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The influence of mitochondrial dynamics on mitochondrial genome stability
Current Genetics, 2017Mitochondria are dynamic organelles that fuse and divide. These changes alter the number and distribution of mitochondrial structures throughout the cell in response to developmental and metabolic cues. We have demonstrated that mitochondrial fission is essential to the maintenance of mitochondrial DNA (mtDNA) under changing metabolic conditions in ...
Christopher T, Prevost +6 more
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Evidence that the mitochondrial genome is the thrifty genome
Diabetes Research and Clinical Practice, 1999Although mitochondrial DNA (mtDNA) abnormalities are known to cause insulin deficiency, insulin resistance and diabetes mellitus, it's quantitative aspect was not addressed well. In this review, mitochondrial genome hypothesis of thrifty phenomenon is proposed, based on the data and review of literatures. From a population based epidemiologic study, it
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Mitochondrial Genomes of the Ciliates
1992Publisher Summary This chapter describes the mithochondrial genome of ciliates, with emphasis on Paramecium and Tetrahymena . Both Paramecium and Tetrahymena have linear genomes with unique replicative pathways. The mitochondrial genome of Paramecium aurelia is a linear duplex.
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Mitochondrial genetics of Coprinus: Recombination of mitochondrial genomes
Current Genetics, 1983The formation of the sexual mycelium or dikaryon in the basidiomycete Coprinus cinereus involves exchange and migration of nuclei without accompanying exchange of mitochondria. The dikaryotic growth which appears around the periphery of mated monokaryons has exclusively the mitochondrial genome of the recipient cells.
J L, Baptista-Ferreira +2 more
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TRANSCRIPTION OF THE MAMMALIAN MITOCHONDRIAL GENOME
Annual Review of Biochemistry, 1984PERSPECTIVES AND SUMMARY 573 GENOMIC ORGANIZATION 574 TRANSCRIPTIONAL MAPPING 576 INITIATION, ELONGATION, AND TERMINATION OF TRANSCRIPTION 578 I n Vivo Transcription 578 In Vitro Transcription 581 PROCESSING OF PRIMARY TRANSCRIPTS 582 POST-TRANSCRIPTIONAL MODIFICATION AND MATURATION OF RNA ..•..• ••...• 584 Ribosomal RN As 584 Transfer ...
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Genomics of Brain Aging: Nuclear and Mitochondrial Genomes☆
2009In recent times, the study of genomic changes associated with age has been improved by the introduction of microarray technology, which allows the detection of whole-genome expression profiles using single samples. Nuclear transcriptional modifications associated with the physiology and pathology of brain aging indicate the involvement of multiple ...
Prigione, A +2 more
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Regulation and function of the mitochondrial genome
Journal of Inherited Metabolic Disease, 1996SummaryMolecular changes in human mitochondrial DNA play a significant role in causing certain human diseases. Mitochondrial DNA mutations range from single base pair changes in the 16.5 kilobase pair genome up to large deletions and rearrangements. This report summarizes the current overall understanding of the mode and mechanism of mitochondrial DNA ...
S, Jeong-Yu, D A, Clayton
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The mitochondrial genome and psychiatric illness
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2012AbstractPsychiatric disorders are a leading cause of morbidity and mortality, yet their underlying pathophysiology remains unclear. Searches for a genetic cause of bipolar disorder, schizophrenia, and major depressive disorder have yielded inconclusive results. There is increasing interest in the possibility that defects in the mitochondrial genome may
Rebecca E S, Anglin +3 more
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Human evolution and the mitochondrial genome
Current Opinion in Genetics & Development, 1996The use of mitochondrial DNA (mtDNA) continues to dominate studies of human genetic variation and evolution. Recent work has re-affirmed the strict maternal inheritance of mtDNA, yielded new insights into the extent and nature of intra-individual variation, supported a recent African origin of human mtDNA, and amply demonstrated the utility of mtDNA in
M, Stoneking, H, Soodyall
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The mitochondrial genome in aging and senescence
Ageing Research Reviews, 2014Aging is characterized by a progressive decline in organism functions due to the impairment of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular system, as well as of largely post-mitotic organs, such as the heart and brain could be attributed at least in part to cell senescence.
Andrea, Lauri +2 more
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