Results 211 to 220 of about 25,267,477 (304)

Genome-wide analysis of strand-specific transcription and DNA methylation in <i>Plasmodium falciparum</i> severe malaria. [PDF]

Front Microbiol
Gujarati S, Singal BR, Majumder S, Kochar SK, Kochar DK, Das A.   +5 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Systematic Druggable Genome-Wide Analysis Identifies Therapeutic Targets for Aging: A Mendelian Randomization Study. [PDF]

Health Sci Rep
Zhang Y, Wang M, Li H, Jin T, Peng S, Dong Y, Deng C, Li H, Li X, Qin J, Ye X.   +10 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

TEGS-CN: A Statistical Method for Pathway Analysis of Genome-wide Copy Number Profile

Cancer Informatics, 2014
Yen-Tsung Huang, Thomas Hsu, David C. Christiani   +2 more
doaj  

Identification of specific transcripts for plant heat stress tolerance through genome-wide analysis of SIZ1-dependent alternative polyadenylation. [PDF]

Stress Biol
Wang J, Wu X, Zhou Z, Zheng S, Hu M, Xiao Y, Shi L, Zhang C, Li J, Yang C, Lai J, Han D, Yu Z.   +12 more
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

A genome-wide analysis of YUCCA genes in cotton and the functional study of GhYUC19 in plant development. [PDF]

BMC Plant Biol
Zhong W, Aminu IM, Zhang Y, Zhu S, Yao J, Li Y, Pan J, Chen W, Rong J.   +8 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Genome-wide analysis reveals ligand-dependent allostery in RARα:RXR-mediated transcriptional regulation. [PDF]

Cell Rep
Hawkins CL, Blaner WS, Fernandez EJ.
europepmc   +1 more source