Results 31 to 40 of about 851,678 (251)

From Gene Expression to Transcriptome-wide Association Study: Development and Comparison of Methodology

Xiehe Yixue Zazhi
Over the past two decades, genome-wide association study(GWAS) has identified numerous genetic variants and loci associated with heritable diseases. With the gradual maturation and saturation of GWAS methodologies, transcriptome-wide association study ...
FANG Kun, LI Guozhuang, WANG Linting, LI Qing, XU Kexin, ZHAO Lina, WU Zhihong, ZHANG Jianguo, WU Nan   +8 more
doaj   +1 more source

Genome-wide Association Study of Chicken Plumage Pigmentation [PDF]

Asian-Australasian Journal of Animal Sciences, 2013
To increase plumage color uniformity and understand the genetic background of Korean chickens, we performed a genome-wide association study of different plumage color in Korean native chickens. We analyzed 60K SNP chips on 279 chickens with GEMMA methods
Mi Na Park, Jin Ae Choi, Kyung-Tai Lee, Hyun-Jeong Lee, Bong-Hwan Choi, Heebal Kim, Tae-Hun Kim, Seoae Cho, Taeheon Lee   +8 more
doaj   +1 more source

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes. [PDF]

, 2017
ObjectiveTo determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples.MethodsFor this study ...
Barcellos, Lisa F, Cole, Michael, Criswell, Lindsey A, Firestein, Gary S, Graf, John, Halperin, Eran, Harrison, Ruby, Holingue, Calliope, Link, Thomas, Quach, Diana, Quach, Hong L, Rahmani, Elior, Rhead, Brooke, Shah, Khooshbu, Shao, Xiaorong, Sinclair, Elizabeth, Wang, Wei   +16 more
core   +1 more source

Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies

Frontiers in Medicine
IntroductionAlthough genome-wide association studies (GWAS) have identified multiple genetic loci linked to intervertebral disc disorder (IDD), their functional characterization remains largely unelucidated.
Zhe Zhang, Zhe Zhang, Yu Chen, Qianjin Wang, Zheng Li, Bingyang Dai, Bingyang Dai, Cheng Dong, Cheng Dong, Zhengya Zhu   +9 more
doaj   +1 more source

Exploring quantitative traits-associated copy number deletions through reanalysis of UK10K consortium whole genome sequencing cohorts

BMC Genomics, 2023
Objectives We performed comprehensive association analyses of common high-confidence gnomAD-reported copy number deletions (CNDs) with 60 quantitative traits from UK10K consortium WGS data.
Sejoon Lee, Jinho Kim, Jung Hun Ohn
doaj   +1 more source

Psoriasis: An Immunogenetic Perspective

Global Medical Genetics, 2022
Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease.
Ayca Kocaaga, Mustafa Kocaaga
doaj   +1 more source

Multicentric Genome-Wide Association Study for Primary Spontaneous Pneumothorax [PDF]

, 2016
Despite elevated incidence and recurrence rates for Primary Spontaneous Pneumothorax (PSP), little is known about its etiology, and the genetics of idiopathic PSP remains unexplored.
Abrantes, P, Feijó, S, Fradinho, M, Francisco, V, Malheiro, F, Monteiro, M, Moura E Sá, J, Negrão, L, Neves, J, Norte, A, Oliveira, M, Oliveira, SA, Reis, E, Robalo-Cordeiro, C, Santos, P, Sousa, I, Sousa, S, Teixeira, G   +17 more
core   +2 more sources

Progress of genome wide association study in domestic animals [PDF]

, 2012
Domestic animals are invaluable resources for study of the molecular architecture of complex traits. Although the mapping of quantitative trait loci (QTL) responsible for economically important traits in domestic animals has achieved remarkable results ...
Hui Li, Hui Zhang, Shouzhi Wang, Zhipeng Wang   +3 more
core   +1 more source

Genome-Wide Association Study of Hepatitis in Korean Populations [PDF]

Genomics & Informatics, 2014
Hepatitis is a common and serious disease for the Korean population. It is caused by a virus, the A and B types of which are plentiful in Koreans. In this study, we tried to find genetic factors for hepatitis through genome-wide association studies.
Youngbok Hong, Sejong Oh
doaj   +1 more source

Genomic characterization and phylogenetic analysis of Salmonella enterica serovar Javiana [PDF]

PeerJ, 2020
Salmonella enterica serovar Javiana is the fourth most reported serovar of laboratory-confirmed human Salmonella infections in the U.S. and in Tennessee (TN). Although Salmonella ser.
Lauren K. Hudson, Lisha Constantine-Renna, Linda Thomas, Christina Moore, Xiaorong Qian, Katie Garman, John R. Dunn, Thomas G. Denes   +7 more
doaj   +2 more sources