Results 21 to 30 of about 40,696,798 (92)

A genome-wide association search for type 2 diabetes genes in African Americans. [PDF]

open access: yes, 2012
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.
Kumari, Meena   +389 more
core   +3 more sources

Genome-Wide Association Studies of the PR Interval in African Americans [PDF]

open access: yes, 2011
The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races.
Paltoo, Dina N.   +181 more
core   +1 more source

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis [PDF]

open access: yes, 2009
The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration.
Sendtner, M.   +461 more
core   +2 more sources

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process [PDF]

open access: yes, 2014
Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of ...
Springelkamp, H   +667 more
core   +6 more sources

A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain [PDF]

open access: yes, 2014
Background: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients.
Palmer, C. N. A.; id_orcid   +21 more
core   +1 more source

Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importnace of Lp(a) [PDF]

open access: yes, 2012
We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and the ...
Postmus, Iris   +65 more
core   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

open access: yes, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C   +9 more
core  

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA [PDF]

open access: yes, 2012
Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.
Palmer Cameron D.   +353 more
core   +3 more sources

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke [PDF]

open access: yes, 2012
Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of ...
Furie, K.   +455 more
core   +2 more sources

A genome-wide association study identifies protein quantitative trait loci (pQTLs) [PDF]

open access: yes, 2008
There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those mRNA transcripts - cis effects, and ...
Marjo-Riitta Jarvelin   +197 more
core   +1 more source

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