Results 51 to 60 of about 851,678 (251)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Genome- and epigenome-wide association studies identify susceptibility of CpG sites and regions for metabolic syndrome in a Korean population

Clinical Epigenetics
Background While multiple studies have investigated the relationship between metabolic syndrome (MetS) and its related traits (fasting glucose, triglyceride, HDL cholesterol, blood pressure, waist circumference) and DNA methylation, our understanding of ...
Ho-Sun Lee, Boram Kim, Taesung Park
doaj   +1 more source

Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. [PDF]

, 2015
Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive thoughts and urges and repetitive, intentional behaviors that cause significant distress and impair functioning.
Askland, KD, Bienvenu, OJ, Cullen, BA, Fyer, AJ, Geller, DA, Goes, FS, Grados, MA, Greenberg, BD, Knowles, JA, Lange, C, Liang, K-Y, Maher, B, Mattheisen, M, McCracken, JT, McLaughlin, NC, Murphy, DL, Nestadt, G, Nurmi, EL, Pauls, DL, Piacentini, J, Pulver, AE, Qin, H-D, Rasmussen, SA, Riddle, MA, Samuels, JF, Shugart, YY, Stewart, SE, Valle, D, Wang, Y   +28 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Not so benign

eLife, 2018
Susceptibility to uterine fibroids, benign tumors that affect the health of many women, is linked to genes that are responsible for preserving genome integrity and promoting genitourinary development.
Barbara Rivera
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A genome-wide association study demonstrates significant genetic variation for fracture risk in Thoroughbred racehorses [PDF]

, 2014
Background: Thoroughbred racehorses are subject to non-traumatic distal limb bone fractures that occur during racing and exercise. Susceptibility to fracture may be due to underlying disturbances in bone metabolism which have a genetic cause.
Blott, Sarah C., Fox-Clipsham, Laura Y, Helwegen, Maud, Hillyer, Lynn, Newton, J., Parkin, Tim D.H., Sibbons, Charlene, Swinburne, June E, Vaudin, Mark   +8 more
core   +4 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

A genomic‐based vision on the genetic diversity and key performance traits in selectively bred Arctic charr (Salvelinus alpinus)

Evolutionary Applications, 2022
Routine implementation of genomic information for guiding selection decisions is not yet common in the majority of aquaculture species. Reduced representation sequencing approaches offer a cost‐effective solution for obtaining genome‐wide information in ...
Christos Palaiokostas, Anam Anjum, Henrik Jeuthe, Khrystyna Kurta, Fernando Lopes Pinto, Dirk Jan deKoning   +5 more
doaj   +1 more source

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. [PDF]

, 2009
Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data ...
Abraham, Clara, Achkar, Jean-Paul, Annese, Vito, Barmada, M Michael, Bayless, Theodore M, Bossa, Fabrizio, Brant, Steven R, Cho, Judy H, Daly, Mark J, Duerr, Richard H, Goyette, Philippe, Gregersen, Peter K, Griffiths, Anne M, Ippoliti, Andrew F, Kistner, Emily O, Klei, Lambertus, Lahaie, Raymond G, Latiano, Anna, Lee, Annette T, McGovern, Dermot PB, Paré, Pierre, Proctor, Deborah D, Regueiro, Miguel D, Rioux, John D, Roeder, Kathryn, Rotter, Jerome I, Schumm, L Philip, Scott, Regan, Silverberg, Mark S, Steinhart, A Hillary, Targan, Stephan R, Taylor, Kent D, Wu, Jing, Xu, Wei   +33 more
core