Results 41 to 50 of about 851,678 (251)

Genome-wide association study of sleep in Drosophila melanogaster [PDF]

, 2013
BACKGROUND: Sleep is a highly conserved behavior, yet its duration and pattern vary extensively among species and between individuals within species. The genetic basis of natural variation in sleep remains unknown. RESULTS: We used the Drosophila Genetic
Lenovia J McCoy, Susan T Harbison, Trudy FC Mackay   +2 more
core   +1 more source

Genetic differences according to onset age and lung function in asthma: A cluster analysis

Clinical and Translational Allergy, 2023
Background The extent of differences between genetic risks associated with various asthma subtypes is still unknown. To better understand the heterogeneity of asthma, we employed an unsupervised method to identify genetic variants specifically associated
Han‐Kyul Kim, Ji‐One Kang, Ji Eun Lim, Tae‐Woong Ha, Hae Un Jung, Won Jun Lee, Dong Jun Kim, Eun Ju Baek, Ian M. Adcock, Kian Fan Chung, Tae‐Bum Kim, Bermseok Oh   +11 more
doaj   +1 more source

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. [PDF]

, 2017
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability.
Banda, Yambazi, Choquet, Hélène, Hoffmann, Thomas J, Jorgenson, Eric, Kvale, Mark N, Melles, Ronald, Nair, K Saidas, Risch, Neil, Schaefer, Catherine, Thai, Khanh K, Yin, Jie   +10 more
core   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Using Ontology Fingerprints to evaluate genome-wide association study results [PDF]

, 2009
We describe an approach to characterize genes or phenotypes via ontology fingerprints which are composed of Gene Ontology (GO) terms overrepresented among those PubMed abstracts linked to the genes or phenotypes. We then quantify the biological relevance
Lam C. Tsoi, Michael Boehnke, Richard L. Klein, W. Jim Zheng   +3 more
core   +1 more source

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. [PDF]

, 2013
Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia.
A D Børglum, A Hedemand, A Ludwig, A Miyashita, A Terracciano, A Uitterlinden, AC Need, AC Ravanpay, AD Skol, AG Cardno, AR Fisher, AR Morgan, AS Brown, AS Brown, AS Yap, B Janssens, B Nørgaard-Pedersen, B Xu, BH Shirts, BJ Fredette, BM Gumbiner, BM Neale, BM Neale, C B Pedersen, C Ciatto, C Wiuf, CB Pedersen, CE Murcray, CM Nievergelt, D Demontis, D Demontis, D M Hougaard, D Moreno-De-Luca, DB Boivin, GR Abecasis, H Le-Niculescu, H Stefansson, H Stefansson, HA Mansour, HA Mansour, HC So, I Sousa, J Grove, J Lasky-Su, J Majercak, J Novembre, J Pallesen, J Shi, J van Os, J Yang, JA Embil, JE Buizer-Voskamp, JJ Kim, K Wang, K Wulff, K Zhou, KH Baratz, KP Lesch, L Athanasiu, LN Moens, M Didriksen, M M Nöthen, M Mattheisen, M Nordentoft, M Nyegaard, M Nyegaard, M Rietschel, M Rietschel, M Scholz, M Takeichi, M Takeichi, M V Hollegaard, ML Rao, MS Keshavan, MV Hollegaard, N Cermakian, N Patterson, O Mors, O Mors, P B Mortensen, PA Holmans, PB Mortensen, PF Sullivan, R A Ophoff, R H Yolken, R Steinberg, RL Schelonka, S Cichon, S Purcell, S Ripke, S Steinberg, SA Riazuddin, SA Staras, SH Lee, SJ Sanders, SL Buka, SL Buka, SM Purcell, T Miyoshi, T Takeuchi, T Ørntoft, TJ Crow, TL Edwards, V Busby, V Soria, VR Sobrado, X Liang, Y Adachi, Y Li   +108 more
core   +4 more sources

Genome-wide association study identifies 30 loci associated with bipolar disorder. [PDF]

, 2019
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional
Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D, Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A, Barchas, Jack D, Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E, Boks, Marco P, Boocock, James, Breen, Gerome, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Byrne, Enda M, Bækvad-Hansen, Marie, Bøen, Erlend, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W, Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coleman, Jonathan RI, Coryell, William, Craig, David W, Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M, Dale, Anders M, de Jong, Simone, de Leeuw, Christiaan A, Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J Raymond, Djurovic, Srdjan, Dobbyn, Amanda L, Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B, Flickinger, Matthew, Foroud, Tatiana M, Forstner, Andreas J, Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B, Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Gaspar, Héléna A, Giambartolomei, Claudia, Goldstein, Jaqueline, Gordon, Scott D, Gordon-Smith, Katherine, Green, Elaine K, Green, Melissa J, Greenwood, Tiffany A, Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L, Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Holmans, Peter A, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S, Juréus, Anders, Mattheisen, Manuel, McQuillin, Andrew, Pavlides, Jennifer M Whitehead, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Pers, Tune H, Richards, Alexander L, Ripke, Stephan, Stahl, Eli A, Steinberg, Stacy, Trubetskoy, Vassily, Trzaskowski, Maciej, Wang, Yunpeng   +99 more
core  

Genome-wide association study of endometrial cancer in E2C2 [PDF]

, 2013
Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women.
Alison M. Dunning, Amanda B. Spurdle, Amanda Black, Anthony M. Magliocco, Brian E. Henderson, Carlotta Sacerdote, Christine M. Friedenreich, Christopher Haiman, Chu Chen, Constance Chen, David J. Hunter, David VanDen Berg, Deborah Thompson, Douglas F. Easton, Elizabeth Holliday, Fredrick Schumacher, Hannah P. Yang, Harvey Risch, Herbert Yu, Immaculata De Vivo, Irene Orlow, Jennifer Doherty, Jennifer Prescott, Jirong Long, Jodie N. Painter, John Attia, Jolanta Lissowska, Linda S. Cook, Lingeng Lu, Loic Le Marchand, Loreall Pooler, Louise Brinton, Lucy Xia, Mark McEvoy, Marta Crous-Bou, Mia M. Gaudet, Montserrat Garcia-Closas, Nicolas Wentzensen, Noel S. Weiss, null null, Pamela L. Horn-Ross, Patricia Hartge, Peter Kraft, Radhai Rastogi, Rodney J. Scott, Sara H. Olson, Stephen Chanock, Susan E. Hankinson, Timothy R. Rebbeck, Tracy A. O’Mara, Veronica Wendy Setiawan, Wei Zheng, Xiao-ou Shu, Xiaolin Liang, Xin Sheng, Yong-Bing Xiang   +55 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source