Results 91 to 100 of about 3,210,341 (315)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes [PDF]

, 2014
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies ...
Rasmussen-Torvik, Laura J., Ayo Doumatey, Jennifer A. Pacheco (496628), MEDIA Consortium (), Daniel S. Evans (230365), Dhananjay Vaidya, Liu, YM, Loren L Armstrong, McKnight, Barbara, Lynne Wagenknecht (610797), Boerwinkle, E., Zhao, W, Fornage, Myriam, M Geoffrey Hayes, Beverly M. Snively (156128), Palmer, N.D., Becker, Diane M, Langefeld, Carl D, Goodarzi, Mark O., Sudha K. Iyengar (129292), James G. Wilson (113688), Mathias, Rasika A, Peyser, Patricia A., Chen, B.H., Myriam Fornage (45591), Kao, W.H.L., Jensen Richard A., Rice Kenneth, Liu Simin, Borecki, IB, Kraja, A, Borecki, Ingrid B., Yanek, LR, Yang Lingyao, Palmer Nicholette D., Rasmussen-Torvik, Laura J, Kabagambe, E.K., Lowe, W.L., Adeyemo Adebowale, Leslie J Raffel, Laura J. Rasmussen-Torvik (174672), Iyengar, S.K., Palmer, Nicholette D, Doumatey, A, Boerwinkle, Eric, Bowden, Donald W, Nalls, Michael A., Doumatey, Ayo, Xiuqing Guo (73591), Armstrong, Loren L., Zhao, Wei, Evans, Michele K., Chen, Y.-D. Ida, Boerwinkle, E, Bowden, D.W., Y-D Ida Chen (610799), Dana C. Crawford (102216), Pacheco, J.A., Taylor, HA, Chen, Brian H, Guanjie Chen, Evans, DS, Raffel, LJ, William L Lowe, Rich, Stephen S., Alan B. Zonderman (178692), Sedor, J.R., Hsueh, Wen-Chi, Chen, Guanjie, Jensen, Richard A., Wen-Chi Hsueh, Ping An (24129), Couper, David J., Michael A Province, Mudgal, P., Becker, D.M., Dana C Crawford, Andrew B. Singleton (178128), Guo Xiuqing, Crawford, DC, Barry I. Freedman (120811), Lu, YC, Langefeld, CD, Vaidya, Dhananjay, Cummings, Steven R, Taylor, H.A.J., Goodarzi Mark O., Rasmussen-Torvik, LJ, Bielak Lawrence F., Lu, Y., Jirong Long, Simin Liu, Erwin P. Bottinger (3212694), Zonderman Alan B., ?, ?, Sale Michèle M., Wei Zhao, Freedman, BI, Blot, William J., Steven R Cummings, Aldi Kraja, McKnight, B., Pankow James S., Cummings, Steven R., Lu, Yingchang, Province, MA, Peyser, PA, Borecki, Ingrid B, Ping An, Kao, WH Linda, Raffel Leslie J., Rotimi, Charles N, Nalls, M.A., Nicholette D. Palmer (190239), Shu, X.O., Jennifer A Pacheco, McKnight Barbara, Robert P. Igo Jr. (5660086), Aldi Kraja (73605), Vaidya, D, James S Pankow, Chen, Y-D Ida, Sedor, John R., Sedor, John R, Guo, Xiuqing, MuTHER Consortium (), Leslie J. Raffel (610798), Rice, Kenneth, Sun, Y.V., Keene Keith L., Wei Zheng, Lawrence F Bielak, Mark O. Goodarzi (123440), Wagenknecht Lynne, Crawford, D.C., FIND Consortium (), Li, Jiang, Herman A. Taylor Jr. (5660083), Adebowale Adeyemo, Xiao-Ou Shu, Bielinski, S.J., Mathias, Rasika A., Armstrong, LL, Rotimi, CN, Hayes, M Geoffrey, David S. Siscovick (174822), Chen Wei-Min, Sale, Michèle M., Rotter, Jerome I, Maggie C. Y. Ng (190281), An, P., Rice, K., Mudgal Poorva, Bowden, Donald W., Long, Jirong, Hayes, MG, David S Siscovick, Lowe, WL, Singleton, Andrew B., Adolfo Correa, Igo Robert P., Yanek Lisa R., Loos, Ruth J. F., Yanek, Lisa R, DIAGRAM Consortium, Barbara McKnight, Ng, MCY, Loos, RJF, Bowden Donald W., Raffel, L.J., Yingchang