Results 71 to 80 of about 42,684,660 (287)
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure [PDF]
, 2011 Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans1, 2, 3. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = Döring, Angela, Klauw, M.M. van der, Wichmann HE, Preuss, M., Ridker, P.M., Trompet, S., Launer, L, Pfeufer, Arne, Boerwinkle, E., Anneli Pouta, Ongen, H. (Halit), Palmer, L.J., van der Klauw, MM (Melanie), Glazer, NL, Toshiko Tanaka, De Buyzere, Marc, Loos, Ruth J, John M Starr, Smith, AV, Toniolo, D. (Daniela), Lathrop, Mark, Alizadeh, Behrooz Z., Musk, A William, Preuss M, Navarro, Pau, Felix, J.F., A. William Musk, Trompet, S. (Stella), Corsi, A.M. (Anna Maria), Stefansson, K, Chambers, John C, Willemsen, G.A.H.M. (Gonneke), Najjar, SS, Gider, P., Smith AV, O'Donnell, CJ, Palmer, Lyle J., Nelson, C.P. (Christopher P.), Wichmann, H.E. (Heinz Erich), Xiaowen Lu, Kuehnel, Brigitte, Rose, Lynda M, Maris Laan, Igl, W., Harris, T.B. (Tamara), Toomas Haller, Cockcroft JR, Ongen, Halit, Voelker, Uwe, Faletra, F., Toniolo, D, Munroe, PB, de Geus, E.J., Maouche S, Attwood T, Rose, L.M. (Lynda), Rebecca J. Webster, Andrews JS, de Geus, Eco J C, Milaneschi, Y. (Yuri), Rivadeneira, F, Francesco U. S. Mattace Raso, Murray E, Assime TL, Strachan, David P., Johnson, T, Alizadeh, B.Z., Sinning C, Chen L, Shuldiner AR, Rudan, I. (Igor), CKDGen consortium, Orru, Marco, Ulivi, S, Starr, J.M. (John), AortaGen Consortium, the, Uitterlinden, Andre G, Lindeman, J.H. (Jan H.), et al., Peter Henneman, Lopez, L.M., Smith, A.V. (Albert Vernon), Quertermous T, Völker, U. (Uwe), Benjamin F. Voight, Tammesoo, M.L., Janssens, A.C., Rice, K.M., Zhang, W., Illig T, Levy, D. (Daniel), Taylor, K.D., Gyllensten, Ulf B, Najjar SS, V??lker, Uwe, Milaneschi, Y, Raitakari, Olli T., Vitart, Veronique, Völzke, H. (Henry), De Bacquer D, Emilsson, V., Hercberg, S., John C. Chambers, Musk, AW, Lucas, Gavin, Janssens, ACJW, Wright, A.F., Shin, SY, Hadley, D., Lloyd-Jones H, Burtt N, Jaakko Tuomilehto, O' Donnell CJ, Ulf B. Gyllensten, Shih Jen Hwang, Hung, J. (Judy), Wareham, N.J., Nelson, CP, Gary F. Mitchell, Scharnagl H, CardioGram, Wild, S.H. (Sarah), Heath, S., Zhang, F.F., Erdmann, Jeanette, Del Greco, Fabiola M., Li, XZ, Dehghan A, Gregory L. Burke, Xinzhong Li, Tim D Spector, Galan, P., Zhang, WH, Nolte, I.M. (Ilja), Ramachandran S Vasan, Jackson, A.U., Wilson, James F, Org, E, Ian J Deary, Völzke, H, Parker, AN, Schillert A, Hung, J, Hofman A, de Geus, EJC, Dobnig H, Erdmann, J, Wright, AF, Boban, M., Larson, Martin G., Najjar, Samer S., Hottenga, J.J., Herrington DM, Farrall, M. (Martin), Palmer, LJ, Hercberg, Serge, Kooner, J.S. (Jaspal), Albert V Smith, Cornelia M. van Duijn, Beckmann, Jacques S, Sijbrands, EJ, Susana Eyheramendy, Melander, O, Jacques S. Beckmann, Thorsteinsdottir, U, Polasek, Ozren, A Cecile J W Janssens, Ruth J F Loos, Medack A, Jarvelin, MR, Snieder, H. (Harold), Salomaa, V. (Veikko), van