Results 71 to 80 of about 3,155,630 (345)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. [PDF]

, 2019
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Bagchi, Aranya, Barnes, Hanna J, Bloch, Donald B, Bowden, Donald W, Budoff, Matthew, Buswell, Mary D, Buys, Emmanuel S, Campbell, Catherine Y, Criqui, Michael H, Debette, Stephanie, Erbel, Raimund, Feitosa, Mary F, Franceschini, Nora, Freedman, Barry I, Gudnason, Vilmundur, Guo, Xiuqing, Harris, Tamara, Hoffmann, Udo, Hwang, Shih-Jen, Johnson, Andrew D, Jöckel, Karl-Heinz, Kälsch, Hagen, Lindsay, Mark E, Lino Cardenas, Christian L, Lu, Lingyi, Malhotra, Rajeev, Mauer, Andreas C, Moebus, Susanne, Nicholson, Christopher J, Nigwekar, Sagar U, Nöthen, Markus M, O'Donnell, Christopher J, Pechlivanis, Sonali, Post, Wendy S, Rhee, David K, Rotter, Jerome I, Rourke, Caitlin O', Shelton, Georgia, Sigurdsson, Sigurdur, Sigurslid, Haakon H, Slocum, Charles, Smith, Albert V, Song, Ci, Thanassoulis, George, Wang, Judy, Wong, Quenna, Wunderer, Florian, Yao, Jie, Zapol, Warren M, Zhang, Xiaoling   +49 more
core   +1 more source

Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.

JAMA psychiatry, 2020
Importance With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk variants for OUD and determine genetic correlations and causal association ...
Hang Zhou, C. Rentsch, Zhongshan Cheng, R. Kember, Y. Nuñez, Richard Sherva, J. Tate, Cecilia Dao, Ke Xu, R. Polimanti, L. Farrer, A. Justice, H. Kranzler, J. Gelernter   +13 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. [PDF]

, 2011
BackgroundRheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA).
Alfredsson, Lars, Ding, Bo, Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study group, Klareskog, Lars, Ong, Rick TH, Padyukov, Leonid, Rönnelid, Johan, Seddighzadeh, Maria, Seielstad, Mark   +8 more
core  

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

bioRxiv, 2019
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing ...
J. Revez, Tian Lin, Zhen Qiao, Angli Xue, Y. Holtz, Zhihong Zhu, Jian Zeng, Huanwei Wang, J. Sidorenko, K. Kemper, A. Vinkhuyzen, J. Frater, D. Eyles, T. Burne, B. Mitchell, N. Martin, G. Zhu, P. Visscher, Jian Yang, N. Wray, J. Mcgrath   +20 more
semanticscholar   +1 more source

Multi-trait analysis for genome-wide association study of five psychiatric disorders

Translational Psychiatry, 2020
We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia (SCZ) ( n  = 65,967), bipolar disorder (BD) ( n  = 41,653), autism spectrum disorder (ASD) ( n  = 46,350), attention deficit hyperactivity disorder (ADHD) ( n ...
Yulu Wu, Hongbao Cao, A. Baranova, Hailiang Huang, Sheng Li, Lei Cai, Shuquan Rao, M. Dai, M. Xie, Yikai Dou, Qinjian Hao, Ling Zhu, Xiangrong Zhang, Yin Yao, Fuquan Zhang, Mingqing Xu, Qiang Wang   +16 more
semanticscholar   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors

Pharmacogenomics and Personalized Medicine, 2021
Zixiu Zhou, Sizhen Li, Qingsong Yang, Xiaodong Yang, Kuanxiao Hao, Yating Liu, Shanshan Xu Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, 211102, People’s Republic of ChinaCorrespondence: Sizhen LiNanjing Tongren ...
Zhou Z, Li S, Yang Q, Yang X, Hao K, Liu Y, Xu S   +6 more
doaj  

Genome-Wide Association Study Identifies Candidate Loci Associated with Platelet Count in Koreans [PDF]

Genomics & Informatics, 2014
Platelets are derived from the fragments that are formed from the cytoplasm of bone marrow megakaryocytes-small irregularly shaped anuclear cells. Platelets respond to vascular damage, contracts blood vessels, and attaches to the damaged region, thereby ...
Ji Hee Oh, Yun Kyoung Kim, Sanghoon Moon, Young Jin Kim, Bong-Jo Kim   +4 more
doaj   +1 more source