Results 41 to 50 of about 40,696,798 (92)

Improved heritability estimation from genome-wide SNPs [PDF]

open access: yes, 2012
Narrow-sense heritability (h(2)) is an important genetic parameter that quantifies the proportion of phenotypic variance in a trait attributable to the additive genetic variation generated by all causal variants.
Johnson, Michael R.   +7 more
core   +1 more source

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function [PDF]

open access: yes, 2011
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 ...
Stricker, Bruno H. Ch   +902 more
core   +1 more source

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension [PDF]

open access: yes, 2010
Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%–2% of the population variation in BP and hypertension.
Zanchetti A   +591 more
core   +4 more sources

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies [PDF]

open access: yes, 2012
<p>Background - Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less.
Furie, K.   +403 more
core   +2 more sources

Genome-wide association and functional follow-up reveals new loci for kidney function [PDF]

open access: yes, 2012
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new
Döring, Angela   +999 more
core   +2 more sources

Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. [PDF]

open access: yes, 2011
Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam.
Simmons, C   +119 more
core   +1 more source

Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function [PDF]

open access: yes, 2014
Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.
Wenbo Tang (110161)   +617 more
core   +2 more sources

Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment [PDF]

open access: yes, 2014
Specific language impairment (SLI) is a neurodevelopmental disorder that affects linguistic abilities when development is otherwise normal. We report the results of a genome-wide association study of SLI which included parent-of-origin effects and child ...
Newbury, Dianne F   +78 more
core   +1 more source

Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array [PDF]

open access: yes, 2009
The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans.
Döring, Angela   +183 more
core   +1 more source

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]

open access: yes, 2015
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs.
Seedorf, Udo   +928 more
core   +1 more source

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