Duijn, Cornelia M., Behrooz Z. Alizadeh, Thorsteinsdottir, U. (Unnur), Groop, L. (Leif), Alanna C. Morrison, Trompet, Stella, Ehret, Georg B, Gavin Lucas, Renner W, Sõber, S. (Siim), Jackson, Anne U, Newton-Cheh, C, Snieder, Harold, Faletra, Flavio, Braund P, Barroso, Ines, Tim D. Spector, Collins, FS, Palmas, W, Thor Aspelund, Olli T. Raitakari, Rietzschel, Ernst, Zhao, JH, Hernandez, Dena, Nolte, IM, Ozren Polašek, Lu, X. (Xiaowen), Volzke, H., Barroso, In S., Vollenweider, P, Smith, A., Wilmar Igl, Pouta, A. (Anneli), Najjar, S.S. (Samer), Navarro, P. (Pau), Jaspal S. Kooner, Stolk, Ronald P, Esko, T. (Tõnu), Barroso, I.E. (Inês), Elliott, P., Li, X., Pirastu, N, Pistis, G, Fu, J.Y., Palmas, W., Tanaka, T, Cupples LA, Marjo-Riitta Jarvelin, Richard N Bergman, Psaty, Bruce M., Beilby, John P, Smith, N.L., Klauw, M.M. (Melanie) van der, Tuomilehto, J., Fu, J, Galan, P, Haller, T, Serge Hercberg, Marjo Riitta Jarvelin, Morrison, Alanna C, Germaine C. Verwoert, Gyllensten, Ulf B.,, Niblett D, Ehret, G.B., Holm H, Bis, J.C. (Joshua), Chasman, D.I. (Daniel), Faletra, F. (Flavio), Campbell, Harry, Foad N, Francesco U S Mattace-Raso, Voight, Benjamin F, Scott, J., Janssens, A Cecile J. W., Davies, G, Shin, S.Y., Dorret I Boomsma, Bochud, M., Hlatky M, Bergmann, S, Plump, A., Jacqueline C. M. Witteman, Lindeman, Jan H, Behrooz Z Alizadeh, Kari Stefansson, Gray E, Scott, J. (James), Khaw, KT, Schnabel R, Grosshennig A, Rotter JI, Hernandez, D.G. (Dena), Erdmann, J. (Jeanette), Chasman, DI, Pistis, G. (Giorgio), Vilmundur Gudnason, Absher D, Doering, Angela, Rao, Dabeeru C., Stott, D., Mattace-Raso, Francesco U S, Lathrop, G.M. (Mark), Mitchell, GF, Bis, J.C., Wilson, J.F., David Siscovick, Meisinger C, Samani, N.J., DeStefano, Anita L, van Duijn CM, Samani NJ, Feng Zhang, Beilby, JP, Anna Maria Corsi, Lorna M Lopez, Olli T Raitakari, Soranzo, N., Schmidt, H., Waeber, G., De Buyzere ML, Pouta, A., Kahonen, M., Mladen Boban, Raitakari, OT, Wichmann, HE, Preuss, Michael, Breteler, M, Pichler, Irene, Boban, Mladen, Hwang, S.J., DeStefano, A.L., Corsi, Anna Maria, O'Reilly, P.F., Antonella Fabretto, Bergmann, S., Maurizio Facheris, Rettig, R. (Rainer), Joseph Hung, Fabretto, A, Farrall, M., Siim Sõber, Ehret, Georg B., Deary, I.J., Laan, M, Emilsson, Valur, Gang Shi, Peden, John F., Doring, A., Vasan, RS, Beckmann, J.S. (Jacques), Larson MG, Willemsen, G.; id_orcid, Giorgio Pistis, Chambers, J.C., Khaw, Kay-Tee, Schmidt, R. (Reinhold), Navarro, P., Debette, St??phanie, Sijbrands, E.J.G. (Eric), Holm, H, Ganesh, Santhi K, Mitchell, Gary F., Samani, Nilesh J, d'Adamo, AP, Gasparini, Paolo, Tomaschitz A, Nelson CP, Boomsma, Dorret I., McArdle, W.L., Melander, O., Zitting, P. (Paavo), Newhouse SJ, Fischer M, Hayward, Caroline, Masciullo, Corrado, Hofman, A. (Albert), Erdmann J, Albert Hofman, Belz S, Voight, B.F., Kuhnel, B. (Brigitte), O'Leary K, Fornage, M, Igl, Wilmar, Segers P, Kühnel, Brigitte, Kroemer, H.K., Facheris, M.F. (Maurizio), Caulfield, MJ, Shin, So-Youn, Lyle