Results 191 to 200 of about 3,155,630 (345)
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter +2 morewiley +1 more sourceA Genome-Wide Association Study Reveals Desmoglein-2 Predominance in Japanese Arrhythmogenic Cardiomyopathy. [PDF]
J ArrhythmIshikawa T, Sonehara K, Sonoda K, Hayashi K, Kato K, Nagase S, Kusano K, Aiba T, Horie M, Ohno S, Okada Y, Makita N. +11 moreeuropepmc +1 more sourceGenome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Nature Genetics, 2019 Hunna J. Watson, Z. Yilmaz, L. Thornton, Christopher Hübel, J. Coleman, Héléna A. Gaspar, J. Bryois, A. Hinney, V. Leppä, M. Mattheisen, S. Medland, S. Ripke, Shuyang Yao, P. Giusti-Rodríguez, K. Hanscombe, K. Purves, R. Adan, L. Alfredsson, T. Ando, O. Andreassen, J. Baker, W. Berrettini, Ilka Boehm, C. Boni, V. B. Perica, Katharina Buehren, R. Burghardt, M. Cassina, S. Cichon, M. Clementi, R. Cone, P. Courtet, S. Crow, J. Crowley, U. Danner, O. Davis, M. Zwaan, G. Dedoussis, D. Degortes, J. DeSocio, D. Dick, D. Dikeos, C. Dina, M. Dmitrzak-Węglarz, E. Docampo, L. Duncan, K. Egberts, S. Ehrlich, G. Escaramís, T. Esko, X. Estivill, A. Farmer, A. Favaro, F. Fernández-Aranda, M. Fichter, K. Fischer, M. Föcker, L. Foretova, A. Forstner, M. Forzan, C. Franklin, S. Gallinger, I. Giegling, J. Giuranna, F. Gonidakis, P. Gorwood, Monica Gratacos Mayora, S. Guillaume, Yiran Guo, H. Hakonarson, K. Hatzikotoulas, J. Hauser, J. Hebebrand, S. Helder, S. Herms, B. Herpertz-Dahlmann, W. Herzog, L. Huckins, J. Hudson, H. Imgart, H. Inoko, V. Janout, S. Jiménez-Murcia, A. Julià, G. Kalsi, D. Kaminská, J. Kaprio, L. Karhunen, A. Karwautz, M. Kas, J. Kennedy, A. Keski-Rahkonen, K. Kiezebrink, Youl-Ri Kim, L. Klareskog, K. Klump, G. Knudsen, M. C. Via, S. Hellard, R. Levitan, Dong Li, L. Lilenfeld, Bochao D. Lin, J. Lissowska, J. Luykx, P. Magistretti, M. Maj, Katrin Mannik, S. Marsal, C. Marshall, M. Mattingsdal, S. McDevitt, P. McGuffin, A. Metspalu, I. Meulenbelt, N. Micali, K. Mitchell, A. Monteleone, P. Monteleone, Melissa A. Munn-Chernoff, B. Nacmias, M. Navratilova, I. Ntalla, J. O'toole, R. Ophoff, L. Padyukov, A. Palotie, J. Pantel, H. Papežová, D. Pinto, R. Rabionet, Anu Raevuori, N. Ramoz, T. Reichborn-Kjennerud, V. Ricca, S. Ripatti, Franziska Ritschel, Marion E. Roberts, A. Rotondo, D. Rujescu, F. Rybakowski, P. Santonastaso, A. Scherag, S. Scherer, U. Schmidt, N. Schork, A. Schosser, J. Seitz, L. Šlachtová, P. Slagboom, M. S. '. Slof-Op 't Landt, A. Słopień, S. Sorbi, B. Świątkowska, J. Szatkiewicz, I. Tachmazidou, E. Tenconi, A. Tortorella, F. Tozzi, J. Treasure, A. Tsitsika, M. Tyszkiewicz-Nwafor, K. Tziouvas, A. Elburg, E. F. Furth, G. Wagner, E. Walton, E. Widén, E. Zeggini, S. Zerwas, S. Zipfel, A. Bergen, J. Boden, H. Brandt, Steven Crawford, K. Halmi, L. Horwood, Craig Johnson, A. Kaplan, W. Kaye, James E Mitchell, C. Olsen, J. Pearson, N. Pedersen, M. Strober, T. Werge, D. Whiteman, D. Woodside, G. Stuber, S. Gordon, J. Grove, A. Henders, A. Juréus, K. Kirk, J. Larsen, Richard Parker, L. Petersen, J. Jordan, M. Kennedy, G. Montgomery, T. Wade, A. Birgegård, P. Lichtenstein, C. Norring, M. Landén, N. Martin, P. Mortensen, P. Sullivan, G. Breen, C. Bulik, Anorexia Nervosa Genetics Initiative, Eating Disorder Working Group of the Psychiatric Genomics Consortium +211 moresemanticscholar +1 more sourceCorrelation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova +10 morewiley +1 more sourceA pilot genome-wide association study of collagen deposition in collagenous colitis. [PDF]
Gastroenterol Rep (Oxf)Di Lorenzo B, Zheng T, Rieder F, Colombel JF, Peter I, Kupcinskas J, Ohlsson B, Ferrer Cassado C, Zabana Y, Münch A, Jančiauskas D, Gordon IO, D'Amato M, Roda G. +13 moreeuropepmc +1 more sourceBasroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim +4 morewiley +1 more sourceGenome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci
Joanne B. Cole, Emma H. Dahlström, Damian Fermin, Yogesh Gupta, Claire Hill, Laura J. Smyth, Hongbo Liu, Raymond J. Kreienkamp, Marcus G. Pezzolesi, Jingjing Cao, Erkka Valo, Wei‐Min Chen, Suna Önengüt-Gümüşcü, Stephen S. Rich, Eoin Brennan, Darrell Andrews, Ciarán Kennedy, Harvest F. Gu, Lars Stechemesser, Raimund Weitgasser, Jeļizaveta Sokolovska, Lina Radzevičienė, Rasa Verkauskienė, Nicolae Mircea Panduru, Peter Rossing, Tarunveer S. Ahluwalia, Gianpaolo Zerbini, Michel Marre, Samy Hadjadj, Tina Costacou, Rachel G. Miller, Ronald Klein, Kristine E. Lee, Janet K. Snell‐Bergeon, Maria Luiza Caramori, Michael Mauer, Kerstin Brismar, Petter Bjornstad, Amy Jayne McKnight, Gareth J. McKay, Viji Nair, Rany M. Salem, Per‐Henrik Groop, Catherine Godson, Katalin Suszták, Matthias Kretzler, Alexander P. Maxwell, Andrzej S. Królewski, Andrew D. Paterson, Niina Sandholm, José C. Florez, Joel N. Hirschhorn +51 moreopenalex +2 more sourcesGenetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova +25 morewiley +1 more source
