Results 131 to 140 of about 2,630,320 (343)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Virus hepatitisa G - novi hepatotropni virus [PDF]

Vojnosanitetski Pregled, 2002
Kuljić-Kapulica Nada
doaj   +1 more source

Triple lysine and nucleosome-binding motifs of the viral IE19 protein are required for human cytomegalovirus S-phase infections

mBio
Herpesvirus genomes are maintained as extrachromosomal plasmids within the nuclei of infected cells. Some herpesviruses persist within dividing cells, putting the viral genome at risk of being lost to the cytoplasm during mitosis because karyokinesis ...
Minor R. Maliano, Kristen D. Yetming, Robert F. Kalejta   +2 more
doaj   +1 more source

Is Banana streak virus/Arabidopsis thaliana a viable pathosystem? [P.33] [PDF]

, 2015
Banana streak viruses (BSV) infect bananas and plantains (Musa spp.) worldwide. BSV became a major constraint for banana breeding programmes and germplasm exchanges since the discovery a couple of decade ago of the presence of infectious BSV integrations
Caruana, Marie-Line, Chabannes, Matthieu, Laboureau, Nathalie   +2 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression [PDF]

, 2015
Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has been reported in B-cells during the viral lytic ...
Alison J. Sinclair, Anja Godfrey, Bailey, Bark-Jones, Beatty, Ben-Bassat, Bergbauer, Bhende, Bhende, Broderick, Carey, Chang, Chi, Farnham, Feederle, Feng, Flemington, Flower, Gentleman, Gordon Peters, Grabherr, Gupta, Gustems, Halder, Harshil Patel, Heather, Hollyoake, Hsu, Huang da, Huang da, Ijiel B. Naranjo Perez-Fernandez, Inman, Israel, Jiang, Jianmin Zuo, Kalla, Kalla, Kay Osborn, Kenney, Kenney, Klug, Krig, Kuppers, Li, Lieberman, Lieberman, Lieberman, Longnecker, Ma, Machanick, Martin Rowe, McClellan, Miller, Molyneux, Nicolae Balan, Pruitt, Rajaei Al-Mohammad, Ramasubramanyan, Ramasubramanyan, Richard G. Jenner, Rickinson, Rowe, Rowe, Scacheri, Shannon-Lowe, Sharada Ramasubramanyan, Takada, Thorvaldsdottir, Tsai, Tsang, Vetsika, Whyte, Yang, Young, Young, Yuan, Zuo, Zuo   +77 more
core   +1 more source

Viral Evolution in the Genomic Age

PLoS Biology, 2007
The remarkable increase in the number of viral genome sequences represents both opportunities and challenges for understanding disease ecology and evolution, and must stimulate researchers to address questions that were previously considered out of reach.
openaire   +4 more sources

Real-time, portable genome sequencing for Ebola surveillance

Nature, 2016
The Ebola virus disease epidemic in West Africa is the largest on record, responsible for over 28,599 cases and more than 11,299 deaths. Genome sequencing in viral outbreaks is desirable to characterize the infectious agent and determine its evolutionary
J. Quick, N. Loman, S. Duraffour, J. Simpson, E. Severi, L. Cowley, J. A. Boré, Raymond Koundouno, G. Dudas, A. Mikhail, N. Ouédraogo, B. Afrough, A. Bah, J. H. Baum, B. Becker-Ziaja, J. Boettcher, Mar Cabeza-Cabrerizo, Alvaro Camino-Sanchez, Lisa L. Carter, J. Doerrbecker, T. Enkirch, Isabel Graciela García Dorival, Nicole Hetzelt, J. Hinzmann, Tobias Holm, L. Kafetzopoulou, Michel Koropogui, Abigail Kosgey, Eeva Kuisma, C. Logue, A. Mazzarelli, S. Meisel, M. Mertens, J. Michel, D. Ngabo, K. Nitzsche, Elisa Pallash, L. Patrono, Jasmine Portmann, J. Repits, Natasha Y. Rickett, A. Sachse, Katrin Singethan, I. Vitoriano, Rahel L Yemanaberhan, E. Zekeng, Racine Trina, A. Bello, A. Sall, O. Faye, O. Faye, N. Magassouba, C. V. Williams, Victoria Amburgey, L. Winona, E. Davis, J. Gerlach, F. Washington, V. Monteil, M. Jourdain, M. Bererd, Alimou Camara, H. Somlaré, A. Camara, Marianne Gérard, G. Bado, Bernard Baillet, D. Delaune, K. Nebie, A. Diarra, Yacouba Savane, R. Pallawo, G. Gutierrez, N. Milhano, Isabelle Roger, Christopher Williams, Facinet Yattara, Kuiama Lewandowski, Jamie Taylor, P. Rachwal, D. Turner, G. Pollakis, J. Hiscox, D. Matthews, M. O’Shea, A. Johnston, Duncan R. Wilson, E. Hutley, E. Smit, A. di Caro, R. Woelfel, K. Stoecker, E. Fleischmann, Martin Gabriel, S. Weller, L. Koivogui, B. Diallo, S. Keita, A. Rambaut, P. Formenty, S. Gunther, M. Carroll   +101 more
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source