J. Palmer, Winkler K, Schmidt, R., Kooner, JS, Mitchell, Gary F, Rebecca J Webster, Aspelund, T, Nelson, C.P., Mattace-Raso, FU, Oostra, B.A., Emilsson, V, Watkins, Hugh, Christian Gieger, Barroso, In??s, Greco, M.F. del, Shi, G. (Gang), KidneyGen Consortium, the, Buckley, B, O'Reilly, P.F. (Paul), Michael Boehnke, Spector, T.D., Sijbrands, E.J., Loos, R.J.F., Taylor, K.D. (Kent), Rice, Kenneth M, Larson, Martin G, Wilson, JF, Waeber, G, CHARGE Consortium Heart Failure, the, Webster, RJ, Gyllensten, U.B., Jemma C. Hopewell, Pollard H, de Geus, Eco J. C., Holm, H., Aulchenko, Yurii, Rupprecht HJ, Arora, P., Cinzia Sala, Münzel T, Pirastu, Nicola, Johnson, T. (Toby), Aulchenko, Yuriy, Wilson, J.F. (James), Meitinger, T. (Thomas), Leif Groop, Wain, Louise V, Bickel C, Hopewell, J.C., CardioGram,, Goncalo R Abecasis, Barbalic M, Rice, K. (Kenneth), KidneyGen consortium, Uda, M., Rivadeneira Ramirez, F. (Fernando), Böhm BO, Harris, Tamara B, d'Adamo, Adamo Pio, Morrison, A.C. (Alanna), Buckley, B., Gillebert TC, Campbell, H. (Harry), Caulfield, M. (Mark), Groop, L, Boehnke, M, Ruth J. F. Loos, Kathiresan S, Shi, Gang, Mari Liis Tammesoo, Knowles J, Kenneth M. Rice, Jewell E, Sidney S, Webster, Rebecca J, Levy D, Melander, Olle,, Peden, J. (John), Mitchell, G.F. (Gary), Sala, C, Kuhnel, B., Bochud, Murielle, Aspelund T, Parker, A.N. (Alex), Gasparini, P., Martin Farrall, Navarro, P, van Dijk, KW, Burke, Gregory L, Taylor KD, Wagner AK, Mooser, Vincent, Uitterlinden, AG, Tamara B Harris, Orru, M., Gieger, C, Ronald P Stolk, Haller, T. (Toomas), Levy, Daniel, Tamara B. Harris, Khaw, K-T. (Kay-Tee), Wichmann, H-Erich, Goel, Anuj, Watkins, H., Aspelund, T. (Thor), Buckley, Brendan, Lopez, Lorna M., Roberts R, Andersen K, Mark J. Caulfield, Yuri Milaneschi, Louise V Wain, van Duijn, CM, Starr, John M., Zhang, W.H., Paul M. Ridker, Jan H Lindeman, Melanie M van der Klauw, Ferrucci, L. (Luigi), Chasman, Daniel I, Stolk, RP (Ronald), Sõber, S, Nolte, IM (Ilja), Singleton, Andrew, Johnson, T., Salomaa, V, Webster, R.J., Felix, Janine, Daniela Toniolo, Lumley T, Eric J G Sijbrands, Siscovick, David, Mark Lathrop, Jaspal S Kooner, Liu Y, Soranzo, N. (Nicole), Esko, T??nu, Uda, Manuela, John P. Beilby, Scholz M, Breteler, M., Parker, Alex N., Dena Hernandez, Harris T, Francis S Collins, Snieder, H, Bergmann, Sven, Bergmann, S.M. (Sven), Daniel I. Chasman, Loos, R.J.F. (Ruth), Debette, S, Wareham, N.J. (Nick), Del Greco, F. (Fabiola), Burke, G.L., König IR, Lorna M. Lopez, Parsa A, Alavere, H. (Helene), Pola?ek O.,, Esko, T, Henneman, Peter, Nicholas J Wareham, Stefansson, K. (Kari), Hengstenberg C, Goel, A., 't Hoen, Peter A. C., Marco Orru, Vincent Mooser, van Dijk, K.W., Krishnan U, Risch N, Alizadeh, Behrooz Z, Wilkinson IB, Erdmann, J., Arora, Pankaj, Laitinen, J, Del Greco M, Fabiola, Boban, M, Simon Heath, Paavo Zitting, Marisa