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Genome-wide and allele-resolved maps of the radial architecture of the mouse genome
Bienko M +8 more
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Inbreeding in genome‐wide selection
Journal of Animal Breeding and Genetics, 2007SummaryTraditional selection methods, such as sib and best linear unbiased prediction (BLUP) selection, which increased genetic gain by increasing accuracy of evaluation have also led to an increased rate of inbreeding per generation (ΔFG). This is not necessarily the case with genome‐wide selection, which also increases genetic gain by increasing ...
Daetwyler, H.D. +3 more
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Genome‐wide androgenetic mosaicism
Clinical Genetics, 2013Individuals with mosaic paternal uniparental disomy (UPD) of apparently all chromosomes have recently been described. They show a 46,XX karyotype, but with a mixture of normal biparental cells and cells entirely of paternal isodisomic origin. We describe an infant who primarily showed signs of Beckwith–Wiedemann syndrome (BWS), but also had other ...
J P, Johnson +3 more
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Genome-Wide Association Studies
2012A host of data on genetic variation from the Human Genome and International HapMap projects, and advances in high-throughput genotyping technologies, have made genome-wide association (GWA) studies technically feasible. GWA studies help in the discovery and quantification of the genetic components of disease risks, many of which have not been unveiled ...
Tun-Hsiang, Yang +2 more
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Current Opinion in Chemical Biology, 2001
In many species, double-stranded RNA can specifically and effectively silence genes. This newly discovered biological phenomenon, called RNA interference (RNAi), has practical implications for functional genomics. As shown by two recent reports, RNAi provides a rapid method to test the function of genes in the nematode Caenorhabditis elegans; most of ...
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In many species, double-stranded RNA can specifically and effectively silence genes. This newly discovered biological phenomenon, called RNA interference (RNAi), has practical implications for functional genomics. As shown by two recent reports, RNAi provides a rapid method to test the function of genes in the nematode Caenorhabditis elegans; most of ...
openaire +2 more sources
On transferability of genome‐wide tagSNPs
Genetic Epidemiology, 2007AbstractThe question of tagging single nucleotide polymorphism (tagSNP) transferability is an important one because many ongoing and upcoming Genome‐Wide Association studies rely critically upon the validity, and practical feasibility of using a universal core set of tagSNPs.
C Charles, Gu +4 more
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A Genome-Wide Perspective on Metabolism
2015Mammals have at least 210 histologically diverse cell types (Alberts, Molecular biology of the cell. Garland Science, New York, 2008) and the number would be even higher if functional differences are taken into account. The genome in each of these cell types is differentially programmed to express the specific set of genes needed to fulfill the ...
Rauch, Alexander, Mandrup, Susanne
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