Results 161 to 170 of about 781,258 (217)

Integrative gene duplication and genome-wide analysis characterize Peroxin11 gene family in wheat. [PDF]

BMC Genomics
Ebeed HT.
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Genome-wide analysis of the ALDH superfamily in <i>Castanea mollissima</i> highlights roles in abiotic stress responses. [PDF]

Front Plant Sci
Wang X, Zhang T, Tian Y, Wang J, Liu X, Zhang G, Wang D, Zhang H, Yu L.   +8 more
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Genome‑wide analysis of the CaWRKY transcription factors reveals CaWRKY28 as a candidate gene for cold tolerance breeding in Coffea arabica L. [PDF]

BMC Plant Biol
Hu T, Zhang Z, Lan Y, Yang T, He F, Gao J, Dong X.   +6 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Genome-Wide Analysis Identifies <i>ScTCP6</i> as a Stress Responsive Gene in Rye. [PDF]

Curr Issues Mol Biol
Ren Y, Ma R, Wang Z, Li L, Xie M, Jiang T, Zhang J, Lian Q.   +7 more
europepmc   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Genome-wide analysis of inbreeding patterns and candidate genes for adaptation in indigenous chickens of Botswana. [PDF]

Poult Sci
Machete JB, Chalebgwa AB, Monau PI, Kgwatalala PM, Moreki J, Nsoso SJ.   +5 more
europepmc   +1 more source