Results 11 to 20 of about 851,678 (251)

Transcriptome-wide association study identified candidate genes associated with gut microbiota

Gut Pathogens, 2021
Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities.
Chuyu Pan, Yujie Ning, Yumeng Jia, Shiqiang Cheng, Yan Wen, Xuena Yang, Peilin Meng, Chun’e Li, Huijie Zhang, Yujing Chen, Jingxi Zhang, Zhen Zhang, Feng Zhang   +12 more
doaj   +1 more source

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change. [PDF]

, 2020
In pharmacogenomic studies of quantitative change, any association between genetic variants and the pretreatment (baseline) measurement can bias the estimate of effect between those variants and drug response.
Haldar, Tanushree, Hoffmann, Thomas J, Iribarren, Carlos, Krauss, Ronald M, Medina, Marisa W, Oni-Orisan, Akinyemi, Ranatunga, Dilrini K, Risch, Neil, Schaefer, Catherine   +8 more
core   +2 more sources

Common variants in FOXP1 are associated with generalized vitiligo [PDF]

, 2010
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent,
A Alkhateeb, Alain Taïeb, Andreas Overbeck, Anthony P Weetman, C Shi, Christina M Mailloux, David J Gawkrodger, DF Luo, Dorothy C Bennett, E Helen Kemp, Giovanni Leone, H Hu, HD Ochs, JC Barrett, Jo Lambert, Katherine Gowan, Khaled Ezzedine, Margaret R Wallace, Mauro Picardo, Nanny van Geel, Pamela R Fain, Paulene J Holland, RA Spritz, Richard A Spritz, RM Salazar-Gonzalez, S Horvath, S Purcell, SA Birlea, Sheri L Riccardi, Stanca A Birlea, Thomas Jouary, Wayne T McCormack, X Feng, Y Jin, Ying Jin   +34 more
core   +2 more sources

Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer

Cancer Medicine, 2018
Aim To identify novel candidate genes for pancreatic cancer. Methods We performed a transcriptome‐wide association study (TWAS) analysis of pancreatic cancer (PC).
Liuyun Gong, Dan Zhang, Yutiantian Lei, Yuanjie Qian, Xinyue Tan, Suxia Han   +5 more
doaj   +1 more source

A Pooled Genome-Wide Association Study of Asperger Syndrome. [PDF]

, 2015
Asperger Syndrome (AS) is a neurodevelopmental condition characterized by impairments in social interaction and communication, alongside the presence of unusually repetitive, restricted interests and stereotyped behaviour.
Allison, Carrie, Baron-Cohen, Simon, Chakrabarti, Bhismadev, Chan, Allen, Craig, Ian, Fisher, Simon E, Lakatošová, Silvia, Mallya, Uma, Murphy, Laura, Peltonen, Leena, Rehnstrom, Karola, Warrier, Varun, Wheelwright, Sally   +12 more
core   +15 more sources

Genome-wide association study of Tourette Syndrome [PDF]

