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Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet’s disease
Molecular Biology Reports, 2011The aim of this study was to identify candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms of psoriasis and Behcets's disease (BD) and to generate an SNP → gene → pathway hypothesis. A psoriasis genome-wide association study (GWAS) dataset that included 436,192 SNPs in 1,409 psoriasis cases and 1,436 controls of ...
Young Ho, Lee +3 more
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Genome-Wide Functional Analysis
Science's STKE, 2004An RNA interference-based screen on a genome-wide scale is likely to become one of the methods of choice for comprehensive functional genomic analysis because of its potential to identify, rapidly and systematically, genes that control a variety of cellular processes. Boutros et al. conducted such a screen of the
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Meta-Analysis of Genome-Wide Association Studies
Cold Spring Harbor Protocols, 2010INTRODUCTIONIndividual genome-wide association studies have only limited power to find novel loci underlying complex traits and common diseases. With relatively modest sample and effect sizes, a true association between genotype and phenotype may never meet genome-wide statistical significance (P < 5 × 10-8) in a single study. Through meta-analysis,
Paul I W, de Bakker +2 more
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Tuning ReliefF for Genome-Wide Genetic Analysis
2007An important goal of human genetics is the identification of DNA sequence variations that are predictive of who is at risk for various common diseases. The focus of the present study is on the challenge of detecting and characterizing nonlinear attribute interactions or dependencies in the context of a genome-wide genetic study.
Jason H. Moore, Bill C. White
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Advancing the use of genome-wide association studies for drug repurposing
Nature Reviews Genetics, 2021William R Reay +2 more
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Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine
Nature Reviews Drug Discovery, 2016Kathleen M Giacomini +2 more
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Methods for Genome-Wide Chromatin Interaction Analysis
Recent analyses revealed the essential function of chromatin structure in maintaining and regulating genomic information. Advancements in microscopy, nuclear structure observation techniques, and the development of methods utilizing next-generation sequencers (NGSs) have significantly progressed these discoveries.openaire +2 more sources
Analysing biological pathways in genome-wide association studies
Nature Reviews Genetics, 2010Mingyao Li +2 more
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