Results 121 to 130 of about 3,155,630 (345)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Additional file 10 of Identification of sex determination locus in sea cucumber Apostichopus japonicus using genome-wide association study

, 2022
Yixin Wang, Yujia Yang, Yulong Li, Muyan Chen   +3 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Genome-wide association studies for methane emission and ruminal volatile fatty acids using Holstein cattle sequence data [PDF]

, 2020
Ali Jalil Sarghale, M. Moradi Shahrebabak, Hossein Moradi Shahrebabak, A Nejati Javaremi, Mahdi Saatchi, Majid Khansefid, Younes Miar   +6 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Nature Genetics, 2021
D. Wightman, I. Jansen, J. Savage, A. Shadrin, S. Bahrami, D. Holland, A. Rongve, S. Børte, B. Winsvold, O. K. Drange, Amy E. Martinsen, A. Skogholt, C. Willer, G. Bråthen, Ingunn Bosnes, J. Nielsen, L. Fritsche, Laurent F. Thomas, L. Pedersen, M. Gabrielsen, M. B. Johnsen, T. W. Meisingset, Wei Zhou, P. Proitsi, A. Hodges, Richard J. B. Dobson, L. Velayudhan, K. Heilbron, A. Auton, Michelle Stella Elizabeth Robert K. Jessica Katarzyna Emily Agee Aslibekyan Babalola Bell Bielenberg Bryc Bull, M. Agee, S. Aslibekyan, Elizabeth Babalola, R. Bell, Jessica Bielenberg, K. Bryc, Emily Bullis, Briana Cameron, D. Coker, Gabriel Cuellar Partida, Devika Dhamija, Sayantan Das, S. Elson, Teresa Filshtein, K. Fletez-Brant, P. Fontanillas, Will Freyman, P. Gandhi, B. Hicks, D. Hinds, K. Huber, E. Jewett, Yunxuan Jiang, A. Kleinman, Katelyn Kukar, Vanessa Lane, Keng-Han Lin, Maya Lowe, Marie K. Luff, J. McCreight, M. Mcintyre, K. McManus, Steven J. Micheletti, M. Moreno, J. Mountain, S. Mozaffari, P. Nandakumar, E. Noblin, Jared O’Connell, A. Petrakovitz, G. D. Poznik, Morgan Schumacher, Anjali J. Shastri, J. Shelton, Jingchunzi Shi, S. Shringarpure, C. Tian, Vinh Tran, J. Tung, Xin Wang, W. Wang, C. Weldon, Peter Wilton, J. Sealock, L. Davis, N. Pedersen, C. Reynolds, I. Karlsson, S. Magnússon, H. Stefánsson, Steinunn Thordardottir, P. Jonsson, J. Snaedal, A. Zettergren, I. Skoog, S. Kern, M. Waern, H. Zetterberg, K. Blennow, E. Stordal, K. Hveem, J. Zwart, L. Athanasiu, P. Selnes, I. Saltvedt, S. Sando, I. Ulstein, S. Djurovic, T. Fladby, D. Aarsland, G. Selbæk, S. Ripke, K. Stefánsson, O. Andreassen, D. Posthuma   +114 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source