crucial metabolic processes. It is well known that mitochondria regulate aging and lifespan. However, until now there were no direct experimental data concerning the influence of various mitochondrial DNA variants on ...
Roman A. Zinovkin   +2 more
openaire   +3 more sources

The mitochondrial genome. The nucleoid [PDF]

open access: possibleBiochemistry (Moscow), 2016
Mitochondrial DNA (mtDNA) in cells is organized in nucleoids containing DNA and various proteins. This review discusses questions of organization and structural dynamics of nucleoids as well as their protein components. The structures of mt-nucleoid from different organisms are compared.
openaire   +2 more sources

The mitochondrial genome of yeast

Cell, 1978
mtDNA is the simplest DNA in nature which carries genes for the three classes of RNA-rRNAs, tRNAs, and mRNAs. In yeast, this genetic system has a number of unusual features that may even be of interest to molecular biologists who do not particularly care about mitochondrial biogenesis: -The gene for the large rRNA is split and the intervening sequence ...
Piet Borst, Leslie A. Grivell
openaire   +3 more sources

Platyzoan mitochondrial genomes

Molecular Phylogenetics and Evolution, 2013
Platyzoa is a putative lophotrochozoan (spiralian) subtaxon within the protostome clade of Metazoa, comprising a range of biologically diverse, mostly small worm-shaped animals. The monophyly of Platyzoa, the relationships between the putative subgroups Platyhelminthes, Gastrotricha and Gnathifera (the latter comprising at least Gnathostomulida ...
Holger Herlyn   +3 more
openaire   +3 more sources

The Mitochondrial Genome And Human Mitochondrial Diseases

Journal of the Peripheral Nervous System, 2002
To date, more than 100 point mutations and several hundreds of structural rearrangements of mitochondrial DNA (mtDNA) are known too be connected with characteristic neuromuscular and other mitochondrial syndromes varying from those causing death at the neonatal stage to diseases with late ages of onset. The immediate cause of mitochondrial disorders is
Rem I. Sukernik   +8 more
openaire   +3 more sources

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