Results 91 to 100 of about 3,091,688 (344)
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. [PDF]
, 2011 BackgroundRheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA).Alfredsson, Lars, Ding, Bo, Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study group, Klareskog, Lars, Ong, Rick TH, Padyukov, Leonid, Rönnelid, Johan, Seddighzadeh, Maria, Seielstad, Mark +8 morecore A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain [PDF]
, 2014 BACKGROUND: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients., , Colhoun, H. M., Deshmukh, H. A., Donnelly, L. A., Liu, Y., Meng, W., Morris, A. D., Palmer, C. N. A., Smith, B. H., van Zuydam, N. R., Zhou, K. +11 morecore +4 more sourcesGenome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
bioRxiv, 2019 Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype 1 – 3 . To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 ...Haoyu Zhang, T. Ahearn, J. Lecarpentier, D. Barnes, J. Beesley, Xia Jiang, T. O’Mara, Guanghao Qi, Ni Zhao, M. Bolla, A. Dunning, J. Dennis, Qin Wang, Z. Ful, K. Aittomäki, I. Andrulis, H. Anton-Culver, V. Arndt, K. Aronson, B. Arun, P. Auer, J. Azzollini, D. Barrowdale, H. Becher, M. Beckmann, S. Behrens, J. Benítez, M. Bermisheva, K. Białkowska, A. Blanco, C. Blomqvist, N. Bogdanova, S. Bojesen, B. Bonanni, Davide Bondavalli, Å. Borg, H. Brauch, H. Brenner, I. Briceño, A. Broeks, S. Brucker, T. Brüning, B. Burwinkel, S. Buys, H. Byers, T. Caldés, M. Caligo, M. Calvello, D. Campa, J. Castelao, J. Chang-Claude, S. Chanock, M. Christiaens, H. Christiansen, W. Chung, K. Claes, C. Clarke, S. Cornelissen, F. Couch, A. Cox, S. Cross, K. Czene, M. Daly, P. Devilee, O. Díez, S. Domchek, T. Dörk, M. Dwek, D. Eccles, A. Ekici, D. Evans, P. Fasching, J. Figueroa, L. Foretova, F. Fostira, E. Friedman, D. Frost, M. Gago-Domínguez, S. Gapstur, J. Garber, J. García-Saenz, M. Gaudet, S. Gayther, G. Giles, A. Godwin, M. Goldberg, D. Goldgar, A. González-Neira, M. Greene, J. Gronwald, P. Guénel, L. Häberle, E. Hahnen, C. Haiman, Christopher R. Hake, P. Hall, U. Hamann, E. Harkness, Bernadette A. M. Heemskerk-Gerritsen, P. Hillemanns, F. Hogervorst, B. Holleczek, A. Hollestelle, M. Hooning, R. Hoover, J. Hopper, A. Howell, H. Huebner, P. Hulick, E. Imyanitov, C. Isaacs, L. Izatt, A. Jager, M. Jakimovska, A. Jakubowska, P. James, R. Janavicius, W. Janni, E. John, Michael E. Jones, A. Jung, R. Kaaks, P. Kapoor, B. Karlan, R. Keeman, Sofia Khan, E. Khusnutdinova, C. Kitahara, Y. Ko, I. Konstantopoulou, L. Koppert, Stella Koutros, V. Kristensen, A. Laenkholm, D. Lambrechts, S. Larsson, P. Laurent-Puig, C. Lázaro, E. Lazarova, F. Lejbkowicz, Goska Leslie, F. Lesueur, A. Lindblom, J. Lissowska, W. Lo, J. Loud, J. Lubiński, A. Lukomska, R. MacInnis, A. Mannermaa, M. Manoochehri, S. Manoukian, S. Margolin, M. Martínez, L. Matricardi, L. McGuffog, C. Mclean, Noura Mebirouk, A. Meindl, U. Menon, Austin Miller, E. Mingazheva, M. Montagna, A. Mulligan, C. Mulot, T. Muranen, K. Nathanson, S. Neuhausen, H. Nevanlinna, P. Neven, W. Newman, F. Nielsen, L. Nikitina-Zake, J. Nodora, K. Offit, E. Oláh, O. Olopade, H. Olsson, N. Orr, L. Papi, J. Papp, T. Park-Simon, M. Parsons, B. Peissel, Ana Peixoto, B. Peshkin, P. Peterlongo, J. Peto, K. Phillips, M. Piedmonte, D. Plaseska‐Karanfilska, Karolina Prajzendanc, R. Prentice, Darya Prokofyeva, B. Rack, P. Radice, S. Ramus, Johanna Rantala, M. Rashid, G. Rennert, H. Rennert, H. Risch, A. Romero, M. Rookus, M. Rübner, T. Rüdiger, E. Saloustros, S. Sampson, D. Sandler, E. Sawyer, M. Scheuner, R. Schmutzler, A. Schneeweiss, M. Schoemaker, B. Schöttker, P. Schürmann, L. Senter, Priyanka Sharma, M. Sherman, X. Shu, C. Singer, S. Smichkoska, P. Soucy, M. Southey, J. Spinelli, J. Stone, D. Stoppa-Lyonnet, A. Swerdlow, C. Szabo, R. Tamimi, W. Tapper, Jack