Results 51 to 60 of about 25,155,128 (260)

Genome wide association analysis in a mouse advanced intercross line

Nature Communications, 2018
Multigenerational outbred populations from an advanced intercross line (AIL) of mice represent useful resources for genome wide association analysis.
Natalia M. Gonzales, Jungkyun Seo, Ana I. Hernandez Cordero, Celine L. St. Pierre, Jennifer S. Gregory, Margaret G. Distler, Mark Abney, Stefan Canzar, Arimantas Lionikas, Abraham A. Palmer   +9 more
doaj   +1 more source

Power analysis for genome-wide association studies

BMC Genetics, 2007
Background Genome-wide association studies are a promising new tool for deciphering the genetics of complex diseases. To choose the proper sample size and genotyping platform for such studies, power calculations that take into account genetic model, tag ...
Klein Robert J
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA [PDF]

, 2012
Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.
Palmer Cameron D., Marjo-Riitta Jarvelin, Coin, Lachlan, Matthew A. Brown (131482), Ferreira, Manuel, O'Connor, George T, Guy B Marks, Dharmage, Shyamali C, Adaikalavan Ramasamy (4841), Anneli Pouta, Lehtimäki Terho, Tari Haahtela, Veikko Salomaa (62543), Shyamali C. Dharmage, Manuel A R Ferreira, Lehtimaki, Terho, Anneli Pouta (116626), Pekkanen Juha, Joel N Hirschhorn, Gajdos, Zofia K, Strachan David P., Palotie Aarno, Colin F. Robertson (131511), Philip J Thompson, Lehtimäki, T, Montgomery, Grant, Andrew C. Heath, Duffy David L., Strachan, David P, Elisabeth Widen (75580), Matthias Wjst (56613), Thompson, Philip, David L. Duffy (131489), Martin, Nicholas G., Laitinen, Tarja, Hirschhorn, Joel, Raitakari, Olli T, Alexessander Couto Alves, Tarja Laitinen, Lyon, Helen, Wareham, Nick, Laitinen Tarja, Palmer, CD, Raitakari Olli T., Peter Le Souef, Christer Janson, Vedantam, Sailaja, Janson Christer, Sailaja Vedantam (131467), George T. O'Connor (110263), Marks Guy B., Ramasamy, Adaikalavan, Ferreira, Manuel AR, Andrew C Heath, Peter Le Souef (131503), David P Strachan, Palotie, Aarno, Eriksson, Johan, Jing Hua Zhao (73808), Jorma Viikari, Tari Haahtela (131492), Nick Wareham, Grant W. Montgomery (131518), Heathe, Andrew C, Khaw, KT, Nicholas G. Martin (113568), Jarvelin, Marjo-Riitta, Robertson, CF, Mika Kähönen (131499), Michael J. Abramson, Matheson, M C, Kay-Tee Khaw, Pouta, Anneli, David P. Strachan, Abramson, Michael J, Manuel A. R. Ferreira, Aarno Palotie (41342), Juha Pekkanen (27303), Palotie, A, Mikko Kuokkanen, Ferreira, MA, Marks, Guy B., Helen N Lyon, Philip J. Thompson (131523), Cameron D Palmer, Deborah L. Jarvis (131514), Thompson, Philip J., Colin F. Robertson, Janson, Christer,, Heath, Andrew C, Madden, Pamela AF, Kuokkanen Mikko, Strachan, David P., Salomaa, Veikko, Jaana Laitinen (116629), Coin, L, Haahtela, T, Widen Elisabeth, Ramasamy, A, Martin, NG, Janson, C, Madden, PA, Eriksson, J, Laitinen Jaana, Thompson Philip J., Couto Alves, A, Matheson, Melanie C, Australian Asthma Genetics, Martin Nicholas G., ?, ?, Salomaa, V, Zhao, Jing Hua, Olli T Raitakari, Palmer, Cameron D, David L Duffy, Jarvis Deborah L., Palmer, Cameron, Widen, Elizabeth, Zofia K. Gajdos (131468), Matheson, Melanie C., Widen, Elisabeth, O'Connor George T., Martin, Nicholas, Raitakari, OT, O'Connor, George, Kähönen Mika, Colin F Robertson, O'Connor, GT, Kähönen, M, Gajdos, Zofia, Duffy, David L., Lachlan Coin (3863), Jarvelin Marjo-Riitta, Dharmage Shyamali C., Dharmage, Shyamali C., Raitakari, Olli T., Jousilahti, P, Hirschhorn Joel N., Pekka Jousilahti, Ferreira Manuel A. R., Lyon, Helen N., Guy B. Marks (116572), Martin, Nicholas G, Nicholas G Martin, Brown, MA, Marks, Guy, Michael J. Abramson (131480), Pekkanen, Juha, Lyon, HN, Matheson Melanie C., Pekkanen, J, Madden Pamela A. F., Duffy, DL, Heath, AC, Gajdos Zofia K., Olli T. Raitakari (115559), Lachlan Coin, Lyon, Helen N, Camerond Palmer, Nicholas G. Martin, Strachan, David, Jousilahti Pekka, Jousilahti, Pekka, Dharmage, Shyamali, Pamela A. F. Madden (127156), Veikko Salomaa, Madden, Pamela, Wjst Matthias, Zofia K. Gajdos, Marks, GB, Matthew A Brown, Manuel A. R. Ferreira (131476), Khaw, Kay-Tee, Jarvis, Deborah L., Kahonen, Mika, Montgomery, GW, Montgomery, Grant W, Eriksson Johan, Pouta, A, Viikari, J, Heath Andrew C., Johan Eriksson, Shyamali C. Dharmage (131486), Laitinen, T, Laitinen, J, Johan Eriksson (131534), Pekka Jousilahti (131538), David L. Duffy, Palmer, Cameron D., Palmer, Cameron Douglas, George T O'Connor, Duffy, David, Viikari, E, Jaana Laitinen, Kay-Tee Khaw (110271), Viikari Jorma, Matheson, MC, Mikko Kuokkanen (131465), Khaw Kay-Tee, Matthew A. Brown, Thompson, Philip J, Montgomery Grant W., Le Souef, P, Robertson, Colin, Jarvis, Debbie, Mika Kähönen, Pamela A F Madden, Melanie C Matheson, Pouta Anneli, Alexessander Couto Alves (131470), Andrew C. Heath (127152), Tarja Laitinen (131542), George T. O’connor, Viikari, Jorma, Aarno Palotie, O'Connor, George T., Melanie C. Matheson (131507), Lyon Helen N., Marks, Guy B, Joel N. Hirschhorn, Ramasamy Adaikalavan, Terho Lehtimäki (49739), Juha Pekkanen, Marjo-Riitta Jarvelin (110290), Heathe, Andrew, Abramson Michael J., Heath, Andrew C., Wareham Nick, Gajdos, ZK, Zhao, Jing, Brown, Matthew A, Deborah L. Jarvis, Matheson, M, Abramson, Michael, Michael J Abramson, Christer Janson (83414), Jarvelin, MR, Adaikalavan Ramasamy, Duffy, David L, Jing Hua Zhao, Zhao Jing Hua, Jorma Viikari (49741), Montgomery, Grant W., Brown, Matthew A., Vedantam Sailaja, Robertson Colin F., Wjst, Matthias, Cameron D. Palmer (131509), David P. Strachan (110302), Hirschhorn, Joel N., Ferreira, Manuel A. R., Er Couto Alves, Thompson, PJ, Raitakari, Olli, Brown, Matthew, Laitinen, Jaana, Haahtela Tari, Grant W Montgomery, Brown Matthew A., Alves, Alexessander Couto, Robertson, Colin F., Matthias Wjst, Olli T. Raitakari, Zhao, JH, Couto Alves, Alexessander, Shyamali C Dharmage, Melanie C. Matheson, Gajdos, Zofia K., Kuokkanen, M, Widen, E, Hirschhorn, Joel N, Salomaa Veikko, Deborah L Jarvis, Janson, Christer, Guyb. Marks, Le Souef, Peter, Le Souef Peter, Wareham, N, Haahtela, Tari, Kuokkanen, Mikko, Hirschhorn, JN, Vedantam, S, Dharmage, SC, Jarvis, DL, Jarvis, Deborah L, Couto Alves Alexessander, Strachan, DP, Nick Wareham (131528), Pamela A. F. Madden, Abramson, MJ, Coin Lachlan, Elisabeth Widen, Madden, Pamela A, Zofia K Gajdos, Wjst, M, Sailaja Vedantam, Grant W. Montgomery, Robertson, Colin F, Philip J. Thompson, Helen N. Lyon (131473), Australian Asthma Genetics Consortium Collaborators, Abramson, Michael J., Joel N. Hirschhorn (131545), Terho Lehtimäki, Helen N. Lyon, Madden, Pamela A. F., Strachan, D. P., Jousilahti, P., Raitakari, O. T., Thompson, P. J., Lehtimäki, T., Salomaa, V., Dharmage, S. C., Montgomery, G. W., Widen, E., Gajdos, Z. K., O'Connor, G. T., Couto Alves, A., Eriksson, J., Laitinen, T., Vedantam, S., Haahtela, T., Heath, A. C., et al,, et al., Pouta, A., Hirschhorn, J. N., Abramson, M. J., Palotie, A., Duffy, D. L., Viikari, J., Jarvelin, M. R., Kähönen, M., Brown, Matthew. A., Wjst, M., Kuokkanen, M., Coin, L., Lyon, H. N., Matheson, M. C., Palmer, C. D., Khaw, K. T., Ferreira, M. A. R., Le Souef, P., Martin, N. G., Robertson, C. F., Wareham, N., Janson, C., Pekkanen, J., Madden, P. A. F., Zhao, J. H., Jarvis, D. L., Laitinen, J., Marks, G. B., Ramasamy, A.   +353 more
core   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]

