Results 111 to 120 of about 1,842,476 (313)

ATRX restricts Human Cytomegalovirus (HCMV) viral DNA replication through heterochromatinization and minimizes unpackaged viral genomes.

PLoS Pathogens
ATRX limits the accumulation of human cytomegalovirus (HCMV) Immediate Early (IE) proteins at the start of productive, lytic infections, and thus is a part of the cell-intrinsic defenses against infecting viruses.
Ryan M Walter, Kinjal Majumder, Robert F Kalejta   +2 more
doaj   +1 more source

The Chromatin Landscape of Kaposi’s Sarcoma-Associated Herpesvirus

Viruses, 2013
Kaposi’s sarcoma-associated herpesvirus is an oncogenic γ-herpesvirus that causes latent infection in humans. In cells, the viral genome adopts a highly organized chromatin structure, which is controlled by a wide variety of cellular and viral chromatin ...
Zsolt Toth, Kevin Brulois, Jae U. Jung
doaj   +1 more source

Common Genetic Variation and the Control of HIV-1 in Humans [PDF]

, 2009
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects.
Cirulli, Elizabeth T, Gunthard, HF, Thomas J. Urban, Andrew J. Mcmichael, Guenthard, Huldrych F., Gumbs, CE, Feng, S, Feng, Sheng, De Luca Andrea, McMichael, A. J, Obel, N., Miró Meda, José M. (José María), 1956-, O'Brien SJ, Haynes BF, Haynes, B. F, Ge, D., Letvin, Norman L., Jeremy J. Martinson, Martinson, J. J, Beckmann, J S, Smith, Jason P., Descombes P, Cozzi-Lepri, A, Jacobson, L P, Margolick, J B, Cirulli, E. T, Shianna, K V, Niels Obel, Ge Dongliang, Simon Mallal, Wolinsky, Steven M, Jacques S Beckmann, Urban TJ, O'Brien, S J, Antonarakis, S.E., Wolinsky, S. M, Bruno Ledergerber, Telenti, A., Urban, T.J., Ge, DL, Detels, R, Javier Martinez-Picado, Günthard, H F, Letvin, NL, Jason P. Smith, Zhang, Kunlin, Cirulli Elizabeth T., Colombo S, Colombo, S, McMichael, AJ, Feng S, McMichael, Andrew J., Joseph B. Margolick, Mussini, C., Cozzi-Lepri Alessandro, Sheng Feng, Descombes Patrick, Letvin NL, Goldstein, DB, Barton F. Haynes, Fellay, J., Jacobson, Lisa, Goldstein, D. B., Feng, S., Martínez Picado, Francisco Javier, Antonella Castagna, Haynes, BF, Telenti, A, Jacobson, L.P., Shianna, K.V., Fellay Jacques, Miro, José M, Antonarakis Stylianos E., Mcmichael, Andrew, David B Goldstein, Gumbs, C. E, Jacobson, Lisa P., Miro, José M., Jason P Smith, Miro, J.M., Cirulli, Elizabeth T., Antonarakis SE, Shianna, Kevin V, Easterbrook, P, Martinson, Jeremy J, Stylianos E Antonarakis, Gumbs, Curtis E, O'Brien, Stephen J, Mary Carrington, Mallal, S, Zhang, K, Curtis E. Gumbs, Castagna, A., Martinson, J J, Detels, Roger, Wolinsky SM, Easterbrook, Philippa, Haynes, Barton F, Letvin, N L, Letvin, N. L, Colombo, Sara, Martinez Picado J, Gumbs CE, Cozzi Lepri A, Haynes, B F, Smith, J P, Letvin, Norman L, Jacques Fellay, Ledergerber B, Telenti, Amalio, Carrington M, Dalmau, J., Mallal, Simon, De Luca, Andrea, Easterbrook Philippa, Martinez-Picado Javier, Wolinsky, Steven, Dalmau J, Beckmann, Jacques, Jacobson, L. P, O'Brien, S. J, Margolick, Joseph B, NIAID Center for HIV/AIDS Vaccine Immunology, Amalio Telenti* David B. Goldstein, Miro, J. M, Dongliang Ge, Margolick JB, Shianna, K. V, Cozzi-Lepri, Alessandro, Smith, J. P., Elizabeth T Cirulli, Amalio Telenti, Jacobson Lisa P., Carrington Mary, Goldstein, David B, Huldrych F. Günthard, Gumbs Curtis E., De, Luca A., Feng Sheng, Urban, TJ, Carrington, M, Antonarakis, Stylianos E, Kevin V Shianna, Ledergerber, B., Martinson Jeremy J., Martinson, Jeremy J., Goldstein, David B., Urban, T J, Urban Thomas J., Günthard, H. F, Margolick Joseph B., Cristina Mussini, Elizabeth T, Ge, Dongliang, Urban, Thomas J., Stylianos E. Antonarakis, Günthard, H.F., McMichael AJ, Wolinsky Steven M., Telenti Amalio, Martinez-Picado, J, Miro, J M, Cirulli ET, Huldrych F Günthard, Urban, Thomas J, Stephen J O'Brien, Martinez-Picado, Javier, Steven M. Wolinsky, Zhang K, Easterbrook P, Cirulli, Elisabeth T., Curtis E Gumbs, José M Miro, Shianna Kevin V., Jacobson, Lisa P, Wolinsky, S M, Lisa P. Jacobson, Günthard HF, Martinson, J.J., Norman L Letvin, Mallal Simon, Ledergerber, B, McMichael, A.J., McMichael, Andrew J, Smith, J.P., Gumbs, Curtis E., Günthard, Huldrych F., Smith, JP, Fellay, Jacques, Beckmann, Jacques S., Antonarakis, SE, Miro JM, Ledergerber, Bruno, Telenti A, Lisa P Jacobson, Wolinsky, Steven M., Roger Detels, Antonarakis, S E, Urban, T. J, Mallal, S., Günthard, Huldrych F, Obel, N, Cirulli, E T, Martinson JJ, Patrick Descombes, Ledergerber Bruno, Haynes Barton F., Mussini, C, Philippa Easterbrook, Descombes, P, Fellay J, Goldstein David B., Fellay, J, Margolick, Joseph B., Goldstein, D B, Steven M Wolinsky, Zhang Kunlin, Castagna A, Smith, Jason P, Descombes, Patrick, Gumbs, C E, Letvin Norman L., Goldstein, D.B., Margolick, JB, Smith JP, Smith, J. P, Beckmann, J. S, Wolinsky, S.M., Beckmann, Jacques S, Andrew J McMichael, Andrea De Luca, Beckmann, J.S., Jeremy J Martinson, Beckmann JS, NIAID Ctr HIV AIDS Vaccine Immunol, Shianna, KV, Haynes, Barton F., Gumbs, C.E., Jacques S. Beckmann, Ge D, McCarthy, M.I., Ge, D, McMichael Andrew J., Cirulli, ET, O'Brien, Stephen J., Norman L. Letvin, O\u27Brien, Stephen J., Dalmau Judith, Cozzi-Lepri, A., Haynes, B.F., Detels R, Ro Cozzi-lepri, Smith Jason P., Margolick, J.B., Günthard Huldrych F., Gumbs, Curtis, Zhang, KL, Colombo, S., Margolick, Joseph, De Luca A, Margolick, J. B, Beckmann Jacques S., O'Brien, Stephen, Shianna, Kevin V., Barton F Haynes, Dalmau, J, Kevin V. Shianna, Jacobson, LP, Wolinsky, SM, Martinez-Picado, J., Antonarakis, S. E, Mallal S, Carrington, Mary, Colombo Sara, Zhang, K., Letvin, N.L., Castagna, A, Obel, Niels, Mussini, Cristina, Detels Roger, O'Brien, S.J., Carrington, M., Obel Niels, Cirulli, E.T., Antonarakis, Stylianos E., Goldstein DB, Thomas J Urban, Descombes, P., Castagna, Antonella, Jose ́ M. Miro, Miro, JM, Sara Colombo, Judith Dalmau, O'Brien Stephen J., De Luca, A., Kunlin Zhang, Castagna Antonella, De Luca, A, Beckmann, JS, Stephen J. O’brien, Mussini Cristina, Easterbrook, P., Jacobson LP, Miro José M., Martinson, JJ, NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI), Obel N, O'Brien, SJ, Shianna KV, Dalmau, Judith, McMichael, A J, Letvin, Norman Lee, Joseph B Margolick, Detels, R., Alessandro Cozzi-Lepri, CASTAGNA , ANTONELLA, Guenthard Huldrych F., Miró Meda, José M., Cozzi Lepri Alessandro, Martinez Picado Javier   +319 more
core   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Regulatory elements in the viral genome

