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Mitochondrial fusion and inheritance of the mitochondrial genome
Journal of Plant Research, 2010Although maternal or uniparental inheritance of mitochondrial genomes is a general rule, biparental inheritance is sometimes observed in protists and fungi,including yeasts. In yeast, recombination occurs between the mitochondrial genomes inherited from both parents.Mitochondrial fusion observed in yeast zygotes is thought to set up a space for DNA ...
Kenta Onoue +2 more
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The mitochondrial genome and mitochondrial muscle disorders
Current Opinion in Pharmacology, 2001Mitochondrial disorders represent a multitude of clinically heterogeneous diseases in which the genetic abnormality can involve either a mitochondrial or nuclear gene. In addition to inherited defects, somatic mitochondrial DNA mutations have been implicated in the pathogenesis of neurodegenerative disease, cancer and the ageing process.
Andrew M. Schaefer +2 more
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Idiosyncrasies in decoding mitochondrial genomes
Biochimie, 2014Mitochondria originate from the α-proteobacterial domain of life. Since this unique event occurred, mitochondrial genomes of protozoans, fungi, plants and metazoans have highly derived and diverged away from the common ancestral DNA. These resulting genomes highly differ from one another, but all present-day mitochondrial DNAs have a very reduced ...
Huot, J +8 more
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Mitochondrial Genomes of the Ciliates
1992Publisher Summary This chapter describes the mithochondrial genome of ciliates, with emphasis on Paramecium and Tetrahymena . Both Paramecium and Tetrahymena have linear genomes with unique replicative pathways. The mitochondrial genome of Paramecium aurelia is a linear duplex.
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Evidence that the mitochondrial genome is the thrifty genome
Diabetes Research and Clinical Practice, 1999Although mitochondrial DNA (mtDNA) abnormalities are known to cause insulin deficiency, insulin resistance and diabetes mellitus, it's quantitative aspect was not addressed well. In this review, mitochondrial genome hypothesis of thrifty phenomenon is proposed, based on the data and review of literatures. From a population based epidemiologic study, it
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The mitochondrial genome in aging and senescence
Ageing Research Reviews, 2014Aging is characterized by a progressive decline in organism functions due to the impairment of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular system, as well as of largely post-mitotic organs, such as the heart and brain could be attributed at least in part to cell senescence.
A. Lauri, G. Pompilio, M. C. Capogrossi
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Comparison of mitochondrial genomes of bivalves
Hereditas (Beijing), 2009The structure and organization of mitochondrial genomes of 14 marine bivalves and two freshwater bivalves were analyzed using comparative genomics and bioinformatics methods. The results showed that the organization and gene order of the mitochondrial genomes of these bivalve species studied were different from each other.
Xianggang Gao +5 more
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The Mitochondrial Genome in Embryo Technologies
Reproduction in Domestic Animals, 2003ContentsThe mammalian mitochondrial genome encodes for 37 genes which are involved in a broad range of cellular functions. The mitochondrial DNA (mtDNA) molecule is commonly assumed to be inherited through oocyte cytoplasm in a clonal manner, and apparently species‐specific mechanisms have evolved to eliminate the contribution of sperm mitochondria ...
Hiendleder, S., Wolf, E.
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TRANSCRIPTION OF THE MAMMALIAN MITOCHONDRIAL GENOME
Annual Review of Biochemistry, 1984PERSPECTIVES AND SUMMARY 573 GENOMIC ORGANIZATION 574 TRANSCRIPTIONAL MAPPING 576 INITIATION, ELONGATION, AND TERMINATION OF TRANSCRIPTION 578 I n Vivo Transcription 578 In Vitro Transcription 581 PROCESSING OF PRIMARY TRANSCRIPTS 582 POST-TRANSCRIPTIONAL MODIFICATION AND MATURATION OF RNA ..•..• ••...• 584 Ribosomal RN As 584 Transfer ...
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The influence of mitochondrial dynamics on mitochondrial genome stability
Current Genetics, 2017Mitochondria are dynamic organelles that fuse and divide. These changes alter the number and distribution of mitochondrial structures throughout the cell in response to developmental and metabolic cues. We have demonstrated that mitochondrial fission is essential to the maintenance of mitochondrial DNA (mtDNA) under changing metabolic conditions in ...
Christina Seger +7 more
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