, 2009
OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...
Timpson, NJ, David P. Strachan, Weedon, Michael N., Weedon, MN, Nicholas J. Timpson, Rayner, NW, Morris, Andrew D., Zeggini, Eleftheria, Mark Walker, Alex S.F. Doney, Doney, ASF, Palmer, Colin N A, Timothy M. Frayling, Strachan, David P., Hitman, Graham A., Lindgren, Cecilia M., Hattersley, Andrew T., Hitman, GA, Lindgren, CM, Randall, Joshua, Doney, Alex S. F.; id_orcid, Graham A. Hitman, Andrew T. Hattersley, Walker, Mark, Palmer, CN, Hattersley, AT, Rayner, N. William, McCarthy, MI, Timpson, Nicholas J., Michael N. Weedon, Willem H. Ouwehand, Palmer, CNA, Walker, M, Andrew D. Morris, Doney, Alex S F, N. William Rayner, Lindgren, Cecilia, Randall, J, Mark I. McCarthy, Frayling, Timothy M., Strachan, DP, Morris, AD, Cecilia M. Lindgren, Doney, AS, Joshua Randall, McCarthy, Mark I., Zeggini, E, Eleftheria Zeggini, Ouwehand, WH, Pamler, CAN, Ouwehand, Willem H., Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +53 more
core   +1 more source

Assigning function to genome wide association study variants associated with complex gastrointestinal disease [PDF]

, 2009
PhDThe genome‐wide association study era has identified numerous loci associated with many common polygenic diseases. The next challenge is to identify the functional consequences of these variants and elicit how they impact on disease risk.
Heap, Graham Alastair Richard
core   +4 more sources

Genome wide in silico SNP-tumor association analysis

BMC Cancer, 2004
Background Carcinogenesis occurs, at least in part, due to the accumulation of mutations in critical genes that control the mechanisms of cell proliferation, differentiation and death.
Simon Jason S, Ding Wei, Kostich Mitch, Wang Luquan, Qiu Ping, Greene Jonathan R   +5 more
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Genome-wide association pathway analysis to identify candidate single nucleotide polymorphisms and molecular pathways associated with TP53 expression status in HBV-related hepatocellular carcinoma

Cancer Management and Research, 2018
Xiwen Liao,1,* Long Yu,1,* Xiaoguang Liu,1,2 Chuangye Han,1 Tingdong Yu,1 Wei Qin,1 Chengkun Yang,1 Guangzhi Zhu,1 Hao Su,1 Tao Peng1 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’
Liao X, Yu L, Liu X, Han C, Yu T, Qin W, Yang C, Zhu G, Su H, Peng T   +9 more
doaj