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Genome-Wide Functional Analysis
Science's STKE, 2004An RNA interference-based screen on a genome-wide scale is likely to become one of the methods of choice for comprehensive functional genomic analysis because of its potential to identify, rapidly and systematically, genes that control a variety of cellular processes. Boutros et al. conducted such a screen of the
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Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet’s disease
Molecular Biology Reports, 2011The aim of this study was to identify candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms of psoriasis and Behcets's disease (BD) and to generate an SNP → gene → pathway hypothesis. A psoriasis genome-wide association study (GWAS) dataset that included 436,192 SNPs in 1,409 psoriasis cases and 1,436 controls of ...
Young Ho, Lee +3 more
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Meta-Analysis of Genome-Wide Association Studies
Cold Spring Harbor Protocols, 2010INTRODUCTIONIndividual genome-wide association studies have only limited power to find novel loci underlying complex traits and common diseases. With relatively modest sample and effect sizes, a true association between genotype and phenotype may never meet genome-wide statistical significance (P < 5 × 10-8) in a single study. Through meta-analysis,
Paul I W, de Bakker +2 more
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Advancing the use of genome-wide association studies for drug repurposing
Nature Reviews Genetics, 2021William Reay +2 more
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Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine
Nature Reviews Drug Discovery, 2016Kathleen M Giacomini +2 more
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Analysing biological pathways in genome-wide association studies
Nature Reviews Genetics, 2010, Hakon Hakonarson, Li Mingyao
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Genotype imputation for genome-wide association studies
Nature Reviews Genetics, 2010Jonathan Marchini +2 more
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