Results 121 to 130 of about 42,684,660 (287)
Comprehensive Evidence for Mortality and Underlying Morbidity Related to Visceral Fat Distribution
Med ResearchLinking obesity to mortality is an intriguing and controversial topic. This study tried to comprehensively assess 8 adiposity surrogates and mortality association among middle‐to‐old‐aged adults to identify a superior one, and explore explanatory ...Haolong Zhou, Danyang Ling, Qin Huang, Jiaojun Liang, Guanhua Su, Zhangbo Cui, Ziwei Chen, Xiaowen Ma, Zhou Jiang, Shuo Zheng, Haodong Tian, Qi Wang +11 moredoaj +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more sourceUSP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 morewiley +1 more sourceTargeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array [PDF]
, 2009 The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans.Döring, Angela, Illig, T, Peeter Juhanson, Katrin Kepp, Juhanson, P., Juhanson, P, Samani, Nilesh, Philip Howard, Caulfield, Mark J., P. B. Munroe (7602386), Veldre, G, Farrall, Martin, Lichtner Peter, Dobson, RJ, Viigimaa, M., C. Gieger (7609259), Morris Brown, Putku Margus, Wichmann, H.-E., Illig, T., Siim Sõber, Gudrun Veldre, Shaw-Hawkins, Sue, Kelgo, Piret, Illig Thomas, R. J. Dobson (7602557), Samani, N, Samani Nilesh, Laan, Maris, HYPertens ESTonia Study, A. Dominiczak (7611551), Munroe, Patricia B., Kepp, K, John Connell, T. Illig (7609322), Samani, N., M. Putku (7602647), Viigimaa Margus, Farrall Martin, Brown, M, Peter Lichtner, Sober, S, A. Döring (7609562), Lichtner, Peter, P. Howard (7611350), Piret Kelgo, Juhanson Peeter, Dobson, Richard J.; id_orcid, Org, E, Farrall, M, Dobson, R.J., Meitinger, T, Veldre, Gudrun, E. Org (7602644), Kooperative Gesundheitsforschung in der Region Augsburg Study, Lichtner, P., H-Erich Wichmann, Martin Farrall, Kepp, Katrin, Gieger, Christian, HYPertension in ESTonia Study, Margus Putku, Newhouse, SJ, Onipinla Abiodun, Caulfield Mark J., Meitinger, T., M. Laan (7602659), Caulfield, MJ, Maris Laan, Eyheramendy, S., Onipinla, A., Newhouse, S.J., M. Viigimaa (7602620), Gieger, C, Dominiczak, A., Kelgo, P, Onipinla, A, Döring Angela, Newhouse, Stephen J.; id_orcid, Shaw-Hawkins Sue, Susana Eyheramendy, Munroe, PB, Klopp, Norman, Newhouse, Stephen J., Brown, Morris, Putku, Margus, M. Farrall (6522599), Wichmann, H.-Erich, Meitinger Thomas, S. Eyheramendy (7611197), Wichmann, Heinz-Erich, Putku, M, M. Brown (3020991), Gieger, C., Christian Gieger, Döring, A., Dobson, Richard J., Munroe, P.B., Juhanson, Peeter, Lichtner, P, Richard J Dobson, Org, E., H-E. Wichmann (7611602), Doering, Angela, Howard Philip, Kepp, K., Org, Elin, Kelgo Piret, Anna Dominiczak, Klopp, N., S. Shaw-Hawkins (7602380), Org Elin, Gieger Christian, Dominiczak Anna, Margus Viigimaa, Viigimaa, Margus, Newhouse Stephen J., K. Kepp (7611593), Sue Shaw-Hawkins, Stephen J Newhouse, Howard, P., Munroe Patricia B., Wichmann, H. Erich, P. Kelgo (7611596), Wichmann H.