Results 31 to 40 of about 754,015 (260)

Approximate conditional phenotype analysis based on genome wide association summary statistics

Scientific Reports, 2021
Because single genetic variants may have pleiotropic effects, one trait can be a confounder in a genome-wide association study (GWAS) that aims to identify loci associated with another trait.
Peitao Wu, Biqi Wang, Steven A. Lubitz, Emelia J. Benjamin, James B. Meigs, Josée Dupuis   +5 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Pathway analysis comparison using Crohn's disease genome wide association studies

BMC Medical Genomics, 2010
Background The use of biological annotation such as genes and pathways in the analysis of gene expression data has aided the identification of genes for follow-up studies and suggested functional information to uncharacterized genes. Several studies have
Cho Judy, Abraham Clara, Ballard David, Zhao Hongyu   +3 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

SuperDCA for genome-wide epistasis analysis

Microbial Genomics, 2017
The potential for genome-wide modelling of epistasis has recently surfaced given the possibility of sequencing densely sampled populations and the emerging families of statistical interaction models. Direct coupling analysis (DCA) has previously been shown to yield valuable predictions for single protein structures, and has ...
Pesonen, Maiju, Pensar, Johan, Xu, Yingying, Lees, John A., Bentley, Stephen, Croucher, Nicholas J, Corander, Jukka, Puranen, Santeri   +8 more
openaire   +4 more sources

Genome-wide analysis of mutually exclusive splicing [PDF]

, 2022
In recent years, advances in sequencing techniques resulted in an explosive increase in sequencing data. Here, computational methods and bioinformatical analyses are presented that provide approaches to keep pace with the growing amount of data. In the post-genomic era, an important step to derive knowledge from sequence information is to find protein ...
Hatje, Klas, Kollmar, Martin, Kollmar, Martin, Georg-August-Universität Göttingen, Kollmar, Martin, Morgenstern, Burkhard   +5 more
openaire   +3 more sources

Functional analysis of glial genome-wide expression

Frontiers in Cellular Neuroscience, 2015
Modern neurosciences have benefited from the recent development of high-throughput experimental platforms that allow the parallel analysis of thousands of molecules or regions of interest.
Diego Forero
doaj   +1 more source

Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341‐Associated Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver, Dyanne Rampling, Barbara Walkowiak, Nathaniel D. Anderson, Manas Dave, Henry Lee‐Six, Sadie Baskind, Pooja Balasubramanian, Glenn Anderson, Conor Parks, Toochi Ogbonnah, Emilia R. Robertson, Simon Hannam, Rohan Verma, John C. Achermann, Liina Palm, Neil Sebire, Thomas Jacques, Tom Watson, Carryl Dryden, Karin Straathof, Mette Jorgensen, Olga Slater, Sam Behjati, Sarita Depani, J. Ciaran Hutchinson   +25 more
wiley   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Genome-Wide Transcriptome Analysis in Type 2 Diabetes Patients Treated by Sitagliptin

Diabetes, Metabolic Syndrome and Obesity, 2022
Rui Ma,1 Xiao-long Deng,2 Qi-qi-ge Aleteng,1 Lei Li,1 Jun Zhu3 1Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, People’s Republic of China; 2Department of Endocrinology, Shunde Hospital
Ma R, Deng X, Aleteng Q, Li L, Zhu J
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