Loitfelder, Fabretto, Antonella, Lindeman, JH, Jukema, J.W., Schmidt, Helena, Lucas, G. (Gavin), Luigi Ferrucci, Corsi, A.M., Goncalo R. Abecasis, Tobin, Martin D, Deloukas P, H-Erich Wichmann, Inke R. König, Faletra, F, Benjamin EJ, Mooser, V. (Vincent), Loley C, Brenda W Penninx, CKDGen Consortium, the, Wain, L.V. (Louise), Musk, A.W. (Arthur), James Scott, Rankin A, Syvannen AC, Penninx, Brenda W., Beckmann, J.S., Janssens, A.C.J.W., Bruce M Psaty, Chambers, John C., Alizadeh, B.Z. (Behrooz), Penninx, B.W., Waeber, Gerard, John F Peden, Polasek, O., Dijk, K.W. van, Collins, Francis S., Schunkert H, Harris, TB, David Altshuler, Pilz S, Wareham, Nicholas J., Laitinen, Jaana, De Backer, Gui, Abecasis, GR, Oostra, B.A. (Ben), Wang, TJ, Tõnu Esko, Zhao, J.H., Eardman J, Vitart, V, Larson, M.G., Fortmann S, Hayward, C, Jennifer L. Bragg Gresham, Mattace-Raso, F.U., Chen IY, Post WS, Gyllensten, U. (Ulf), Strachan, DP, Vasan, R.S., Tanguy Corre, Glazer, N.L., Helena Schmidt, Van Bortel, Lucas, Spector, TD, Li, X.Z., Najjar, Samer S, Georg B. Ehret, Igor Rudan, Wain, L., Milaneschi, Y., Rietzschel ER, Debette, Stephanie, Benjamin F Voight, Siscovick, D.S. (David), Ferrucci, L., Van Bortel L, Jouke-Jan Hottenga, Uwe Völker, Bruce M. Psaty, Anita L DeStefano, Chen, Y.D.I. (Yii-Der Ida), Peden, JF, Uda, M. (Manuela), Lehtimäki, T, Strachan, David P, null null, Tammesoo, ML, Ilja M. Nolte, Pierre Meneton, Shi, G., Tiret L, Felix, Janine F, Heimerl S, Abecasis, G.R. (Gonçalo), Lakatta EG, Samani, Nilesh J., Flavio Faletra, Stéphanie Debette, Campbell, H, Pichler, I. (Irene), Fabretto, A., Marciante K, Hofman, Bert, Lindeman, Jan H., Hercberg, S. (Serge), Toniolo, D., De Bacquer, Dirk, Gillebert, Thierry, Watkins, H, Jukema, J Wouter, Eiriksdottir G, Ehret, Georg Benedikt, Mitchell, G.F., Hall A, Ferrucci, Luigi, Kenneth M Rice, Siscovick, D, Gary F Mitchell, Spector, Tim D., Sijbrands, Eric J G, Jorma Viikari, Witteman JC, Snieder, H., Ulivi, Sheila, Nicaud V, Kleber M, Kay-Tee Khaw, Fu, Jingyuan; id_orcid, Heyo K Kroemer, Pouta, Anneli, Meneton, Pierre, Sanna S, Gieger, C., Terho Lehtimäki, Pihur, Vasyl, Verwoert, G.C. (Germaine), Walter Palmas, Davies, G., Stolk, Ronald P., Ridker, Paul M, Mika Kähönen, Nicola Pirastu, Elliott, P. (Paul), Sven Bergmann, Gudmar Thorleifsson, Lenore Launer, O'Donnell, Christopher J., Richard N. Bergman, Lehtim??ki, Terho, Pola??ek, Ozren, Stella Trompet, Loitfelder, Marisa, Altshuler, D, Corre, T. (Tanguy), John P Beilby, Clarke, Robert, Patricia B Munroe, Chambers, JC, Mangino, Massimo, de Geus, E.J.C.; id_orcid, Irene Pichler, Lyle J Palmer, Verwoert, Germaine, Hadley, D, Lucas, G, Fu, JY, Elin Org, Wild, S.H., Clarke, R., Palmas, W. (Walter), Gonneke Willemsen, Abecasis, Goncalo R., Hamsten, A. (Anders), James F Wilson, Stefansson, K., Johnson, AD, Alan F Wright, Siscovick, D., Facheris, M., Massimo Mangino, Jingyuan Fu, Johnson, A., Halit Ongen, Willemsen, G, Caroline Hayward, Harris, Tamara B., Boomsma, D.I.; id_orcid, Ramachandran