-Erich, Eyheramendy, S, Kooperative Gesundheitsforsch, Putku, M., M. J. Caulfield (7602383), Patricia B Munroe, Howard, P, Angela Döring, Eyheramendy, Susana, Nilesh Samani, Veldre Gudrun, Kepp Katrin, Sõber Siim, J. . Connell (7611608), Wichmann, HE, MRC British Genet Hypertens Study, Laan, M., Laan Maris, Elin Org, Connell, J, Illig, Thomas, Meitinger, Thomas, Doring, A, Viigimaa, M, Thomas Illig, N. Klopp (7611599), S. J. Newhouse (7602371), Connell John, S. Sõber (7602650), Shaw-Hawkins, S, Onipinla, Abiodun, Shaw-Hawkins, S., Dobson Richard J., Dominiczak, A, Klopp Norman, T. Meitinger (14191), Abiodun Onipinla, G. Veldre (7602656), Sõber, Siim, Thomas Meitinger, Eyheramendy Susana, P. Lichtner (7611605), A. Onipinla (7602377), Mark J Caulfield, Klopp, N, Caulfield, M.J., N. Samani (7611611), P. Juhanson (7602641), Dominiczak, Anna, Veldre, G., Connell, J., Connell, John, Norman Klopp, MRC British Genetics of Hypertension Study, Brown, M., Sõber, S., Howard, Philip, Brown Morris, Laan, M, Sõber, S;Org, E;Kepp, K;Juhanson, P;Eyheramendy, S;Gieger, C;Lichtner, P;Klopp, N;Veldre, G;Viigimaa, M;Döring, A;Putku, M;Kelgo, P;Shaw-Hawkins, S;Howard, P;Onipinla, A;Dobson, RJ;Newhouse, SJ;Brown, M;Dominiczak, A;Connell, J;Samani, N;Farrall, M;Caulfield, MJ;Munroe, PB;Illig, T;Wichmann, HE;Meitinger, T;Laan, M +183 morecore +1 more sourceFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more sourceGenome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension [PDF]
, 2010 Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%–2% of the population variation in BP and hypertension.Zanchetti A, Wichmann HE, Samani, NJ, Munroe, P., Navis G, P. Sever (7602536), Hastie, Claire E., A. H. Baker (7611224), Martina Montagnana, McDonald, Robert A., Wahlstrand, B, Kathiresan, S., Snieder, Harold; id_orcid, Völzke Henry, Ruth J. F. Loos, Nicklin, SA, Morris Brown, Nolte IM, Wichmann, H.-E., Kathiresan S, Padmanabhan Sandosh, Zhang Feng, M. Montagnana (7611173), Caulfield MJ, Rettig Rainer, Laan, Maris, Rettig, Rainer, J. Luan (7609367), Mc Donald, R.A., Melander, Olle,, Peter Vollenweider, Sever, P, Nicklin Suart, A., Zanchetti, A., Hedblad, Bo, Ole Torffvit, A. Teumer (7609454), Stewart Laing, Hastie, CE, P. Welsh (7611230), M. Burnier (7611161), Bochud, Murielle, Miller, WH, Wichmann, H.E., Martin Farrall, Montagnana M, Caulfield Mark J., M. C. Monti (7611146), J. P. Pell (6240134), Michel Burnier, Eyheramendy, S., Maris Laan, David P Strachan, Snieder Harold, Connell JMC, Vollenweider Peter, Connell, JMC, Signorini S, Zhang, F, Newton-Cheh Christopher, Laing, Stewart, M. Farrall (6522599), Stanton Alice, Timothy D Spector, Mark J. Caulfield, Sattar, N, B. Corso (7611152), Gentilini D, Kwakernaak, A.J., McDonald RA, Penninx Brenda W., W. H. Miller (7611218), Spector Timothy, D., Conell, J.M.C., Fava, Cristiano,, Shields, D.C., Kjeldsen, S, Samani