Results 121 to 130 of about 3,091,688 (344)
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
Nature Genetics, 2021 D. Wightman, I. Jansen, J. Savage, A. Shadrin, S. Bahrami, D. Holland, A. Rongve, S. Børte, B. Winsvold, O. K. Drange, Amy E. Martinsen, A. Skogholt, C. Willer, G. Bråthen, Ingunn Bosnes, J. Nielsen, L. Fritsche, Laurent F. Thomas, L. Pedersen, M. Gabrielsen, M. B. Johnsen, T. W. Meisingset, Wei Zhou, P. Proitsi, A. Hodges, Richard J. B. Dobson, L. Velayudhan, K. Heilbron, A. Auton, Michelle Stella Elizabeth Robert K. Jessica Katarzyna Emily Agee Aslibekyan Babalola Bell Bielenberg Bryc Bull, M. Agee, S. Aslibekyan, Elizabeth Babalola, R. Bell, Jessica Bielenberg, K. Bryc, Emily Bullis, Briana Cameron, D. Coker, Gabriel Cuellar Partida, Devika Dhamija, Sayantan Das, S. Elson, Teresa Filshtein, K. Fletez-Brant, P. Fontanillas, Will Freyman, P. Gandhi, B. Hicks, D. Hinds, K. Huber, E. Jewett, Yunxuan Jiang, A. Kleinman, Katelyn Kukar, Vanessa Lane, Keng-Han Lin, Maya Lowe, Marie K. Luff, J. McCreight, M. Mcintyre, K. McManus, Steven J. Micheletti, M. Moreno, J. Mountain, S. Mozaffari, P. Nandakumar, E. Noblin, Jared O’Connell, A. Petrakovitz, G. D. Poznik, Morgan Schumacher, Anjali J. Shastri, J. Shelton, Jingchunzi Shi, S. Shringarpure, C. Tian, Vinh Tran, J. Tung, Xin Wang, W. Wang, C. Weldon, Peter Wilton, J. Sealock, L. Davis, N. Pedersen, C. Reynolds, I. Karlsson, S. Magnússon, H. Stefánsson, Steinunn Thordardottir, P. Jonsson, J. Snaedal, A. Zettergren, I. Skoog, S. Kern, M. Waern, H. Zetterberg, K. Blennow, E. Stordal, K. Hveem, J. Zwart, L. Athanasiu, P. Selnes, I. Saltvedt, S. Sando, I. Ulstein, S. Djurovic, T. Fladby, D. Aarsland, G. Selbæk, S. Ripke, K. Stefánsson, O. Andreassen, D. Posthuma +114 moresemanticscholar +1 more sourceMulti‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica +10 morewiley +1 more sourceSupplementary Table 1 and Figures 1 - 6 from Genome-Wide Association Study of Prognosis in Advanced Non–Small Cell Lung Cancer Patients Receiving Platinum-Based Chemotherapy
, 2023 Lingmin Hu, Chen Wu, Xueying Zhao, Rebecca S. Heist, Su Li, Yang Zhao, Baohui Han, Songyu Cao, Minjie Chu, Juncheng Dai, Jing Dong, Yongqian Shu, Lin Xu, Yijiang Chen, Yi Wang, Feng Lu, Yue Jiang, Dianke Yu, Hongyan Chen, Wen Tan, Hongxia Ma, Jiaping Chen, Guangfu Jin, Tangchun Wu, Daru Lu, David C. Christiani, Dongxin Lin, Zhibin Hu, Hongbing Shen +28 moreopenalex +1 more sourceChemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam +14 morewiley +1 more sourceTonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes +17 morewiley +1 more sourceExpression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger +5 morewiley +1 more sourceDetecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda +12 morewiley +1 more sourceGenome-wide association study reveals new loci for yield-related traits in Sichuan wheat germplasm under stripe rust stress [PDF]
, 2019 Xueling Ye, Jian Li, Yukun Cheng, Fangjie Yao, Li Long, Yuqi Wang, Yu Wu, Jing Li, Jirui Wang, Qiantao Jiang, Houyang Kang, Wei Li, Pengfei Qi, Xiujin Lan, Jian Ma, Yaxi Liu, Yunfeng Jiang, Yuming Wei, Xianming Chen, Chunji Liu, Youliang Zheng, Guoyue Chen +21 moreopenalex +1 more sourceData‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo +8 morewiley +1 more source
