Results 191 to 200 of about 3,210,341 (315)

Genetic control of wheat flour end-use quality and rheology by genome-wide association studies. [PDF]

Plant Genome
Menor de Gaspar J, Cuthbert RD, Yuefeng R, Knox R, Fu B, Wang K, Sangah JS, Berraies S, Meyer B, Bokore FE, Isidro Y Sánchez J.   +10 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Elevated MyoD1 levels expand genome-wide binding and the repertoire of regulated genes. [PDF]

Proc Natl Acad Sci U S A
Whitney ON, Dailey GM, McKenna JK, Darzacq X, Tjian R.   +4 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

P540: Genome-wide Sequencing Ontario (GSO): Canada’s first provincial clinical genome-wide sequencing service

Genetics in Medicine Open
Meredith Gillespie, Robin Hayeems, Christian Marshall, Anna Szuto, Caitlin Chisholm, James Stavropoulos, Lijia Huang, Lynette Lau, Wilson Sung, Melanie Beaulieu Bergeron, Ted Higginbotham, Meredith Curtis, Venuja Sriretnakumar, Hassan Zaidi, Emma Hitchcock, Audrey Schaffer, Taila Hartley, Sarah Sawyer, Wendy Ungar, Gregory Costain, Roberto Mendoza-Londono, Anna Pan, Jennifer Keating, Diana Matviychuk, Tamara Braid, Niri Carroll, Martin Somerville, Kym Boycott   +27 more
doaj   +1 more source

Evolution of genome-wide barriers to gene flow during complex speciation in rattlesnakes. [PDF]

Proc Natl Acad Sci U S A
Farleigh K, Highland DK, Alderman MG, Francioli Y, Hirst SR, Faber EM, Perry BW, Holding ML, Castañeda-Gaytán G, Borja M, Franz-Chávez H, Parkinson CL, Strickland JL, Margres MJ, Mackessy SP, Meik JM, Castoe TA, Schield DR.   +17 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Genome-Wide 6mA Map Unveils Epigenetic Adaptation in Deep-Sea Limpet. [PDF]

Ecol Evol
Chen C, Liu J, Zhuang R, Ni K, Wang M, Li Y, Wang J, Wang S, Han W, Bao L.   +9 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Genome-wide fine-mapping improves identification of causal variants. [PDF]

Nat Genet
Wu Y, Zheng Z, Thibaut L, Lin T, Feng Q, Cheng H, Yengo L, Goddard ME, Wray NR, Visscher PM, Zeng J.   +10 more
europepmc   +1 more source