Virology, 2013
The small DNA genomes of papillomaviruses contain a surprisingly large number of regulatory or cis-responsive elements, which regulate replication and transcription of the virus, and control details like specificity for certain epithelial cells, specificity for layers in squamous epithelia, feedback mechanisms and coupling between host cell physiology ...
openaire   +2 more sources

Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel [PDF]

Nat Commun, 2020
Miller D, Martin MA, Harel N, Kustin T, Tirosh O, Meir M, Sorek N, Gefen-Halevi S, Amit S, Vorontsov O, Wolf D, Peretz A, Shemer-Avni Y, Roif-Kaminsky D, Kopelman N, Huppert A, Koelle K, Stern A.   +17 more
europepmc   +2 more sources

Influence of genome-scale RNA structure disruption on the replication of murine norovirus--similar replication kinetics in cell culture but attenuation of viral fitness in vivo [PDF]

, 2013
Mechanisms by which certain RNA viruses, such as hepatitis C virus, establish persistent infections and cause chronic disease are of fundamental importance in viral pathogenesis.
Evans, David J, Simmonds, Peter, Bailey, Dalan, McFadden, Nora, Arias, Armando, Evans, David J., Witteveldt, Jeroen, Dry, Inga, Goodfellow, Ian   +8 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions [PDF]

, 2012
Herpes viruses are prevalent and well characterized human pathogens. Despite extensive study, much remains to be learned about the structure of the genome packaging and release machinery in the capsids of these large and complex double-stranded DNA ...
Rixon Frazer J., Schmid Michael F., Rixon, Frazer J., Bhella David, David Bhella, Ryan H. Rochat (129683), Hecksel, Corey W., Rochat, Ryan H., Hecksel Corey W., Chiu Wah, Bhella, David, Chiu, Wah, Wah Chiu, Michael F. Schmid (129681), Michael F Schmid, Rochat Ryan H., Corey W Hecksel, Schmid, Michael F., David Bhella (129684), Frazer J. Rixon (129686), Frazer J Rixon, Corey W. Hecksel (129682), Ryan H Rochat, Wah Chiu (129685)   +23 more
core   +1 more source