Nilesh, J., Strachan, David P., Corso, B., Timothy D. Spector, Montagnana Martina, Pell JP, Nicklin Stuart A., D. S. Siscovick (7611209), Welsh, P., Johnson, T, Connell, John M. C., Johnson, T., Naveed Sattar, Sjögren, M, Bochud Murielle, Torffvit, O, Sever Peter, Kjeldsen Sverre, G. Grassi (2592760), Navis, G., Laan, M., Padmanabhan S, Johnson T, S. Laing (7611149), Nolte Ilja, M., C. Delles (7602479), Jill P. Pell, Miller William H., Shields Denis, Colm, Lucas, Gavin, Dominiczak A.F., Connell John M. C., Snieder, H, Mark J Caulfield, Snieder H, Caulfield, M.J., A. J. Kwakernaak (3694963), Newton Cheh C, Stuart A. Nicklin, Connell John, M.C., Wahlstrand, Björn, Hedblad, Bo,, Newton-Cheh C, Brown, M., Laing S, Montagnana, Martina,, Brown Morris, Hedner, Thomas, Wareham, N.J., A. M. Di Blasio (7611140), Graham, D, Miller, W.H., Nicholas J Wareham, Rettig R, David S Siscovick, Nicholas J. Wareham, Nolte, Ilja M., F. Zhang (2167666), David S. Siscovick, Loos, Ruth J. F., McDonald Robert, A., Burnier, M, G. Mancia (7611191), Nolte Ilja M., Arora, Pankaj, Murielle Bochud, Cristina Menni, Loos, RJF, Cesana Giancarlo, Sjögren, Marketa, Baker, Andrew H., Nolte, Ilja M.; id_orcid, Welsh P, Lund University., van der Harst, Pim, Welsh, P, Monti Maria Cristina, Völzke, H, Bochud M, Sever, Peter, Baker, AH, Hedner Thomas, van der Harst, Pim; id_orcid, Maillard, Marc, Torffvit, O., Stanton, A, Wareham NJ, Kjeldsen, Sverre, Wahlstrand B, Lee, WK, B. Hedblad (7611182), S. Kathiresan (7606013), Brenda W Penninx, Spector Timothy D., Lee, W.K., Teumer, A., Toby Johnson, McBride, M, Menni Cristina, Fava Cristiano, Pim van der Harst, Penninx, Brenda W., Susana Eyheramendy, Wareham, NJ, Connell, John M.C., Teumer, A, Barbara Corso, Melander, O, Wareham Nicholas, J., Penninx, B.W., Ruth J F Loos, Claire E Hastie, Shields, Denis Colm, Alberto Zanchetti, Peter Sever, Lee Wai K., Torffvit Ole, Delles, C, Luan, J., Cristiano Fava, McBride Martin, Mancia, G., Gavin Lucas, Shields DC, Luan, Jian'an, Zhang, Feng, Arora Pankaj, Björn Wahlstrand, John M C Connell, Newton-Cheh, C, Wareham, Nicholas J., Cesana, Giancarlo, Snieder, Harold, Melander Olle, Eyheramendy, Susana, Di Blasio, A.M., Torffvit, Ole, McBride, Martin, Maillard Marc, Corso B, Schork, Nicholas J., van der Harst Pim, Nolte, IM, T. Johnson (7602368), Teumer Alexander, D. Graham (29758), Loos Ruth, J.F., Monti Maria, Cristina, Hastie Claire E., S. A. Nicklin (7611221), M. Bochud (7611158), Kwakernaak Arjan, J., Global BPgen Consortium (7611233), Sjögren M, Voelzke, Henry, Vollenweider, P, Delles, Christian, Monti, M.C., Stanton, A., Grassi, G, Grassi, G., van der Harst P, Strachan, DP, Eyheramendy Susana, Soranzo Nicole, Danese Elisa, Gentilini, D, Fava, C, Hedner, T, Spector, TD, Navis, G, B. W. Penninx (7611212), Luan, JA, Connell JM, M. Maillard (3464312), Delles Christian, Luan, Jian'an, Montagnana, Martina, Pell, JP, Hastie CE, Eyheramendy