Results 71 to 80 of about 3,091,688 (344)

The complex genetic architecture of Alzheimer's disease: novel insights and future directions

EBioMedicine, 2023
Summary: Background: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. AD is highly heritable, with heritability estimates of ∼70% from twin studies.
Shea J. Andrews, Alan E. Renton, Brian Fulton-Howard, Anna Podlesny-Drabiniok, Edoardo Marcora, Alison M. Goate   +5 more
doaj   +1 more source

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. [PDF]

, 2019
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Bagchi, Aranya, Barnes, Hanna J, Bloch, Donald B, Bowden, Donald W, Budoff, Matthew, Buswell, Mary D, Buys, Emmanuel S, Campbell, Catherine Y, Criqui, Michael H, Debette, Stephanie, Erbel, Raimund, Feitosa, Mary F, Franceschini, Nora, Freedman, Barry I, Gudnason, Vilmundur, Guo, Xiuqing, Harris, Tamara, Hoffmann, Udo, Hwang, Shih-Jen, Johnson, Andrew D, Jöckel, Karl-Heinz, Kälsch, Hagen, Lindsay, Mark E, Lino Cardenas, Christian L, Lu, Lingyi, Malhotra, Rajeev, Mauer, Andreas C, Moebus, Susanne, Nicholson, Christopher J, Nigwekar, Sagar U, Nöthen, Markus M, O'Donnell, Christopher J, Pechlivanis, Sonali, Post, Wendy S, Rhee, David K, Rotter, Jerome I, Rourke, Caitlin O', Shelton, Georgia, Sigurdsson, Sigurdur, Sigurslid, Haakon H, Slocum, Charles, Smith, Albert V, Song, Ci, Thanassoulis, George, Wang, Judy, Wong, Quenna, Wunderer, Florian, Yao, Jie, Zapol, Warren M, Zhang, Xiaoling   +49 more
core   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Multi-trait analysis for genome-wide association study of five psychiatric disorders

Translational Psychiatry, 2020
We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia (SCZ) ( n  = 65,967), bipolar disorder (BD) ( n  = 41,653), autism spectrum disorder (ASD) ( n  = 46,350), attention deficit hyperactivity disorder (ADHD) ( n ...
Yulu Wu, Hongbao Cao, A. Baranova, Hailiang Huang, Sheng Li, Lei Cai, Shuquan Rao, M. Dai, M. Xie, Yikai Dou, Qinjian Hao, Ling Zhu, Xiangrong Zhang, Yin Yao, Fuquan Zhang, Mingqing Xu, Qiang Wang   +16 more
semanticscholar   +1 more source

Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1

FEBS Letters, EarlyView.
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji, Kosuke Shiraishi, Chuqian Wang, Hiroya Yurimoto, Yasuyoshi Sakai, Masahide Oku   +5 more
wiley   +1 more source

Genome-Wide Association Study of Bronchodilator Drug Response (BDR) in Minority Children with Asthma Provides Insights into Its Genetic Risk Factors [PDF]

, 2021
Jin Hui Joo, Angel C. Y. Mak, Shujie Xiao, Patrick Sleiman, Diane Hu, Scott Huntsman, Celeste Eng, Mengyuan Kan, Avantika R. Diwadkar, Håkon Håkonarson, L. Keoki Williams, EG Burchard, Blanca E. Himes   +12 more
openalex   +1 more source

Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Nature Communications, 2019
Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for ...
H. Dashti, Samuel E Jones, Andrew R. Wood, J. Lane, V. V. van Hees, Heming Wang, Jessica A Rhodes, Yanwei Song, K. Patel, Simon G Anderson, R. Beaumont, D. Bechtold, Jack Bowden, B. Cade, M. Garaulet, S. Kyle, Max A Little, A. Loudon, A. Luik, F. Scheer, K. Spiegelhalder, J. Tyrrell, D. J. Gottlieb, Henning Tiemeier, David W. Ray, Shaun M. Purcell, T. Frayling, S. Redline, D. A. Lawlor, Martin K Rutter, M. Weedon, Richa Saxena   +31 more
semanticscholar   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors

Pharmacogenomics and Personalized Medicine, 2021
Zixiu Zhou, Sizhen Li, Qingsong Yang, Xiaodong Yang, Kuanxiao Hao, Yating Liu, Shanshan Xu Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, 211102, People’s Republic of ChinaCorrespondence: Sizhen LiNanjing Tongren ...
Zhou Z, Li S, Yang Q, Yang X, Hao K, Liu Y, Xu S   +6 more
doaj  

Genome-Wide Association Study Identifies Candidate Loci Associated with Platelet Count in Koreans [PDF]

Genomics & Informatics, 2014
Platelets are derived from the fragments that are formed from the cytoplasm of bone marrow megakaryocytes-small irregularly shaped anuclear cells. Platelets respond to vascular damage, contracts blood vessels, and attaches to the damaged region, thereby ...
Ji Hee Oh, Yun Kyoung Kim, Sanghoon Moon, Young Jin Kim, Bong-Jo Kim   +4 more
doaj   +1 more source