Results 221 to 230 of about 732,792 (264)

Genome-Wide Analysis of Planarian piRNAs

2023
In planarian flatworms, the piRNA pathway is operated by three PIWI proteins, termed SMEDWI-1, SMEDWI-2, and SMEDWI-3 (SMEDWI = Schmidtea mediterranea PIWI). The interplay between these three PIWI proteins and their associated small noncoding RNAs, termed piRNAs, fuels the outstanding regenerative abilities of planarians, enables tissue homeostasis ...
Andreas, Pittroff, Iana V, Kim, Tim, Demtröder, Claus-D, Kuhn   +3 more
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Genome-Wide Functional Analysis

Science's STKE, 2004
An RNA interference-based screen on a genome-wide scale is likely to become one of the methods of choice for comprehensive functional genomic analysis because of its potential to identify, rapidly and systematically, genes that control a variety of cellular processes. Boutros et al. conducted such a screen of the
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Genome-wide Analysis of Myelodysplastic Syndromes

Current Pharmaceutical Design, 2012
Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic neoplasms characterized by ineffective hematopoiesis and a risk for progression to acute myeloid leukemia. A number of cytogenetic changes have been described that are characteristic to MDS and of clinical relevance; the specific gene targets of these alterations were largely unknown.
Masashi, Sanada, Seishi, Ogawa
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Genome-Wide Association Analysis Using R

2017
This chapter provides a practical overview of the statistical analysis using R [1] and genotype by sequencing (GBS) markers for genome-wide association studies (GWAS) in oats. Statistical analysis is performed by R package rrBLUP [2] and issues associated with the analysis are addressed along with the R code.
Julio, Isidro-Sánchez, Deniz, Akdemir, Gracia, Montilla-Bascón   +2 more
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Genome-wide analysis of HDAC function

Trends in Genetics, 2005
This article focuses on new developments in the genome-wide analysis of histone deacetylase (HDAC) function in yeast. HDACs are highly conserved in many organisms; therefore, their basic functions can be investigated using experimentally tractable model organisms, such as the budding yeast Saccharomyces cerevisiae and the fission yeast ...
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Genome-Wide Analysis of Yeast Aging

2011
In the past several decades the budding yeast Saccharomyces cerevisiae has emerged as a prominent model for aging research. The creation of a single-gene deletion collection covering the majority of open reading frames in the yeast genome and advances in genomic technologies have opened yeast research to genome-scale screens for a variety of phenotypes.
George L, Sutphin, Brady A, Olsen, Brian K, Kennedy, Matt, Kaeberlein   +3 more
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Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis

Molecular Biology Reports, 2012
The aims of this study were to identify candidate single nucleotide polymorphisms (SNPs) and mechanisms of multiple sclerosis (MS) and to generate SNP to gene to pathway hypotheses. A MS genome-wide association study (GWAS) dataset that included 505,763 SNPs in 500 cases and 500 controls of European descent was used in this study.
Gwan Gyu, Song, Sung Jae, Choi, Jong Dae, Ji, Young Ho, Lee   +3 more
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Genome-wide pathway analysis of a genome-wide association study on Alzheimer’s disease

Neurological Sciences, 2014
The aims of this study were to identify candidate single nucleotide polymorphisms (SNPs) and mechanisms of Alzheimer's disease (AD) and to generate SNP to gene to pathway hypotheses. An AD genome-wide association study (GWAS) dataset that included 370,542 SNPs in 1,000 cases and 1,000 controls of European descent was used in this study.
Young Ho, Lee, Gwan Gyu, Song
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Genome-Wide Proximal Promoter Analysis and Interpretation

2009
High-throughput gene expression technologies based on DNA microarrays allow the examination of biological systems. However, the interpretation of the complex molecular descriptions generated by these approaches is still challenging. The development of new methodologies to identify common regulatory mechanisms involved in the control of the expression ...
Corrales, F.J. (Fernando José), Guruceaga, E. (Elizabeth), Segura, V. (Víctor), Rubio, A. (Ángel)   +3 more
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Genome-wide analysis of signaling domain function

Current Opinion in Chemical Biology, 2003
Approximately 2.5% of human gene products contain one or more small domains that drive interactions between proteins and other cellular components in cell signaling processes. The many interactions driven by these relatively simple domains are thought to cooperate with one another to yield complex signaling networks that allow very fine control of cell
Jong W, Yu, Mark A, Lemmon
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