Results 81 to 90 of about 3,155,630 (345)

A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain [PDF]

, 2014
BACKGROUND: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients.
, , Colhoun, H. M., Deshmukh, H. A., Donnelly, L. A., Liu, Y., Meng, W., Morris, A. D., Palmer, C. N. A., Smith, B. H., van Zuydam, N. R., Zhou, K.   +11 more
core   +4 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders [PDF]

, 2017
Twin studies indicate that latent genetic factors overlap across comorbid psychiatric disorders. In this study, we used a novel approach to elucidate shared genetic factors across psychiatric outcomes by clustering single nucleotide polymorphisms based ...
Adkins, Amy E., Aliev, Fazil, Bucholz, Kathleen K., Cho, Seung Bin, Clark, Shaunna L., Dick, Danielle M., Edenberg, Howard J., Porjesz, Bernice   +7 more
core   +1 more source

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

Nature Communications, 2019
Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) scores and ...
H. Kranzler, Hang Zhou, R. Kember, Rachel Vickers Smith, A. Justice, S. Damrauer, P. Tsao, D. Klarin, A. Baras, Jeffrey Reid, J. Overton, D. Rader, Zhongshan Cheng, J. Tate, W. Becker, J. Concato, Ke Xu, R. Polimanti, Hongyu Zhao, J. Gelernter   +19 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Genome-Wide Association Study Reveals Candidate Genes for Litter Size Traits in Pelibuey Sheep

Animals, 2020
The Pelibuey sheep has adaptability to climatic variations, resistance to parasites, and good maternal ability, whereas some ewes present multiple births, which increases the litter size in farm sheep.
Wilber Hernández-Montiel, Mario Alberto Martínez-Núñez, Julio Porfirio Ramón-Ugalde, Sergio Iván Román-Ponce, Rene Calderón-Chagoya, Roberto Zamora-Bustillos   +5 more
doaj   +1 more source

Common variation near ROBO2 is associated with expressive vocabulary in infancy [PDF]

, 2014
Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers
Ang, Qi W., Cents, Rolieke A. M., Dale, Philip S., Davis, Oliver S. P., Evans, David M., Golding, Jean, Haworth, Claire M. A., Hofman, A., Jaddoe, Vincent Wilfred Vishal-Kapoor, Jarvelin, Marjo-Riitta, Kemp, John P., Meaburn, Emma L., Miller, Laura, O’Reilly, Paul F., Pennell, Craig E., Pillas, Demetris, Plomin, Robert, Price, Tom S., Ring, Susan M., Rivadeneira, Fernando, Rodriguez, Alina, Roulstone, Susan, Smith, George Davey, St Pourcain, Beate, Tiemeier, Henning, Timpson, Nicholas J., Velders, F. P., Verhulst, F. C., Warrington, Nicole M., Whitehouse, Andrew J. O., Wren, Yvonne, Yliherva, Anneli   +31 more
core   +9 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Characterization of Insect Resistance Loci in the USDA Soybean Germplasm Collection Using Genome-Wide Association Studies

Frontiers in Plant Science, 2017
Management of insects that cause economic damage to yields of soybean mainly rely on insecticide applications. Sources of resistance in soybean plant introductions (PIs) to different insect pests have been reported, and some of these sources, like for ...
Hao-Xun Chang, Glen L. Hartman
doaj   +1 more source

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Diabetes, 2017
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using ...
R. Scott, L. Scott, R. Mägi, L. Marullo, K. Gaulton, M. Kaakinen, N. Pervjakova, T. Pers, Andrew D. Johnson, J. Eicher, A. Jackson, T. Ferreira, Yeji Lee, Clement Ma, V. Steinthorsdottir, G. Thorleifsson, L. Qi, Natalie R. van Zuydam, A. Mahajan, Han Chen, P. Almgren, B. Voight, H. Grallert, M. Müller-Nurasyid, J. Ried, N. W. Rayner, N. Robertson, L. Karssen, E. V. van Leeuwen, Sara M. Willems, C. Fuchsberger, P. Kwan, Tanya M. Teslovich, Pritam Chanda, Man Li, Yingchang Lu, C. Dina, Dorothée Thuillier, L. Yengo, Longda Jiang, T. Sparsø, H. Kestler, H. Chheda, L. Eisele, S. Gustafsson, Mattias Frånberg, R. Strawbridge, R. Benediktsson, Á. Hreidarsson, A. Kong, G. Sigurðsson, N. Kerrison, J. Luan, L. Liang, T. Meitinger, M. Roden, B. Thorand, T. Esko, E. Mihailov, C. Fox, Ching‐Ti Liu, Denis Rybin, B. Isomaa, V. Lyssenko, T. Tuomi, D. Couper, J. Pankow, N. Grarup, C. Have, M. Jørgensen, T. Jørgensen, A. Linneberg, M. Cornelis, R. V. van Dam, D. Hunter, P. Kraft, Qi Sun, S. Edkins, K. Owen, J. Perry, A. Wood, E. Zeggini, Juan Tajes-Fernandes, G. Abecasis, L. Bonnycastle, P. Chines, H. Stringham, H. Koistinen, L. Kinnunen, B. Sennblad, Thomas W. Mühleisen, M. Nöthen, S. Pechlivanis, D. Baldassarre, K. Gertow, S. Humphries, E. Tremoli, N. Klopp, Julia Meyer, G. Steinbach, R. Wennauer, J. Eriksson, S. Mӓnnistö, L. Peltonen, E. Tikkanen, G. Charpentier, Elodie Eury, S. Lobbens, B. Gigante, K. Leander, O. Mcleod, E. Bottinger, O. Gottesman, D. Ruderfer, M. Blüher, P. Kovacs, Anke Tonjes, N. Maruthur, C. Scapoli, R. Erbel, K. Jöckel, S. Moebus, U. de Faire, A. Hamsten, M. Stumvoll, P. Deloukas, P. Donnelly, T. Frayling, A. Hattersley, S. Ripatti, V. Salomaa, N. Pedersen, B. Boehm, R. Bergman, F. Collins, K. Mohlke, J. Tuomilehto, T. Hansen, O. Pedersen, I. Barroso, L. Lannfelt, E. Ingelsson, L. Lind, C. Lindgren, S. Cauchi, P. Froguel, R. Loos, B. Balkau, H. Boeing, P. Franks, A. Barricarte Gurrea, D. Palli, Y. T. van der Schouw, D. Altshuler, L. Groop, C. Langenberg, N. Wareham, E. Sijbrands, C. V. van Duijn, J. Florez, J. Meigs, E. Boerwinkle, C. Gieger, K. Strauch, A. Metspalu, A. D. Morris, C. Palmer, F. Hu, U. Thorsteinsdóttir, K. Stefánsson, J. Dupuis, Andrew P. Morris, M. Boehnke, M. McCarthy, I. Prokopenko   +174 more
semanticscholar   +1 more source