Results 131 to 140 of about 42,684,660 (287)

Genome-wide association study (GWAS) datasets used in the study.

Genome-wide association study (GWAS) datasets used in the study.
Zhekang Liu (17941199), Xinwang Duan (4595974), Yijia Shao (4578811)   +2 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.

, 2011
BACKGROUND: Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered.
Gibson, Lorna J, Lorna J. Gibson, Ross, Gillian, Peto, Julian, Gemma Simpson, Johnson, Nichola, Fletcher, Olivia, Coupland, Ben, Minouk Schoemaker, Chanock, Stephen J., Williamson, Jill, Schoemaker, Minouk, Fay J. Hosking, Simpson, Gemma, Palles, Claire, Jill Williamson, Kevin B. Jacobs, Jacobs, Kevin B, Katarzyna Tomczyk, Gillian Ross, Alan Ashworth, Swerdlow, Anthony, Jones, Michael, Dos-Santos-Silva, Isabel, Stephen J. Chanock, Lathrop, Mark, Simon Heath, Sarah Chilcott-Burns, Isabel dos Santos Silva, Walker, Kate, dos Santos Silva, Isabel, Houlston, Richard S, Zelenika, Diana, Mark Lathrop, Nichola Johnson, Ben Coupland, David J. Hunter, Claire Palles, Ashworth, Alan, Kate Walker, Tomczyk, Katarzyna, Tomlinson, Ian P, Orr, Nick; id_orcid, Nick Orr, Peter Broderick, Orr, Nick, Swerdlow, Anthony J, Ivo Gut, Michael Jones, Diana Zelenika, Ian P. Tomlinson, Gut, Ivo, Chanock, Stephen J, Broderick, Peter, Chilcott-Burns, Sarah, Olivia Fletcher, Anthony Swerdlow, Walker-Springett, Kate, Richard S. Houlston, Hosking, Fay J, Heath, Simon, Julian Peto, Hunter, David J   +62 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Genetic risk loci for Parkinson's disease and dementia in a large-scale population-based Taiwanese cohort (TPMI)Research in context

The Lancet Regional Health. Western Pacific
Summary: Background: The genetic architecture of Parkinson's disease (PD) and progression to PD dementia (PDD) remains incompletely characterized in Asians.
Chin-Hsien Lin, Chien-Ching Chang, Hung-Hsin Chen, Wan-Jia Lin, Chia-Lang Hsu, Rung-Juen Lin, Yi-Jen Guo, Ting-Chun Fang, Shinn-Zong Lin, Chih-Yang Huang, Shuu-Jiun Wang, Jen-Fan Hang, Sun-Wung Hsieh, Mei-Chuan Chou, Tu-Hsueh Yeh, Chaur-Jong Hu, Fu-Chi Yang, Hsin-An Chang, Tsong-Hai Lee, Meng-Han Tsai, Ming-Che Kuo, Jyh-Ming Liou, Ming-Shiang Wu, Kye Won Park, Sun Ju Chung, Eng-King Tan, Cathy Shen-Jang Fann   +26 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The genetic aspects of multiple sclerosis

Annals of Indian Academy of Neurology, 2009
The epidemiology of multiple sclerosis has been extensively investigated and two features have consistently emerged: marked geographical variation in prevalence and substantial familial clustering. At first sight, geographic variation would seem to imply
Sawcer Stephen
doaj