S. Vasan, 't Hoen, PAC, Fu, J., Gérard Waeber, Harry Campbell, Rice K, Strachan, D.P., Chen, Y.D.I., Inês Barroso, Jan H. Lindeman, Schmidt, R, Chen, YDI, Uitterlinden, André; id_orcid, Lieb W, Farrall, Martin, Uitterlinden A, Schmidt, H, Kahonen, Mika, Henry Völzke, Ben A Oostra, Veronique Vitart, Rivadeneira, F., Mooser, V, Viikari, J, Rudan, Igor, Christopher J. O'Donnell, Beckmann, Jacques S., Gulde S, Zitting, P., Zeginigg, M. (Marion), Launer, L., Ko Willems van Dijk, Crisp-Hihn A, Lathrop, M., Lopez, LM, Johnson, Toby, Anita L. DeStefano, Facheris, M, O'Donnell, Christopher J, A William Musk, Meitinger, T, Pirastu, N. (Nicola), Rettig, R., Tang H, Witteman, Jacqueline CM, Debette, S., Thorsteinsdottir, U., Grammer TB, Keis, A, Boomsma, DI, Hung, Joseph, Rainer Rettig, Mattace-Raso FU, Spector, Tim D, Chakravarti, A., Uitterlinden, A.G., Sarah H Wild, Sigurdsson S, Lu, X, Bekaert S, Ridker, P.M. (Paul), Abecasis GR, Järvelin, M.R., Psaty, BM, Ferrucci L, Holm, H. (Hilma), Org, Elin, Oostra BA, Willemsen, G., Melander, Olle, Plump, A.S. (Andrew), Glazer, Nicole L, Smith, NL, James F. Wilson, Boomsma, D.I., Psaty, B.M., Raitakari, O. (Olli), Hofman, A, van der Klauw, Melanie M, Galan, P. (Pilar), Rudan, I, Hopewell, JC, Doering A, LifeLines Cohort Study, the, Andrew D Johnson, Vitart, V., Beilby, John P., Stott, D, Döring, A, Isaacs A, Hopewell, J., Jouke Jan Hottenga, Witteman, J.C.M. (Jacqueline), Pilar Galan, Uda M, Jian'an Luan, Vollenweider, P. (Peter), Henneman, P., Wendy L McArdle, Nilesh J Samani, Luan, J.A., Hamsten, Anders, Henneman, P, Haller, T., Loos, Ruth JF, Burke, Gregory L., Boehnke, M., Vasan, Ramachandran S, Singleton, A, Parker, A.N., Snieder, Harold; id_orcid, Kundu, S, Fornage, Myriam, Corre, T, Amin, N. (Najaf), Fu, Jingyuan, Mangino, M., Bandinelli, S, Milaneschi, Yuri, Fu, J. (Jingyuan), Ongen, H, Nicole L Glazer, Rose, LM, Uitterlinden, Andre G., Rettig, Rainer, Reinhold Schmidt, Keis, Aime, Hung, J., Thorsteinsdottir U, Heath, S, Blankenberg S, Groop, L., Lu, X., Loos, Ruth J F, CHARGE Consortium Heart Failure, Hugh Watkins, Gasparini, P, Deary, Ian J, Altshuler, D., Goodall AH, Hofman, A., Sober, Siim, Smith, Albert V, Schmidt, Reinhold, Lindeman, J.H., Heyo K. Kroemer, Jarvelin, Marjo-Riitta, D??rr, Marcus, Voight, Benjamin F., Sijbrands, E.J.G.; id_orcid, König, I.R. (Inke), Gider, Pierre, David Stott, Ulivi, S. (Shelia), Bergman, R.N., Martin G Larson, K??hnel, Brigitte, Salomaa, Veikko, Bergman, Richard N., Collins, Francis S, König, Inke R., Kundu, S. (Suman), Lu, XW, Sala, Cinzia, Andres Metspalu, Debette, S. (Stéphanie), Guiducci C, EchoGen consortium, Deary, I.J. (Ian), Segers, Patrick, Andrew D. Johnson, de Geus, EJ, Valur Emilsson, Santhi K Ganesh, Laan, M., Lord, Graham, Kähönen, M, Hopewell, Jemma C., Nolte, Ilja M, Aravinda Chakravarti, Rice, Kenneth M., Chasman, Daniel I., Mark J Caulfield, Caulfield, M.J., Kooner, J.S., Fernando Rivadeneira, Gieger, C. (Christian), Launer