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Genome-wide analysis of HDAC function
Trends in Genetics, 2005This article focuses on new developments in the genome-wide analysis of histone deacetylase (HDAC) function in yeast. HDACs are highly conserved in many organisms; therefore, their basic functions can be investigated using experimentally tractable model organisms, such as the budding yeast Saccharomyces cerevisiae and the fission yeast ...
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Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis
Molecular Biology Reports, 2012The aims of this study were to identify candidate single nucleotide polymorphisms (SNPs) and mechanisms of multiple sclerosis (MS) and to generate SNP to gene to pathway hypotheses. A MS genome-wide association study (GWAS) dataset that included 505,763 SNPs in 500 cases and 500 controls of European descent was used in this study.
Gwan Gyu, Song +3 more
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Genome‐Wide Analysis of Epigenetics in Cancer
Annals of the New York Academy of Sciences, 2003Abstract: Human cancers are caused by multiple mechanisms. Research in the last 30 years has firmly established the roles of a group of genes including oncogenes, tumor suppressor genes, and DNA repair genes in human cancers. The activation and inactivation of these cancer genes can be caused by genetic mutations or epigenetic alterations.
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Analysis of Genome-Wide Association Data
2016The last decade has seen substantial advances in the understanding of the genetics of complex traits and disease. This has been largely driven by genome-wide association studies (GWAS), which have identified thousands of genetic loci associated with these traits and disease.
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Genome-Wide Analysis of Yeast Aging
2011In the past several decades the budding yeast Saccharomyces cerevisiae has emerged as a prominent model for aging research. The creation of a single-gene deletion collection covering the majority of open reading frames in the yeast genome and advances in genomic technologies have opened yeast research to genome-scale screens for a variety of phenotypes.
George L, Sutphin +3 more
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Genome-Wide Analysis of Epigenetic Modifications
Journal of Computer Science and Technology, 2010In plants and animals, gene expression can be altered by changes that do not alter the sequence of nucleotides in DNA but rather modify the chemical structure of either the DNA or the histones that interact with the DNA. These so-called epigenetic modifications are not transient, but persist through cell divisions.
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Analysis of Genome-Wide Association Studies
Genome-wide association studies (GWAS) aim to identify genetic variants across the whole genome associated with the phenotype of interest. This technique has been largely used in the bone field to elucidate the genetic architecture of complex traits, like bone mineral density or fracture risk, and to date, more than 600 loci have been identified.Piyush, Gampawar +2 more
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Methylated DNA Immunoprecipitation Genome-Wide Analysis
2011DNA methylation is an important and potentially heritable component of the epigenetic machinery that has a major role in the control of gene expression and can be deregulated in many diseases. This modification of genomic DNA can be assessed using the methylated DNA immunoprecipitation (MeDIP) method, based on the quantification of methylated DNA ...
Pelizzola M, Molinaro A
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A platform for genome-wide analysis
2011 IEEE International Symposium on IT in Medicine and Education, 2011By integrating most tools and websites of genome-wide analysis, a platform has been developed to provide simple sequences analysis for researchers to teach and independently study. Presently, more and more researchers focus their attention on genetic area, yet it is still challenging for biomedical researchers to access and analyze the exponentially ...
null Xuan Si +3 more
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Genome-Wide Proximal Promoter Analysis and Interpretation
2009High-throughput gene expression technologies based on DNA microarrays allow the examination of biological systems. However, the interpretation of the complex molecular descriptions generated by these approaches is still challenging. The development of new methodologies to identify common regulatory mechanisms involved in the control of the expression ...
Corrales, F.J. (Fernando José) +3 more
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