S, Robert A. McDonald, Menni C, Luan J, Anna F Dominiczak, Connell, JM, Caulfield, Mark J., Di Blasio, AM, Burnier, M., Monti, MC, Siscovick David, S., Kwakernaak, Arjan J., Signorini, Stefano, Henry Völzke, Stuart A Nicklin, van der Harst, P, Loos RJ, Hedblad B, Strachan David P., Nolte, I.M., Pell Jill P., Burnier, Michel, Munroe P, W. K. Lee (7602476), H Erich Wichmann, null null, Ilja M. Nolte, Giuseppe Mancia, Monti, Maria Cristina, Menni, C, Farrall Martin, Brown, M, Montagnana, M., Samani, Nilesh J., Nilesh J. Samani (7579793), S. Signorini (7611194), McDonald, R.A., Farrall, M, Anna Maria Di Blasio, T. D. Spector (7608968), Baker Andrew H., Sever P, Loos RJF, Penninx Brenda, W., Vollenweider, P., Marc Maillard, Sattar Naveed, Wahlstrand Björn, John M. C. Connell, Newton-Cheh, Christopher, Kwakernaak AJ, Soranzo, N, Bochud, M., M. Laan (7602659), Fava C, Penninx, BW, Sattar, Naveed, Kjeldsen S, Snieder, H., Martin McBride, Graham Delyth, Vollenweider P, G. Cesana (7611188), Mancia G, Brenda W. Penninx, O. Torffvit (7611179), D. P. Strachan (3809152), Newton-Cheh, C., A. Stanton (7611200), R. J. Loos (7608845), McDonald, RA, Danese, E., David P. Strachan, Nicklin SA, William H. Miller, Siscovick, DS, M. Sjögren (7611167), Pell, Jill P., Arora P, C. E. Hastie (7602473), H. Snieder (7611185), Signorini, S, McDonald Robert A., Ilja M Nolte, Dominiczak Anna, F., Miller, William H., Cesana, G, Stefano Signorini, Guido Grassi, I. M. Nolte (3809176), Samani, N.J., Wichmann H. Erich,, D. Gentilini (4402804), Kathiresan, S, Gerjan Navis, Harold Snieder, Samani NJ, Rettig, R, Feng Zhang, Baker, A.H., Siscovick David S., P. van der Harst (7594607), Pell Jill, P., Burnier Michel, Soranzo, N., Dominiczak, A.F., Mancia Giuseppe, Padmanabhan, Sandosh, Torffvit O, Gentilini, Davide, Völzke, Henry, Stanton A, Di Blasio Anna, Maria, van der Harst, P., Wichmann, HE, H. Erich Wichmann, Lucas, G, Mancia, G, Zanchetti, A, Mancia, Giuseppe, M. McBride (7611215), Elisa Danese, Zhang, F., Fava, Cristiano, Denis Colm Shields, Feng, Zhang, Menni, C., Laing, S., Global BPgen Consortium, Andrew H Baker, Thomas Hedner, P. Munroe (7609094), Spector, Timothy D., C. Newton-Cheh (7602563), Lee WK, Munroe, Patricia, Delyth Graham, Torffvit, Ole,, Delles, C., Hedblad, B, Sverre Kjeldsen, Wahlstrand, B., Robert A McDonald, Sjögren Marketa, Grassi G, N. Sattar (7608890), Farrall, M., O. Melander (7602683), Teumer, Alexander, Olle Melander, Dominiczak, Anna F., Kwakernaak Arjan J., Di Blasio Anna Maria, Navis Gerjan, D. C. Shields (7602542), Laan, M, Kwakernaak A, Laing Stewart, Zanchetti Alberto, Zhang F, Cesana, G., G. Navis (7611155), Siscovick, David S., C. Fava (7611170), Pell, J.P., Munroe Patricia, Siscovick DS, Melander O, Jill P Pell, Nilesh J. Samani, Strachan, D.P., Corso Barbara, Fava, C., Lucas Gavin, Maillard, M, Lucas G, N. Soranzo (7608857), Baker Andrew, H., Hastie, C.E., Sever, P., Farrall, Martin, Laan