Lu, Nicholette D Palmer, Diane M Becker, Sims, M, Armstrong, L.L., Evans, M.K., Wilson, James G, Adeyemo, Adebowale, Omri Gottesman, Palmer, Nicholette D., Sun, Yan V, Jensen, R.A., Chen Brian H., Couper David, Langefeld Carl D., Shu, X., Lawrence F. Bielak (446522), Josyf C. Mychaleckyj (171602), Nayak Uma, Sun, Yan V., Long Jirong, Sims Mario, Kraja Aldi, Ng Maggie C. Y., Laura J Rasmussen-Torvik, Chen, Y.I., Goodarzi, Mark O, Chen, Brian H., Province Michael A., Rasika A Mathias, Grundberg, E, Comeau, Mary E, Mychaleckyj, JC, Keene, K.L., James S. Pankow (174656), Igo, R.P., Wagenknecht, Lynne, Rich Stephen S., Mychaleckyj, Josyf C., Bruce M Psaty, Snively Beverly M., Hayes M. Geoffrey, Freedman, B.I., Ruth J F Loos, Armstrong Loren L., Vaidya Dhananjay, Shriner, D, Yingchang Lu (149264), DIAGRAM Consortium (Gieger, C. ; Grallert, H. ; Illig, T. ; Klopp, N. ; Müller-Nurasyid, M. ; Peters, A.), Gottesman, O., Rotter Jerome I., Lingyao Yang (215359), M. Geoffrey Hayes (327753), Kao, WHL, Rotter, J.I., An Ping, William J. Blot (191278), Yang, LY, Nalls, Michael A, Couper, David, Bottinger, Erwin P, Loren L. Armstrong (529937), Crawford, Dana C, Grundberg Elin, Carl D. Langefeld (120828), Kraja, A., Pacheco, Jennifer A., John R. Sedor (306528), Patel, S.R., Michèle M Sale, Correa, A, Chen, GJ, Bottinger, Erwin P., Guo, XQ, Wilson, James G., Pankow, James S., Suzette J Bielinski, W H Linda Kao, Jerome I. Rotter (103729), Singleton, A.B., Yongmei Liu, Myriam Fornage, Bottinger Erwin P., Eric Boerwinkle, Becker, Diane M., Patel, Sanjay R., Yang, L., Evans Daniel S., Rotimi, Charles N., Langefeld, Carl D., Sale, M.M., Keith L Keene, Sale, MM, Peyser Patricia A., Chen, G., Zheng, W, Blot, W.J., Patel, Sanjay R, Diane M. Becker (113669), Sudha K Iyengar, Doumatey Ayo, Keene, KL, Iyengar Sudha K., Lynne Wagenknecht, Ayo Doumatey (255558), W. H. Linda Kao (160779), Chen, Y.-D.I., Hsueh Wen-Chi, Armstrong, Loren L, Pacheco Jennifer A., Gottesman, O, Sims, Mario, Brian H. Chen (610796), Daniel S Evans, Gottesman, Omri, Goodarzi, MO, Michael A. Province (53600), Elin Grundberg, Mychaleckyj, Josyf C, Robert P Igo, Rotter, JI, David Couper (215307), Zonderman, Alan B., Becker, DM, Psaty, Bruce M., Daniel Shriner, Y-D Ida Chen, Charles N. Rotimi (137216), Bielak, L.F., Lowe, William L., Long, J., Bielak, Lawrence F, Liu, J., Taylor, Herman A, Kenneth Rice, Jiankang Liu, Evans, Daniel S, Zonderman, Alan B, Mathias, RA, Raffel, Leslie J., Beverly M Snively, Zheng Wei, Kraja, Aldi, Liu, JK, Michele K Evans, Zheng, W., An, P, Wei Zhao (14321), Jirong Long (181371), Kao W. H. Linda, Borecki Ingrid B., Wilson James G., Cummings, S.R., Patricia A Peyser, Guanjie Chen (28943), Zonderman, AB, Cummings, SR, Richard A. Jensen (103656), Jiankang Liu (48049), Taylor, H.A., Fornage Myriam, Uma Nayak (446511), Ruth J. F. Loos (110224), Sims, M., Bielinski Suzette J., Poorva Mudgal (522965), Mario Sims, Kabagambe, Edmond K., Guo, X., Chen, BH, Patel, SR, Josyf C Mychaleckyj, Rasika A. Mathias (134405), Ng, Maggie CY, Donald W Bowden, Mudgal, P, Psaty, Bruce M, Doumatey, A., William L. Lowe (610802), Mathias Rasika A., Igo, Robert P., Shriner Daniel, Nayak, U, Simin Liu (11987), Charles N Rotimi, Grundberg, Elin, Michael A. Nalls (113680), Correa Adolfo, Long, JR, Bottinger, EP, Qiuyin Cai (25449), Bielinski, SJ, Liu, Jiankang, Mary E. Comeau (192855), Igo, R.P.J., Wilson, J.G., Edmond K Kabagambe, Jiang Li, Adeyemo, A, Mark O Goodarzi, Mario Sims (412259), Siscovick, DS, Uma Nayak, Bielak, LF, Evans, MK, Elin Grundberg (116416), Mudgal, Poorva, McKnight, B, Freedman Barry I., Cai Qiuyin, Province, M.A., Hayes, M.G., Blot, WJ, Correa, A., Rich, SS, Lisa R Yanek, MEta-analysis of type 2 DIabetes in African Americans Consortium, Singleton Andrew B., Langefeld, C.D., Mychaleckyj, J.C., Shu, XO, Freedman, Barry I, Sanjay R. Patel (120915), Becker Diane M., Lingyao Yang, Edmond K. Kabagambe (127046), Palmer, ND, Jiang Li (272926), Siscovick David S., Igo, RP, Wen-Chi Hsueh (264276), Michèle M. Sale (113676), Chen Guanjie, Comeau, ME, Li, J, Cummings Steven R., Keene, Keith L, Iyengar, Sudha K., Xiao-Ou Shu (25450), Ingrid B. Borecki (113678), Fornage, M., Singleton, Andrew B, Zheng, Wei, Bruce M. Psaty (103721), Shriner, Daniel, Bielak, Lawrence F., Kabagambe Edmond K., Evans, Daniel S., Eric Boerwinkle (36288), Chen, Wei-Min, Rasmussen-Torvik Laura J., Wei-Min Chen (110472), Comeau, M.E., Rasmussen-Torvik, L.J., Sedor John R., Liu, SM (Simin), William J Blot, Patricia A. Peyser (446515), Wei Zheng (25452), Ng, Maggie C. Y., Pacheco, JA, Jensen, Richard A, Hayes, M. Geoffrey, Jerome I Rotter, Siscovick, David S., Kabagambe, Edmond K, Liu, Simin, Kabagambe, EK, Nayak, Uma, Michele K. Evans (27920), Maggie C Y Ng, Yanek, L.R., Rich, S.S., Gottesman Omri, Chen, YDI, Keene, Keith L., Bowden, DW, Couper, D, Mychaleckyj Josyf C., Crawford, Dana C., Raffel, Leslie J, Liu, Yongmei, Sun Yan V., Yanek, Lisa R., Grundberg, E., Liu, S., Rice, K, Ingrid B Borecki, Hsueh, W.C., Snively, Beverly M, Province, Michael A., Peyser, P.A., Crawford Dana C., Rotimi Charles N., Li, J., Comeau Mary E., Boerwinkle Eric, Cai, Q., Freedman, Barry I., Vaidya, D., Barry I Freedman, David Couper, Poorva Mudgal, Nalls, MA, Pacheco, Jennifer A, Hsueh, WC, Fornage, M, Bottinger, E.P., Zhao, W., Cai, Qiuyin, John R Sedor, Snively, B.M., Igo, Robert P, Adolfo Correa (610800), Shu Xiao-Ou, Qiuyin Cai, Siscovick, D.S., Pankow, JS, Comeau, Mary E., Siscovick, David S, FIND Consortium, Rotimi, C.N., Sale, Michèle M, Erwin P Bottinger, Iyengar, Sudha K, Cai, QY, Taylor Herman A., Taylor, Herman A., Sedor, JR, Mathias, R.A., Michael A Nalls, Zhao Wei, Loos Ruth J. F., Yan V Sun, Evans, Michele K, Liu Yongmei, Suzette J. Bielinski (262597), Omri Gottesman (133442), Nalls Michael A., Donald W. Bowden (120806), Shriner, D., Yang, Lingyao, Rich, Stephen S, An, Ping, Adeyemo, A., Blot, William J, Goodarzi, M.O., Sanjay R Patel, Alan B Zonderman, Pankow, James S, Lowe, William L, Daniel Shriner (137188), Xiuqing Guo, Bielinski, Suzette J., Wagenknecht, L, Lisa R. Yanek (113564), Chen Y-D Ida, Psaty, BM, Snively, Beverly M., Adebowale Adeyemo (28944), Wagenknecht, L., Evans Michele K., Steven R. Cummings (361400), Bielinski, Suzette J, Herman A Taylor, Andrew B Singleton, Loos, R.J.F., Psaty, B.M., MuTHER Consortium, Wilson, JG, Barbara McKnight (103714), Brian H Chen, Iyengar, SK, Stephen S. Rich (110262), Ng, M.C.Y., Hsueh, W., Lu Yingchang, Province, Michael A, Singleton, AB, Pankow, J.S., Carl D Langefeld, Zonderman, A.B., Jensen, RA, Chen, WM, Psaty Bruce M., Couper, D., Stephen S Rich, Sun, YV, Correa, Adolfo, Yan V. Sun (446508), Shu, Xiao-Ou, Blot William J., Borecki, I.B., James G Wilson, Kao, W. H. Linda, Evans, D.S., Nayak, U., Peyser, Patricia A, Snively, BM, Mary E Comeau, Liu, Y., Richard A Jensen, Chen, W., Rotter, Jerome I., Wei-Min Chen, Lowe William L., Dhananjay Vaidya (149887), eMERGE Consortium, Liu Jiankang, Kenneth Rice (211836), Yongmei Liu (104713), Patel Sanjay R., eMERGE Consortium (), Keith L. Keene (540212), Li Jiang, Loos, Ruth JF   +585 more
core   +1 more source

Genome-wide identification of significant aberrations in cancer genome

BMC Genomics, 2012
Background Somatic Copy Number Alterations (CNAs) in human genomes are present in almost all human cancers. Systematic efforts to characterize such structural variants must effectively distinguish significant consensus events from random background ...
Yuan Xiguo, Yu Guoqiang, Hou Xuchu, Shih Ie-Ming, Clarke Robert, Zhang Junying, Hoffman Eric P, Wang Roger R, Zhang Zhen, Wang Yue   +9 more
doaj   +1 more source

Canadian polar bear population structure using genome‐wide markers

Ecology and Evolution, 2020
Predicting the consequences of environmental changes, including human‐mediated climate change on species, requires that we quantify range‐wide patterns of genetic diversity and identify the ecological, environmental, and historical factors that have ...
Evelyn L. Jensen, Christina Tschritter, Peter V. C. deGroot, Kristen M. Hayward, Marsha Branigan, Markus Dyck, Rute B. G. Clemente‐Carvalho, Stephen C. Lougheed   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA [PDF]

, 2012
Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.
Palmer Cameron D., Marjo-Riitta Jarvelin, Coin, Lachlan, Matthew A. Brown (131482), Ferreira, Manuel, O'Connor, George T, Guy B Marks, Dharmage, Shyamali C, Adaikalavan Ramasamy (4841), Anneli Pouta, Lehtimäki Terho, Tari Haahtela, Veikko Salomaa (62543), Shyamali C. Dharmage, Manuel A R Ferreira, Lehtimaki, Terho, Anneli Pouta (116626), Pekkanen Juha, Joel N Hirschhorn, Gajdos, Zofia K, Strachan David P., Palotie Aarno, Colin F. Robertson (131511), Philip J Thompson, Lehtimäki, T, Montgomery, Grant, Andrew C. Heath, Duffy David L., Strachan, David P, Elisabeth Widen (75580), Matthias Wjst (56613), Thompson, Philip, David L. Duffy (131489), Martin, Nicholas G., Laitinen, Tarja, Hirschhorn, Joel, Raitakari, Olli T, Alexessander Couto Alves, Tarja Laitinen, Lyon, Helen, Wareham, Nick, Laitinen Tarja, Palmer, CD, Raitakari Olli T., Peter Le Souef, Christer Janson, Vedantam, Sailaja, Janson Christer, Sailaja Vedantam (131467), George T. O'Connor (110263), Marks Guy B., Ramasamy, Adaikalavan, Ferreira, Manuel AR, Andrew C Heath, Peter Le Souef (131503), David P