Results 31 to 40 of about 40,696,798 (92)

Genome-wide associate study identifies five new schizophrenia loci [PDF]

open access: yes, 2011
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent ...
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
core   +1 more source

Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis [PDF]

open access: yes, 2011
Objectives: To investigate if potential common pathways exist for the pathogenesis of autoimmune disease and prostate cancer (PrCa). To ascertain if the single nucleotide polymorphisms (SNPs) reported by genome-wide association studies (GWAS) as being ...
Donovan, Jenny   +58 more
core   +1 more source

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure [PDF]

open access: yes, 2011
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans1, 2, 3. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N =
Döring, Angela   +999 more
core   +2 more sources

A Genome-Wide Association Study Identifies Genomic Regions for Virulence in the Non-Model Organism Heterobasidion annosum ss [PDF]

open access: yes, 2013
The dense single nucleotide polymorphisms (SNP) panels needed for genome wide association (GWA) studies have hitherto been expensive to establish and use on non-model organisms.
Brandström Durling, Mikael   +24 more
core   +3 more sources

A genome-wide association search for type 2 diabetes genes in African Americans [PDF]

open access: yes, 2011
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.
Bostrom, Meredith A   +999 more
core   +5 more sources

A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels [PDF]

open access: yes, 2009
The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n =
Stewart, A.F.R.   +505 more
core   +2 more sources

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes [PDF]

open access: yes, 2014
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies ...
Rasmussen-Torvik, Laura J.   +585 more
core   +2 more sources

Evaluation of association of HNF1B variants with diverse cancers : collaborative analysis of data from 19 genome-wide association studies [PDF]

open access: yes, 2010
Background Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk.
Tomlinson, IP   +280 more
core   +1 more source

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci [PDF]

open access: yes, 2010
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which ...
Taylor JA   +611 more
core   +2 more sources

Genome-wide scanning versus candidate gene approach in the genetic architecture of common diseases. [PDF]

open access: yes, 2007
In the Nature 7 June issue, researchers from the Welcome Trust Case Control Consortium (WTCCC) reported the findings of a large genome-wide association (GWA) study of 14,000 cases of common diseases and 3000 controls studies revealing the role of several
Silvia Sookoian, Carlos J. Pirola
core   +1 more source

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