M, Hedner, T., Davide Gentilini, Corso, B, Samani Nilesh J., S. Padmanabhan (637530), Giancarlo Cesana, Stanton, Alice, Shields Denis Colm, William H Miller, Graham, Delyth, Völzke H, Sekar Kathiresan, Hedblad Bo, Danese, Elisa, Bo Hedblad, Maillard M, Miller William, H., Melander, O., Montagnana, M, Vollenweider, Peter, Burnier M, T. Hedner (7602677), Wareham Nicholas J., Wai K Lee, A. Zanchetti (7611236), Soranzo, Nicole, P. Arora (7611206), Völzke, H., Andrew H. Baker, Connell, J.M.C., Johnson, Toby, Miller WH, Strachan David, P., Sattar, N., C. Menni (7611143), B. Wahlstrand (7602680), Di Blasio AM, Sattar N, Rettig, R., Signorini Stefano, Christian Delles, Arjan J Kwakernaak, Luan Jian'an, Siscovick, D.S., Harst, Pim van der, H. Völzke (6643736), Marketa Sjögren, Danese, E, Hastie Claire, E., Monti MC, Penninx BW, Lee Wai, K., Caulfield, MJ, Christopher Newton-Cheh, Harst, P. van der, Dominiczak, AF, Arjan J. Kwakernaak, Caulfield Mark, J., Nicole Soranzo, J. M. Connell (7602551), Johnson Toby, Gentilini, D., Loos, RJ, Rainer Rettig, Anna F. Dominiczak, Loos Ruth J. F., G. Lucas (7606529), Padmanabhan, S, Teumer A, Brown, Morris, Bochud, M, Dominiczak Anna F., S. Eyheramendy (7611197), Wichmann, Heinz-Erich, Grassi, Guido, Hedblad, B., Alexander Teumer, Hedner T, Munroe, P, Wai K. Lee, Luan, J, M. Brown (3020991), Luan JA, Danese E, Welsh, Paul, Laing, S, Welsh Paul, Spector TD, Pankaj Arora, Patricia Munroe, Newton Cheh, Christopher, Maria Cristina Monti, Melander, Olle, Delles C, Graham D, H. E. Wichmann (7608932), Padmanabhan, S., R. A. McDonald (7611227), A. F. Dominiczak (7602482), Spector, T.D., Kwakernaak, AJ, Baker AH, Loos, R.J.F., Zanchetti, Alberto, Navis, Gerjan, Sjögren, Marketa,, Graham, D., Wichmann, H. Erich, Claire E. Hastie, Farrall M, N. J. Wareham (7608962), Eyheramendy, S, Kathiresan, Sekar, M. J. Caulfield (7602383), Nicklin, S.A., P. Vollenweider (4002164), Gentilini Davide, S. Kjeldsen (7611164), Arora, P, E. Danese (7611176), Sjögren, M., Laan Maris, Nicklin, Stuart A., Menni, Cristina, Signorini, S., Gentilini, G., Arora, P., Alice Stanton, Dominiczak AF, R. Rettig (7611203), Kathiresan Sekar, Paul Welsh, Maillard, M., Soranzo N, Corso, Barbara, Cesana G, Sandosh Padmanabhan, Di Blasio, Anna Maria, Jian'an Luan, Grassi Guido, McBride, M., Strachan DP, Shields, DC, Wichmann H. Erich, Lee, Wai K., Nilesh J Samani, Brown M, Lucas, G., Luan, J.A., McBride M, Kjeldsen, S., Bjo rn Wahlstrand, Christopher NewtonCheh, Marketa Sjo gren, Henry Vo lzke, Blasio, A.M. di +594 morecore +1 more sourceMITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson +13 morewiley +1 more sourceOncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan +13 morewiley +1 more sourceLoss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann +11 morewiley +1 more sourcePAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann +10 morewiley +1 more source