Results 91 to 100 of about 42,684,660 (287)

Genome-wide association studies for transpiration efficiency and physiological traits in Ethiopian Sorghum genotypes

open access: yesScientific Reports
Sorghum (Sorghum bicolor L. Moench) is a drought-tolerant crop, with its resilience essentially attributed to high transpiration efficiency (TE), and simply defined as the biomass produced per unit of water transpired.
Yirgalem Tsehaye   +7 more
doaj   +1 more source

Association between human blood metabolome and the risk of delirium: a Mendelian Randomization study

open access: yesFrontiers in Endocrinology
BackgroundDelirium significantly contributes to both mortality and morbidity among hospitalized older adults. Furthermore, delirium leads to escalated healthcare expenditures, extended hospital stays, and enduring cognitive deterioration, all of which ...
Chubing Long   +21 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis [PDF]

open access: yes, 2011
Objectives: To investigate if potential common pathways exist for the pathogenesis of autoimmune disease and prostate cancer (PrCa). To ascertain if the single nucleotide polymorphisms (SNPs) reported by genome-wide association studies (GWAS) as being ...
Donovan, Jenny   +57 more
core   +1 more source

Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors

open access: yesPharmacogenomics and Personalized Medicine, 2021
Zixiu Zhou, Sizhen Li, Qingsong Yang, Xiaodong Yang, Kuanxiao Hao, Yating Liu, Shanshan Xu Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, 211102, People’s Republic of ChinaCorrespondence: Sizhen LiNanjing Tongren ...
Zhou Z   +6 more
doaj  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. [PDF]

open access: yes, 2011
Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam.
Tuan, NM   +109 more
core   +1 more source

A Genome-Wide Association Study for Calving Interval in Holstein Dairy Cows Using Weighted Single-Step Genomic BLUP Approach

open access: yesAnimals, 2020
The aim of the present study was to identify genomic region(s) associated with the length of the calving interval in primiparous (n = 6866) and multiparous (n = 5071) Holstein cows.
Hadi Atashi   +6 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function [PDF]

open access: yes, 2011
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 ...
Stricker, Bruno H. Ch   +903 more
core   +1 more source

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