Results 41 to 50 of about 25,155,128 (260)

Pathway analysis comparison using Crohn's disease genome wide association studies

BMC Medical Genomics, 2010
Background The use of biological annotation such as genes and pathways in the analysis of gene expression data has aided the identification of genes for follow-up studies and suggested functional information to uncharacterized genes. Several studies have
Cho Judy, Abraham Clara, Ballard David, Zhao Hongyu   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

, 2011
To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-
Richard W. Morris, Kumari, Meena, Hardy, R, Berry, Diane J, Cooper, Jackie, Ulf de Faire, Angelakopoulou, A, Jutta Palmen, de Faire, Ulf, Tzoulaki, I, Fowkes, F. Gerry R., Marmot, Michael, Samani, Nilesh, Price, Jackie; id_orcid, Andrew Wong, Wong, A, Munroe, Patricia B, Kumari, M, Shah, T, Jefferis, BJ, Deanfield, John, Simpson, Iain A., Simpson, Iain A, Shah, S, Juan P. Casas, Thomson, Andy, Jefferis, Barbara J., Samani, N, Whittaker, John C, Bruna Gigante, Philippa J. Talmud, Lathrop, Mark, Munroe, Patricia B., John C. Whittaker, Drenos, F, Motterle, Anna, John Deanfield, F. Gerry R. Fowkes, Helen Ireland, Shu Ye, Price, J, Whincup, PH, Steve E. Humphries, Verzilli, C, Kivimaki, Mika, Power, C, Leander, Karin, Sofat, R, Jackie Price, Hypponen, Elina, Caulfield, Mark, Humphries, Steve E, Tina Shah, Anna Motterle, Kuh, Diana, Jefferis, Barbara J, Gigante, B, Maniatis, Nikolas, Whincup, Peter H, Casas, Juan P, Palmen, J, Diana Kuh, Shah, Sonia, Liam Smeeth, Gigante, Bruna, Ireland, Helen, Price, Jackie, Thomson, A, Elina Hypponen, Verzilli, Claudio, Nikolas Maniatis, Smeeth, Liam, Casas, JP, Angelakopoulou, Aspasia, Marmot, M, Ross C. Laxton, Munroe, PB, Barbara J. Jefferis, Cooper, J, Wallace, C, Simpson, IA, Caulfield, M, Talmud, PJ, Andy Thomson, Laxton, Ross C., Drenos, Fotios, Morris, Richard W, Iain A. Simpson, Chris Wallace, Mika Kivimaki, Lathrop, M, Humphries, SE, Motterle, A, Hingorani, AD, de Faire, U, Whittaker, JC, Meena Kumari, Jackie Cooper, Laxton, Ross C, Ioanna Tzoulaki, Claudio Verzilli, Ye, S, Wallace, Chris, Sonia Shah, Hardy, Rebecca, Shah, Tina, Aspasia Angelakopoulou, Berry, DJ, Hingorani, Aroon D, Laxton, RC, Nilesh Samani, Hypponen, E, Fowkes, F Gerry R, Morris, RW, Diane J. Berry, Rebecca Hardy, Maniatis, N, Mark Lathrop, Fowkes, FG, Reecha Sofat, Tzoulaki, Ioanna, Chris Power, Michael Marmot, Leander, K, Power, Chris, Smeeth, L, Mark Caulfield, Ye, Shu, Sofat, Reecha, Ireland, H, Fotios Drenos, Talmud, Philippa J, Kuh, D, Deanfield, J, Kivimaki, M, Wong, Andrew, Peter H. Whincup, Patricia B. Munroe, Berry, Diane J., Karin Leander, Palmen, Jutta, Aroon D. Hingorani, Hingorani, A.D., Angelakopoulou, A., Hypponen, E., Sofat, R., Shah, S., Shah, T.   +147 more
core   +1 more source

Advances in genome-wide DNA methylation analysis

BioTechniques, 2010
The covalent DNA modification of cytosine at position 5 (5-methylcytosine; 5mC) has emerged as an important epigenetic mark most commonly present in the context of CpG dinucleotides in mammalian cells.
Romi Gupta, Arvindhan Nagarajan, Narendra Wajapeyee   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Functional analysis of glial genome-wide expression

Frontiers in Cellular Neuroscience, 2015
Modern neurosciences have benefited from the recent development of high-throughput experimental platforms that allow the parallel analysis of thousands of molecules or regions of interest.
Diego Forero
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array [PDF]

