Results 31 to 40 of about 49,899 (262)
Pathway analysis comparison using Crohn's disease genome wide association studies
BMC Medical Genomics, 2010 Background The use of biological annotation such as genes and pathways in the analysis of gene expression data has aided the identification of genes for follow-up studies and suggested functional information to uncharacterized genes. Several studies have
Cho Judy +3 more
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
SuperDCA for genome-wide epistasis analysis
Microbial Genomics, 2017 The potential for genome-wide modelling of epistasis has recently surfaced given the possibility of sequencing densely sampled populations and the emerging families of statistical interaction models. Direct coupling analysis (DCA) has previously been shown to yield valuable predictions for single protein structures, and has ...
Pesonen, Maiju +8 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Functional analysis of glial genome-wide expression
Frontiers in Cellular Neuroscience, 2015 Modern neurosciences have benefited from the recent development of high-throughput experimental platforms that allow the parallel analysis of thousands of molecules or regions of interest.
Diego Forero
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Genome-Wide Transcriptome Analysis in Type 2 Diabetes Patients Treated by Sitagliptin
Diabetes, Metabolic Syndrome and Obesity, 2022 Rui Ma,1 Xiao-long Deng,2 Qi-qi-ge Aleteng,1 Lei Li,1 Jun Zhu3 1Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, People’s Republic of China; 2Department of Endocrinology, Shunde Hospital
Ma R, Deng X, Aleteng Q, Li L, Zhu J
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Genome wide association analysis in a mouse advanced intercross line
Nature Communications, 2018 Multigenerational outbred populations from an advanced intercross line (AIL) of mice represent useful resources for genome wide association analysis.
Natalia M. Gonzales +9 more
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Power analysis for genome-wide association studies
BMC Genetics, 2007 Background Genome-wide association studies are a promising new tool for deciphering the genetics of complex diseases. To choose the proper sample size and genotyping platform for such studies, power calculations that take into account genetic model, tag ...
Klein Robert J
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