LJ, Sijbrands, Eric JG, Sijbrands, EJG, Shih-Jen Hwang, Mangino, M, Schmitz G, Kooner, Jaspal S, Daniel I Chasman, Pihur, V., Beilby, J.P. (John), Newman AB, Nicholas J. Wareham, Germaine C Verwoert, Loos, Ruth J. F., Paul F O'Reilly, Sie MP, Heath, S.C. (Simon), Corrado Masciullo, Gwilliams R, Duijn, C.M. van, Angela Döring, Loos, RJF, Munroe, Patricia B., Harris TB, Cupples L, Nolte, Ilja M.; id_orcid, Proust C, Collins, F.S., Scott, J, CHARGE Consortium Heart Failure Working Group, Palmer, Lyle J, O'Donnell, C.J. (Christopher), van der Klauw, MM, Yasmin, Schroeder L, Kong A, Stott, D.J. (David. J.), Verwoert, Germaine C, Holm, Hilma, Rao, D.C. (Dabeeru C.), Hottenga, JJ (Jouke Jan), Pfeufer, A. (Arne), Alex N. Parker, Breteler, M.M.B. (Monique), Toby Johnson, Ganesh, Santhi K., Van Duijn, Volker, U., De Meyer T, Stott, D.J., Bergman, RN, Vasan, Ramachandran S., Johnson AD, Musunuru K, Bragg-Gresham, JL, Louise V. Wain, Eco J C de Geus, Wright, A.F. (Alan), Jing Hua Zhao, McArdle, W.L. (Wendy), Hadley, D. (David), Melander, O. (Olle), Vitart, V. (Veronique), Luan, J., Janine F. Felix, Psaty, B.M. (Bruce), Wild, Sarah H, Fabiola Del Greco M, 't Hoen, Peter AC, Stott, David, Zeginigg, M, Ulivi, S., Rudan, I., Thomas J. Wang, Christopher P Nelson, Joshua C Bis, Eyheramendy, Susana, Wilson, James F., Sala, C. (Cinzia), Smith, Nicholas L., Keis, A., Myriam Fornage, Oostra, Ben A +999 morecore +2 more sourcesStructure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.Alex J. Vecchiowiley +1 more sourceImproved heritability estimation from genome-wide SNPs [PDF]
, 2012 Narrow-sense heritability (h(2)) is an important genetic parameter that quantifies the proportion of phenotypic variance in a trait attributable to the additive genetic variation generated by all causal variants.Johnson, Michael R., Balding, DJ, Hemani, G, Hemani, Gibran, Balding, David J., Speed, D, Johnson, MR, Speed, Doug +7 morecore +1 more sourceA genome-wide interaction study of thyroid-stimulating hormone levels and particulate matter exposure among Koreans
Genes and EnvironmentBackground Although the associations between air pollution exposure and thyroid function have been reported, the interactive effects of the genes involved remain unknown. Therefore, we aimed to identify candidate genetic loci involved in thyroid function Young Jun Park, Hyun-Jin Kim, Ho-Young Son, Juhyun Kim, Jae Moon Yun, Hyuktae Kwon, Belong Cho, Jin-Ho Park, Jong-Il Kim +8 moredoaj +1 more sourceLiver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses Anna M. Dowbaj, Meritxell Huchwiley +1 more sourceNot so benign
eLife, 2018 Susceptibility to uterine fibroids, benign tumors that affect the health of many women, is linked to genes that are responsible for preserving genome integrity and promoting genitourinary development.Barbara Riveradoaj +1 more sourceLigand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada +5 morewiley +1 more source