, 2014
Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we
Anderson, Kelley, Barr, Cathy L, Benarroch, Fortu, Berrío, Gabriel Bedoya, Bruun, Ruth D., Budman, Cathy L., Campbell, Desmond, Cath, Danielle C, Chouinard, Sylvain, Conti, David V., Cox, Nancy J., Crane, Jacquelyn, Crenshaw, Andrew T., Davarya, Sarah, Davis, Lea K, Dion, Yves, Duarte, Ana V. Valencia, Edlund, Christopher K., Erenberg, Gerald, Eskin, Eleazar, Evans, Patrick, Fagerness, Jesen A, Fernandez, Thomas, Fournier, Eduardo, Freimer, Nelson, Gamazon, Eric, Gibbs, J. Raphael, Gilbert, Donald L., Girard, Simon, Grados, Marco A., Gross-Tsur, Varda, Han, Buhm, Hardy, John, Heiman, Gary A., Herrera, Luis Diego, Heutink, Peter, Hoekstra, Pieter J., Illmann, Cornelia, Jankovic, Joseph, Kidd, Judith R., Kidd, Kenneth K., King, Robert A., Knowles, James A., Konkashbaev, Anuar, Kremeyer, Barbara, Kurlan, Roger, Leckman, James F., Lee, Paul C, Leppert, Mark, Liu, Chunyu, Lowe, Thomas L., Lyon, Gholson J, Mathews, Carol A., McMahon, William, Mirel, Daniel B., Moessner, Rainald, Moorjani, Priya, Morgan, Jubel, Muller, Heike, Naarden, Allan L, Neale, Benjamin M., Ochoa, William Cornejo, Oostra, Ben A., Ophoff, Roel, Osiecki, Lisa, Pakstis, Andrew J., Parkin, Melissa A., Pauls, David L., Phan, Nam, Pluzhnikov, Anna, Pollak, Yehuda, Posthuma, Danielle, Purcell, Shaun, Rangel-Lugo, Martha, Restrepo, Sandra C. Mesa, Reus, Victor I., Robertson, Mary M., Romero, Roxana, Rouleau, Guy A., Ruiz-Linares, Andres, Sabatti, Chiara, Sandor, Paul, Scharf, Jeremiah M., Service, Susan, Silgado, Julio C. Cardona, Singer, Harvey, Singleton, Andrew, Smit, Jan H, State, Matthew, Stewart, S. Evelyn, Strengman, Eric, Tikhomirov, Anna, Tischfield, Jay A., Wagner, Michael, Walkup, John, Weiss, Nicholas, Weiss, Robert, Yu, Dongmei   +97 more
core   +1 more source

Data mining and machine learning approaches for the integration of genome-wide association and methylation data: methodology and main conclusions from GAW20

BMC Genetics, 2018
Background Multiple layers of genetic and epigenetic variability are being simultaneously explored in an increasing number of health studies. We summarize here different approaches applied in the Data Mining and Machine Learning group at the GAW20 to ...
Burcu Darst, Corinne D. Engelman, Ye Tian, Justo Lorenzo Bermejo   +3 more
doaj   +1 more source

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

Human Genomics, 2019
Background While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal genes at these regions and
Molly Went, Ben Kinnersley, Amit Sud, David C. Johnson, Niels Weinhold, Asta Försti, Mark van Duin, Giulia Orlando, Jonathan S. Mitchell, Rowan Kuiper, Brian A. Walker, Walter M. Gregory, Per Hoffmann, Graham H. Jackson, Markus M. Nöthen, Miguel Inacio da Silva Filho, Hauke Thomsen, Annemiek Broyl, Faith E. Davies, Unnur Thorsteinsdottir, Markus Hansson, Martin Kaiser, Pieter Sonneveld, Hartmut Goldschmidt, Kari Stefansson, Kari Hemminki, Björn Nilsson, Gareth J. Morgan, Richard S. Houlston   +28 more
doaj   +1 more source

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Breast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J. Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L. Hopper, Melissa C. Southey, Tu Nguyen-Dumont, Tuong L. Nguyen, Peter A. Fasching, Annika Behrens, Gemma Cadby, Rachel A. Murphy, Kristan Aronson, Anthony Howell, Susan Astley, Fergus Couch, Janet Olson, Roger L. Milne, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Stacey Winham, Esther M. John, Allison Kurian, Heather Eliassen, Irene Andrulis, D. Gareth Evans, William G. Newman, Per Hall, Kamila Czene, Anthony Swerdlow, Michael Jones, Marina Pollan, Pablo Fernandez-Navarro, Daniel S. McConnell, Vessela N. Kristensen, NBCS Investigators, Joseph H. Rothstein, Pei Wang, Laurel A. Habel, Weiva Sieh, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Gretchen L. Gierach, Rulla M. Tamimi, Celine M. Vachon, Sara Lindström   +56 more
doaj   +1 more source

Genome-Wide Association Study and Pathway-Level Analysis of Kernel Color in Maize. [PDF]

, 2019
Rapid development and adoption of biofortified, provitamin A-dense orange maize (Zea mays L.) varieties could be facilitated by a greater understanding of the natural variation underlying kernel color, including as it relates to carotenoid biosynthesis ...
Diepenbrock, Christine H, Gore, Michael A, Mateos-Hernandez, Maria, Mathew, Deepu, Owens, Brenda F, Rocheford, Torbert, Tiede, Tyler, Wu, Di   +7 more
core   +2 more sources