A. Taylor, M. Teixeira, M. Terry, M. Thomassen, D. Thull, M. Tischkowitz, A. Toland, R. Tollenaar, I. Tomlinson, Diana Torres, M. Troester, Thérèse Truong, N. Tung, M. Untch, C. Vachon, A. V. D. van den Ouweland, L. E. van der Kolk, Elke M. van Veen, E. J. van Rensburg, A. Vega, B. Wappenschmidt, C. Weinberg, J. Weitzel, H. Wildiers, R. Winqvist, A. Wolk, Xiaohong R. Yang, D. Yannoukakos, W. Zheng, K. Zorn, M. Zuradelli, R. Milne, P. Kraft, J. Simard, P. Pharoah, K. Michailidou, A. Antoniou, M. Schmidt, G. Chenevix-Trench, D. Easton, M. García-Closas, N. Chatterjee +272 moresemanticscholar +1 more sourceBy dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey +2 morewiley +1 more sourceEnhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs
Advanced ScienceMany cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)‐mediated genetic effects from 28 033 RNA sequencing samples across 11 ...Wenyan Chen, Zeyang Wang, Yinuo Wang, Jianxiang Lin, Shuxin Chen, Hui Chen, Xuelian Ma, Xudong Zou, Xing Li, Yangmei Qin, Kewei Xiong, Xixian Ma, Qi Liao, Yunbo Qiao, Lei Li +14 moredoaj +1 more sourceAn Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Diabetes, 2017 To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using ...R. Scott, L. Scott, R. Mägi, L. Marullo, K. Gaulton, M. Kaakinen, N. Pervjakova, T. Pers, Andrew D. Johnson, J. Eicher, A. Jackson, T. Ferreira, Yeji Lee, Clement Ma, V. Steinthorsdottir, G. Thorleifsson, L. Qi, Natalie R. van Zuydam, A. Mahajan, Han Chen, P. Almgren, B. Voight, H. Grallert, M. Müller-Nurasyid, J. Ried, N. W. Rayner, N. Robertson, L. Karssen, E. V. van Leeuwen, Sara M. Willems, C. Fuchsberger, P. Kwan, Tanya M. Teslovich, Pritam Chanda, Man Li, Yingchang Lu, C. Dina, Dorothée Thuillier, L. Yengo, Longda Jiang, T. Sparsø, H. Kestler, H. Chheda, L. Eisele, S. Gustafsson, Mattias Frånberg, R. Strawbridge, R. Benediktsson, Á. Hreidarsson, A. Kong, G. Sigurðsson, N. Kerrison, J. Luan, L. Liang, T. Meitinger, M. Roden, B. Thorand, T. Esko, E. Mihailov, C. Fox, Ching‐Ti Liu, Denis Rybin, B. Isomaa, V. Lyssenko, T. Tuomi, D. Couper, J. Pankow, N. Grarup, C. Have, M. Jørgensen, T. Jørgensen, A. Linneberg, M. Cornelis, R. V. van Dam, D. Hunter, P. Kraft, Qi Sun, S. Edkins, K. Owen, J. Perry, A. Wood, E. Zeggini, Juan Tajes-Fernandes, G. Abecasis, L. Bonnycastle, P. Chines, H. Stringham, H. Koistinen, L. Kinnunen, B. Sennblad, Thomas W. Mühleisen, M. Nöthen, S. Pechlivanis, D. Baldassarre, K. Gertow, S. Humphries, E. Tremoli, N. Klopp, Julia Meyer, G. Steinbach, R. Wennauer, J. Eriksson, S. Mӓnnistö, L. Peltonen, E. Tikkanen, G. Charpentier, Elodie Eury, S. Lobbens, B. Gigante, K. Leander, O. Mcleod, E. Bottinger, O. Gottesman, D. Ruderfer, M. Blüher, P. Kovacs, Anke Tonjes, N. Maruthur, C. Scapoli, R. Erbel, K. Jöckel, S. Moebus, U. de Faire, A. Hamsten, M. Stumvoll, P. Deloukas, P. Donnelly, T. Frayling, A. Hattersley, S. Ripatti, V. Salomaa, N. Pedersen, B. Boehm, R. Bergman, F. Collins, K. Mohlke, J. Tuomilehto, T. Hansen, O. Pedersen, I. Barroso, L. Lannfelt, E. Ingelsson, L. Lind, C. Lindgren, S. Cauchi, P. Froguel, R. Loos, B. Balkau, H. Boeing, P. Franks, A. Barricarte Gurrea, D. Palli, Y. T. van der Schouw, D. Altshuler, L. Groop, C. Langenberg, N. Wareham, E. Sijbrands, C. V. van Duijn, J. Florez, J. Meigs, E. Boerwinkle, C. Gieger, K. Strauch, A. Metspalu, Andrew D. Morris, C. Palmer, F. Hu, U. Thorsteinsdóttir, K. Stefánsson, J. Dupuis, Andrew P. Morris, M. Boehnke, M. McCarthy, I. Prokopenko +174 moresemanticscholar +1 more sourcePhosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia +3 morewiley +1 more sourceGenome-Wide Association Study Reveals the Genetic Basis of Duck Plumage Colors [PDF]
, 2023 Xinye Zhang, Tao Zhu, Liang Wang, Xueze Lv, Weifang Yang, Changqing Qu, Haiying Li, Huie Wang, Zhonghua Ning, Lujiang Qu +9 moreopenalex +1 more source
