Results 91 to 100 of about 3,155,630 (345)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Association between human blood metabolome and the risk of delirium: a Mendelian Randomization study

Frontiers in Endocrinology
BackgroundDelirium significantly contributes to both mortality and morbidity among hospitalized older adults. Furthermore, delirium leads to escalated healthcare expenditures, extended hospital stays, and enduring cognitive deterioration, all of which ...
Chubing Long, Chubing Long, Dong Lin, Dong Lin, Lieliang Zhang, Lieliang Zhang, Yue Lin, Yue Lin, Qing Yao, Qing Yao, Guangyong Zhang, Guangyong Zhang, Longshan Li, Longshan Li, Hailin Liu, Hailin Liu, Jun Ying, Jun Ying, Xifeng Wang, Xifeng Wang, Fuzhou Hua, Fuzhou Hua   +21 more
doaj   +1 more source

Genome-Wide Association Study of Bronchodilator Drug Response (BDR) in Minority Children with Asthma Provides Insights into Its Genetic Risk Factors [PDF]

, 2021
Jin Hui Joo, Angel C. Y. Mak, Shujie Xiao, Patrick Sleiman, Diane Hu, Scott Huntsman, Celeste Eng, Mengyuan Kan, Avantika R. Diwadkar, Håkon Håkonarson, L. Keoki Williams, EG Burchard, Blanca E. Himes   +12 more
openalex   +1 more source

A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. [PDF]

, 2016
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone ...
Bian, Zhaolian, Chen, Haoyan, Gershwin, M Eric, Jiang, Xiang, Li, Enling, Li, Zhiqiang, Lian, Min, Liao, Wilson, Ma, Xiong, Miao, Qi, Seldin, Michael F, Shi, Yongyong, Tang, Ruqi, Wang, Qixia, Wang, Zhaoyue, Wei, Yiran, Yang, Fan, Yang, Yue, Zhang, Haiyan   +18 more
core   +2 more sources

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

Nature Genetics, 2009
To identify genetic factors influencing quantitative traits of biomedical importance, we conducted a genome-wide association study in 8,842 samples from population-based cohorts recruited in Korea.
Y. Cho, M. Go, Y. J. Kim, J. Heo, J. Oh, H. Ban, Dankyu Yoon, Mi Hee Lee, Dong-Joon Kim, Miey Park, S. Cha, Jun-Woo Kim, B. Han, H. Min, Y. Ahn, Man Suk Park, H. Han, H. Jang, E. Cho, Jong-Eun Lee, N. Cho, C. Shin, T. Park, Ji Wan Park, Jong-Keuk Lee, L. Cardon, G. Clarke, M. McCarthy, Jong-Young Lee, Jong-Koo Lee, B. Oh, Hyung-Lae Kim   +31 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research

Frontiers in Medicine
Myasthenia gravis (MG) is an autoimmune disorder involving complex interactions between genetic and environmental factors. Genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and other methods have identified multiple ...
Zheng Yixian, Wang Hai, Liu Xiuying, Yan Jichun   +3 more
doaj   +1 more source

Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study.

JAMA Neurology, 2020
Importance Large-scale genome-wide association studies in the European population have identified 90 risk variants associated with Parkinson disease (PD); however, there are limited studies in the largest population worldwide (ie, Asian). Objectives To
J. Foo, E. Chew, S. Chung, R. Peng, C. Blauwendraat, M. Nalls, K. Mok, W. Satake, T. Toda, Y. Chao, L. Tan, M. Tandiono, M. Lian, E. Ng, K. Prakash, W. Au, W. Meah, S. Mok, A. A. Annuar, Anne Y. Y. Chan, Ling Chen, Yongping Chen, B. Jeon, Lulu Jiang, Jia Lun Lim, Juei-Jueng Lin, Chunfeng Liu, C. Mao, V. Mok, Z. Pei, H. Shang, Changhe Shi, K. Song, A. Tan, Yih-Ru Wu, Yu-ming Xu, Renshi Xu, Yaping Yan, Jing Yang, Baorong Zhang, W. Koh, Shen-Yang Lim, C. Khor, Jianjun Liu, E. Tan   +44 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

