Results 171 to 180 of about 3,091,688 (344)
Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis +11 morewiley +1 more sourceAssessing the Causal Impact of Social Isolation on Angina Risk: Evidence from a Two-Sample Mendelian Randomization Study
Journal of Multidisciplinary HealthcareShenghua Yan,1,* Feifei Gu,2,* Bei Tian1,2 1Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai, 201203, People’s Republic of China; 2Department of Nursing, Shanghai Pudong New Area Zhoupu Hospital (Shanghai Health Medical ...Yan S, Gu F, Tian Bdoaj Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level
Molecular Oncology, EarlyView.In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz +14 morewiley +1 more sourceAdditional file 1: of Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans
, 2019 Meijian Guan, Jacob M. Keaton, Latchezar Dimitrov, Andrew A. Hicks, Jianzhao Xu, Li‐Jun Ma, Swapan K. Das, Yii-Der Chen, Josef Coresh, Myriam Fornage, Nora Franceschini, Holly Kramer, Carl D. Langefeld, Josyf C. Mychaleckyj, Rulan S. Parekh, Wendy S. Post, Laura J. Rasmussen‐Torvik, Stephen S. Rich, Jerome I. Rotter, John R. Sedor, Denyse Thornley‐Brown, Adrienne Tin, James Wilson, Barry I. Freedman, Donald W. Bowden, Maggie C. Y. Ng +25 moreopenalex +1 more sourceGenome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
Nature Genetics, 2009 J. Lambert, S. Heath, G. Even, D. Campion, K. Sleegers, M. Hiltunen, O. Combarros, D. Zélénika, M. Bullido, B. Tavernier, L. Letenneur, K. Bettens, C. Berr, F. Pasquier, N. Fievet, P. Barberger‐Gateau, S. Engelborghs, P. Deyn, I. Mateo, A. Franck, S. Helisalmi, E. Porcellini, O. Hanon, M. Pancorbo, C. Lendon, C. Dufouil, C. Jaillard, T. Léveillard, V. Álvarez, P. Bosco, M. Mancuso, F. Panza, B. Nacmias, P. Bossù, P. Piccardi, G. Annoni, D. Seripa, D. Galimberti, D. Hannequin, F. Licastro, H. Soininen, K. Ritchie, H. Blanché, J. Dartigues, C. Tzourio, I. Gut, C. Broeckhoven, A. Alpérovitch, M. Lathrop, P. Amouyel +49 moresemanticscholar +1 more sourceAggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera +11 morewiley +1 more sourceLifecourse Genome-Wide Association Study Meta-Analysis Refines Understanding of the Critical Life Stages for the Influence of Adiposity on Breast Cancer Risk [PDF]
Grace M. Power, Laxmi Bhatta, Amanda Hughes, Carolina Medina‐Gómez, Anne Richmond, Genevieve M Leyden, Bethan Lloyd‐Lewis, Eleanor Sanderson, Rebecca C. Richmond, Elizabeth C. Corfield, Daniel L. McCartney, Carlton Haywood, Irene Fontes Marques, Fernando Rivadeneira, Bjørn Olav Åsvold, Gibran Hemani, Janine F. Felix, Ben Brumpton, Alexandra Havdahl, George Davey Smith +19 moreopenalex +1 more sourceTumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini +12 morewiley +1 more source