Strachan, Palotie, Aarno, Eriksson, Johan, Jing Hua Zhao (73808), Jorma Viikari, Tari Haahtela (131492), Nick Wareham, Grant W. Montgomery (131518), Heathe, Andrew C, Khaw, KT, Nicholas G. Martin (113568), Jarvelin, Marjo-Riitta, Robertson, CF, Mika Kähönen (131499), Michael J. Abramson, Matheson, M C, Kay-Tee Khaw, Pouta, Anneli, David P. Strachan, Abramson, Michael J, Manuel A. R. Ferreira, Aarno Palotie (41342), Juha Pekkanen (27303), Palotie, A, Mikko Kuokkanen, Ferreira, MA, Marks, Guy B., Helen N Lyon, Philip J. Thompson (131523), Cameron D Palmer, Deborah L. Jarvis (131514), Thompson, Philip J., Colin F. Robertson, Janson, Christer,, Heath, Andrew C, Madden, Pamela AF, Kuokkanen Mikko, Strachan, David P., Salomaa, Veikko, Jaana Laitinen (116629), Coin, L, Haahtela, T, Widen Elisabeth, Ramasamy, A, Martin, NG, Janson, C, Madden, PA, Eriksson, J, Laitinen Jaana, Thompson Philip J., Couto Alves, A, Matheson, Melanie C, Australian Asthma Genetics, Martin Nicholas G., ?, ?, Salomaa, V, Zhao, Jing Hua, Olli T Raitakari, Palmer, Cameron D, David L Duffy, Jarvis Deborah L., Palmer, Cameron, Widen, Elizabeth, Zofia K. Gajdos (131468), Matheson, Melanie C., Widen, Elisabeth, O'Connor George T., Martin, Nicholas, Raitakari, OT, O'Connor, George, Kähönen Mika, Colin F Robertson, O'Connor, GT, Kähönen, M, Gajdos, Zofia, Duffy, David L., Lachlan Coin (3863), Jarvelin Marjo-Riitta, Dharmage Shyamali C., Dharmage, Shyamali C., Raitakari, Olli T., Jousilahti, P, Hirschhorn Joel N., Pekka Jousilahti, Ferreira Manuel A. R., Lyon, Helen N., Guy B. Marks (116572), Martin, Nicholas G, Nicholas G Martin, Brown, MA, Marks, Guy, Michael J. Abramson (131480), Pekkanen, Juha, Lyon, HN, Matheson Melanie C., Pekkanen, J, Madden Pamela A. F., Duffy, DL, Heath, AC, Gajdos Zofia K., Olli T. Raitakari (115559), Lachlan Coin, Lyon, Helen N, Camerond Palmer, Nicholas G. Martin, Strachan, David, Jousilahti Pekka, Jousilahti, Pekka, Dharmage, Shyamali, Pamela A. F. Madden (127156), Veikko Salomaa, Madden, Pamela, Wjst Matthias, Zofia K. Gajdos, Marks, GB, Matthew A Brown, Manuel A. R. Ferreira (131476), Khaw, Kay-Tee, Jarvis, Deborah L., Kahonen, Mika, Montgomery, GW, Montgomery, Grant W, Eriksson Johan, Pouta, A, Viikari, J, Heath Andrew C., Johan Eriksson, Shyamali C. Dharmage (131486), Laitinen, T, Laitinen, J, Johan Eriksson (131534), Pekka Jousilahti (131538), David L. Duffy, Palmer, Cameron D., Palmer, Cameron Douglas, George T O'Connor, Duffy, David, Viikari, E, Jaana Laitinen, Kay-Tee Khaw (110271), Viikari Jorma, Matheson, MC, Mikko Kuokkanen (131465), Khaw Kay-Tee, Matthew A. Brown, Thompson, Philip J, Montgomery Grant W., Le Souef, P, Robertson, Colin, Jarvis, Debbie, Mika Kähönen, Pamela A F Madden, Melanie C Matheson, Pouta Anneli, Alexessander Couto Alves (131470), Andrew C. Heath (127152), Tarja Laitinen (131542), George T. O’connor, Viikari, Jorma, Aarno Palotie, O'Connor, George T., Melanie C. Matheson (131507), Lyon Helen N., Marks, Guy B, Joel N. Hirschhorn, Ramasamy Adaikalavan, Terho Lehtimäki (49739), Juha Pekkanen, Marjo-Riitta Jarvelin (110290), Heathe, Andrew, Abramson Michael