bioRxiv, 2019
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype 1 – 3 . To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 ...
Haoyu Zhang, T. Ahearn, J. Lecarpentier, D. Barnes, J. Beesley, Xia Jiang, T. O’Mara, Guanghao Qi, Ni Zhao, M. Bolla, A. Dunning, J. Dennis, Qin Wang, Z. Ful, K. Aittomäki, I. Andrulis, H. Anton-Culver, V. Arndt, K. Aronson, B. Arun, P. Auer, J. Azzollini, D. Barrowdale, H. Becher, M. Beckmann, S. Behrens, J. Benítez, M. Bermisheva, K. Białkowska, A. Blanco, C. Blomqvist, N. Bogdanova, S. Bojesen, B. Bonanni, Davide Bondavalli, Å. Borg, H. Brauch, H. Brenner, I. Briceño, A. Broeks, S. Brucker, T. Brüning, B. Burwinkel, S. Buys, H. Byers, T. Caldés, M. Caligo, M. Calvello, D. Campa, J. Castelao, J. Chang-Claude, S. Chanock, M. Christiaens, H. Christiansen, W. Chung, K. Claes, C. Clarke, S. Cornelissen, F. Couch, A. Cox, S. Cross, K. Czene, M. Daly, P. Devilee, O. Díez, S. Domchek, T. Dörk, M. Dwek, D. Eccles, A. Ekici, D. Evans, P. Fasching, J. Figueroa, L. Foretova, F. Fostira, E. Friedman, D. Frost, M. Gago-Domínguez, S. Gapstur, J. Garber, J. García-Saenz, M. Gaudet, S. Gayther, G. Giles, A. Godwin, M. Goldberg, D. Goldgar, A. González-Neira, M. Greene, J. Gronwald, P. Guénel, L. Häberle, E. Hahnen, C. Haiman, Christopher R. Hake, P. Hall, U. Hamann, E. Harkness, Bernadette A. M. Heemskerk-Gerritsen, P. Hillemanns, F. Hogervorst, B. Holleczek, A. Hollestelle, M. Hooning, R. Hoover, J. Hopper, A. Howell, H. Huebner, P. Hulick, E. Imyanitov, C. Isaacs, L. Izatt, A. Jager, M. Jakimovska, A. Jakubowska, P. James, R. Janavicius, W. Janni, E. John, Michael E. Jones, A. Jung, R. Kaaks, P. Kapoor, B. Karlan, R. Keeman, Sofia Khan, E. Khusnutdinova, C. Kitahara, Y. Ko, I. Konstantopoulou, L. Koppert, S. Koutros, V. Kristensen, A. Laenkholm, D. Lambrechts, S. Larsson, P. Laurent-Puig, C. Lázaro, E. Lazarova, F. Lejbkowicz, Goska Leslie, F. Lesueur, A. Lindblom, J. Lissowska, W. Lo, J. Loud, J. Lubiński, A. Lukomska, R. MacInnis, A. Mannermaa, M. Manoochehri, S. Manoukian, S. Margolin, M. Martínez, L. Matricardi, L. McGuffog, C. Mclean, Noura Mebirouk, A. Meindl, U. Menon, Austin Miller, E. Mingazheva, M. Montagna, A. Mulligan, C. Mulot, T. Muranen, K. Nathanson, S. Neuhausen, H. Nevanlinna, P. Neven, W. Newman, F. Nielsen, L. Nikitina-Zake, J. Nodora, K. Offit, E. Oláh, O. Olopade, H. Olsson, N. Orr, L. Papi, J. Papp, T. Park-Simon, M. Parsons, B. Peissel, Ana Peixoto, B. Peshkin, P. Peterlongo, J. Peto, K. Phillips, M. Piedmonte, D. Plaseska‐Karanfilska, Karolina Prajzendanc, R. Prentice, Darya Prokofyeva, B. Rack, P. Radice, S. Ramus, Johanna Rantala, M. Rashid, G. Rennert, H. Rennert, H. Risch, A. Romero, M. Rookus, M. Rübner, T. Rüdiger, E. Saloustros, S. Sampson, D. Sandler, E. Sawyer, M. Scheuner, R. Schmutzler, A. Schneeweiss, M. Schoemaker, B. Schöttker, P. Schürmann, L. Senter, Priyanka Sharma, M. Sherman, X. Shu, C. Singer, S. Smichkoska, P. Soucy, M. Southey, J. Spinelli, J. Stone, D. Stoppa-Lyonnet, A. Swerdlow, C. Szabo, R. Tamimi, W. Tapper, Jack A. Taylor, M. Teixeira, M. Terry, M. Thomassen, D. Thull, M. Tischkowitz, A. Toland, R. Tollenaar, I. Tomlinson, Diana Torres, M. Troester, Thérèse Truong, N. Tung, M. Untch, C. Vachon, A. V. D. van den Ouweland, L. E. van der Kolk, Elke M. van Veen, E. J. van Rensburg, A. Vega, B. Wappenschmidt, C. Weinberg, J. Weitzel, H. Wildiers, R. Winqvist, A. Wolk, Xiaohong R. Yang, D. Yannoukakos, W. Zheng, K. Zorn, M. Zuradelli, R. Milne, P. Kraft, J. Simard, P. Pharoah, K. Michailidou, A. Antoniou, M. Schmidt, G. Chenevix-Trench, D. Easton, M. García-Closas, N. Chatterjee   +272 more
semanticscholar   +1 more source