Results 191 to 200 of about 1,251,540 (276)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Design and Application of a Genome-Wide SNP Array to Improve Conservation Outcomes in the Critically Endangered Southern Corroboree Frog. [PDF]

Mol Ecol Resour
Davidson MJ, Zenger KR, Keogh JS, Berger L, Skerratt LF, Kosch TA.   +5 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Towards responsible genome-wide screening

Plantinga M, Ploem MC, Longaron SS, NIebuur J, Christiaans I, Birnie E, Henneman L, Rigter T, Cornel M, Stemkens D, Yntema H, Hout Svd, de Wert G.   +12 more
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Genome-Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes. [PDF]

Adv Sci (Weinh)
Wang S, Wang M, Zhang P, Cheng J, Zhang L, Zhu W, Qiu S, Geng Z, Cui G, Yu Y, Liao W, Zuo XN, Zhang H, Gao B, Xu X, Han T, Yao Z, Zhang Q, Liu F, Xu Q, Xu J, Fu J, Liu N, Ji Y, Tang J, Guo L, Liu M, Xiao X, Liu X, Li W, Wang C, Wei W, Shi D, Lui S, Yan Z, Chen F, Zhang J, Shen W, Miao Y, Wang D, Gao JH, Yang Y, Xu K, Xian J, Zhang B, Zhang X, Ye Z, Yu L, Qin W, Liang M, Yu C, CHIMGEN Consortium.   +51 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's disease via genome-wide association studies. [PDF]

Alzheimers Dement
Kim JP, Song M, Cho M, Lee H, Jung SH, Lim S, Kim C, Jang B, Shin D, Kang H, Yim S, Jang H, Kim BH, Kim HJ, Na DL, An JY, Zetterberg H, Blennow K, Gonzalez-Ortiz F, Ashton NJ, Day TA, Seo SW, Won HH.   +22 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Genome-wide association study of male sexual orientation [PDF]

, 2017
Cloninger, C. Robert, et al,, Svrakic, Dragan M   +2 more
core   +1 more source