J., Heath, Andrew C., Wareham Nick, Gajdos, ZK, Zhao, Jing, Brown, Matthew A, Deborah L. Jarvis, Matheson, M, Abramson, Michael, Michael J Abramson, Christer Janson (83414), Jarvelin, MR, Adaikalavan Ramasamy, Duffy, David L, Jing Hua Zhao, Zhao Jing Hua, Jorma Viikari (49741), Montgomery, Grant W., Brown, Matthew A., Vedantam Sailaja, Robertson Colin F., Wjst, Matthias, Cameron D. Palmer (131509), David P. Strachan (110302), Hirschhorn, Joel N., Ferreira, Manuel A. R., Er Couto Alves, Thompson, PJ, Raitakari, Olli, Brown, Matthew, Laitinen, Jaana, Haahtela Tari, Grant W Montgomery, Brown Matthew A., Alves, Alexessander Couto, Robertson, Colin F., Matthias Wjst, Olli T. Raitakari, Zhao, JH, Couto Alves, Alexessander, Shyamali C Dharmage, Melanie C. Matheson, Gajdos, Zofia K., Kuokkanen, M, Widen, E, Hirschhorn, Joel N, Salomaa Veikko, Deborah L Jarvis, Janson, Christer, Guyb. Marks, Le Souef, Peter, Le Souef Peter, Wareham, N, Haahtela, Tari, Kuokkanen, Mikko, Hirschhorn, JN, Vedantam, S, Dharmage, SC, Jarvis, DL, Jarvis, Deborah L, Couto Alves Alexessander, Strachan, DP, Nick Wareham (131528), Pamela A. F. Madden, Abramson, MJ, Coin Lachlan, Elisabeth Widen, Madden, Pamela A, Zofia K Gajdos, Wjst, M, Sailaja Vedantam, Grant W. Montgomery, Robertson, Colin F, Philip J. Thompson, Helen N. Lyon (131473), Australian Asthma Genetics Consortium Collaborators, Abramson, Michael J., Joel N. Hirschhorn (131545), Terho Lehtimäki, Helen N. Lyon, Madden, Pamela A. F.   +305 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importnace of Lp(a) [PDF]

, 2012
We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and the ...
Postmus, Iris, Colhoun, H.M., McKeigue, Paul M, Stanton, A.V., Trompet, S., Hyde, Craig, Colhoun, Helen M, Caulfield, M., Shields, Denis C., Hitman, Graham A, CARDS, Poulter, Neil, Shields, D.C., Sever, P., Chatterjee, Aurobindo, Trompet, Stella, Durrington, Paul N, Deshmukh, H.A., DeMicco, D.A., Calle, Roberto A., Hitman, Graham A., Neil, A., McKeigue, Paul M., Fuller, John H., Postmus, I., Hitman, G.A., DeMicco, David A., Johnson, T., ?, ?, Calle, Roberto A, Betteridge, D.J., Livingstone, Shona, Ford, Ian, McKeigue, P.M., Stanton, Alice V., Jukema, J.W., Johnson, Toby, Durrington, Paul N., Neil, Andrew, PROSPER Investigators, Livingstone, S., Jukema, J. Wouter, ASCOT, Colhoun, Helen, Ford, I., Sever, Peter, Fuller, J.H., Jukema, J Wouter, Caulfield, Mark, Fuller, John H, Chatterjee, A., Deshmukh, Harshal A, Calle, R.A., Hyde, C., Charlton-Menys, V., Poulter, N., Charlton-Menys, Valentine, DeMicco, David A, Betteridge, D John, McKeigue, Paul M.; id_orcid, Betteridge, D. John, Durrington, P.N., Colhoun, Helen M., Shields, Denis C, Deshmukh, Harshal A., Stanton, Alice V   +65 more
core   +1 more source

An Analysis Pipeline for Genome-wide Association Studies

Cancer Informatics, 2008
We developed an efficient pipeline to analyze genome-wide association study single nucleotide polymorphism scan results. Perl scripts were used to convert genotypes called using the BRLMM algorithm into a modified PB format.
Stefan Stefanov, James Lautenberger, Bert Gold   +2 more
doaj