Results 51 to 60 of about 732,792 (264)

Genome wide in silico SNP-tumor association analysis

BMC Cancer, 2004
Background Carcinogenesis occurs, at least in part, due to the accumulation of mutations in critical genes that control the mechanisms of cell proliferation, differentiation and death.
Simon Jason S, Ding Wei, Kostich Mitch, Wang Luquan, Qiu Ping, Greene Jonathan R   +5 more
doaj  

Genome wide SNP discovery, analysis and evaluation in mallard (Anas platyrhynchos)

BMC Genomics, 2011
Background Next generation sequencing technologies allow to obtain at low cost the genomic sequence information that currently lacks for most economically and ecologically important organisms. For the mallard duck genomic data is limited. The mallard is,
Huang Yinhua, Vignal Alain, Elmberg Johan, Van Der Poel Jan J, Crooijmans Richard PMA, Van Hooft Pim, Kerstens Hindrik HD, Kraus Robert HS, Li Ning, Prins Herbert HT, Groenen Martien AM   +10 more
doaj   +1 more source

Genome-wide polygenic analysis of multiple sclerosis markers

Неврология, нейропсихиатрия, психосоматика, 2021
Objective: to perform a genome-wide polygenic analysis of multiple sclerosis (MS) markers in the ethnic groups of Bashkirs, Russians, and Tatars living in the Republic of Bashkortostan (Russian Federation).Patients and methods.
Ya. R. Timasheva, T. R. Nasibullin, I. A. Tuktarova, V. V. Erdman, T. R. Galiullin, O. V. Zaplakhova, K. Z. Bakhtiiarova   +6 more
doaj   +1 more source

Genome-wide pathway analysis in glioma

Neoplasma, 2015
The aim of this study was to identify candidate single-nucleotide polymorphisms (SNPs) that may play a role in the susceptibility to glioma, to elucidate their potential mechanisms, and to generate SNP-to-gene-to-pathway hypotheses.A genome-wide association study (GWAS) dataset of glioma including 509,345 SNPs from 1,856 glioma patients and 4,955 ...
Y H, Lee, G G, Song
openaire   +3 more sources

Genome-wide comprehensive analysis of human helicases [PDF]

Communicative & Integrative Biology, 2011
Helicases are motor proteins that catalyze the unwinding of duplex nucleic acids in an ATP-dependent manner. They are involved in almost all the nucleic acid transactions. In the present study, we report a comprehensive analysis of helicase gene family in human and its comparison with homologs in model organisms.
Pavan, Umate, Narendra, Tuteja, Renu, Tuteja   +2 more
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Genome-wide meta-analysis identifies novel loci associated with parathyroid hormone level

Molecular Medicine, 2018
Background Parathyroid hormone (PTH) is one of the principal regulators of calcium homeostasis. Although serum PTH level is mostly accounted by genetic factors, genetic background underlying PTH level is insufficiently known.
Antonela Matana, Dubravka Brdar, Vesela Torlak, Thibaud Boutin, Marijana Popović, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Ozren Polašek, Maja Barbalić, Caroline Hayward, Tatijana Zemunik   +12 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Genome‐Wide Association Analysis Identifies LILRB2 Gene for Pathological Myopia

Advanced Science
Pathological myopia (PM) is one of the leading causes of blindness, especially in Asia. To identify the genetic risk factors of PM, a two‐stage genome‐wide association study (GWAS) and replication analysis in East Asian populations is conducted.
Lingxi Jiang, Lulin Huang, Chao Dai, Rui Zheng, Masahiro Miyake, Yuki Mori, Shin‐ya Nakao, Kazuya Morino, Kenji Ymashiro, Yang‐Bao Miao, Qi Li, Weiming Ren, Zimeng Ye, Hongjing Li, Zhenglin Yang, Yi Shi   +15 more
doaj   +1 more source