, 2009
The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans.
Döring, Angela, Illig, T, Peeter Juhanson, Katrin Kepp, Juhanson, P., Juhanson, P, Samani, Nilesh, Philip Howard, Caulfield, Mark J., P. B. Munroe (7602386), Veldre, G, Farrall, Martin, Lichtner Peter, Dobson, RJ, Viigimaa, M., C. Gieger (7609259), Morris Brown, Putku Margus, Wichmann, H.-E., Illig, T., Siim Sõber, Gudrun Veldre, Shaw-Hawkins, Sue, Kelgo, Piret, Illig Thomas, R. J. Dobson (7602557), Samani, N, Samani Nilesh, Laan, Maris, HYPertens ESTonia Study, A. Dominiczak (7611551), Munroe, Patricia B., Kepp, K, John Connell, T. Illig (7609322), Samani, N., M. Putku (7602647), Viigimaa Margus, Farrall Martin, Brown, M, Peter Lichtner, Sober, S, A. Döring (7609562), Lichtner, Peter, P. Howard (7611350), Piret Kelgo, Juhanson Peeter, Dobson, Richard J.; id_orcid, Org, E, Farrall, M, Dobson, R.J., Meitinger, T, Veldre, Gudrun, E. Org (7602644), Kooperative Gesundheitsforschung in der Region Augsburg Study, Lichtner, P., H-Erich Wichmann, Martin Farrall, Kepp, Katrin, Gieger, Christian, HYPertension in ESTonia Study, Margus Putku, Newhouse, SJ, Onipinla Abiodun, Caulfield Mark J., Meitinger, T., M. Laan (7602659), Caulfield, MJ, Maris Laan, Eyheramendy, S., Onipinla, A., Newhouse, S.J., M. Viigimaa (7602620), Gieger, C, Dominiczak, A., Kelgo, P, Onipinla, A, Döring Angela, Newhouse, Stephen J.; id_orcid, Shaw-Hawkins Sue, Susana Eyheramendy, Munroe, PB, Klopp, Norman, Newhouse, Stephen J., Brown, Morris, Putku, Margus, M. Farrall (6522599), Wichmann, H.-Erich, Meitinger Thomas, S. Eyheramendy (7611197), Wichmann, Heinz-Erich, Putku, M, M. Brown (3020991), Gieger, C., Christian Gieger, Döring, A., Dobson, Richard J., Munroe, P.B., Juhanson, Peeter, Lichtner, P, Richard J Dobson, Org, E., H-E. Wichmann (7611602), Doering, Angela, Howard Philip, Kepp, K., Org, Elin, Kelgo Piret, Anna Dominiczak, Klopp, N., S. Shaw-Hawkins (7602380), Org Elin, Gieger Christian, Dominiczak Anna, Margus Viigimaa, Viigimaa, Margus, Newhouse Stephen J., K. Kepp (7611593), Sue Shaw-Hawkins, Stephen J Newhouse, Howard, P., Munroe Patricia B., Wichmann, H. Erich, P. Kelgo (7611596), Wichmann H.-Erich, Eyheramendy, S, Kooperative Gesundheitsforsch, Putku, M., M. J. Caulfield (7602383), Patricia B Munroe, Howard, P, Angela Döring, Eyheramendy, Susana, Nilesh Samani, Veldre Gudrun, Kepp Katrin, Sõber Siim, J. . Connell (7611608), Wichmann, HE, MRC British Genet Hypertens Study, Laan, M., Laan Maris, Elin Org, Connell, J, Illig, Thomas, Meitinger, Thomas, Doring, A, Viigimaa, M, Thomas Illig, N. Klopp (7611599), S. J. Newhouse (7602371), Connell John, S. Sõber (7602650), Shaw-Hawkins, S, Onipinla, Abiodun, Shaw-Hawkins, S., Dobson Richard J., Dominiczak, A, Klopp Norman, T. Meitinger (14191), Abiodun Onipinla, G. Veldre (7602656), Sõber, Siim, Thomas Meitinger, Eyheramendy Susana, P. Lichtner (7611605), A. Onipinla (7602377), Mark J Caulfield, Klopp, N, Caulfield, M.J., N. Samani (7611611), P. Juhanson (7602641), Dominiczak, Anna, Veldre, G., Connell, J., Connell, John, Norman Klopp, MRC British Genetics of Hypertension Study, Brown, M., Sõber, S., Howard, Philip, Brown Morris, Laan, M, Sõber, S;Org, E;Kepp, K;Juhanson, P;Eyheramendy, S;Gieger, C;Lichtner, P;Klopp, N;Veldre, G;Viigimaa, M;Döring, A;Putku, M;Kelgo, P;Shaw-Hawkins, S;Howard, P;Onipinla, A;Dobson, RJ;Newhouse, SJ;Brown, M;Dominiczak, A;Connell, J;Samani, N;Farrall, M;Caulfield, MJ;Munroe, PB;Illig, T;Wichmann, HE;Meitinger, T;Laan, M   +183 more
core   +1 more source

Genome-Wide Transcriptome Analysis in Type 2 Diabetes Patients Treated by Sitagliptin

Diabetes, Metabolic Syndrome and Obesity, 2022
Rui Ma,1 Xiao-long Deng,2 Qi-qi-ge Aleteng,1 Lei Li,1 Jun Zhu3 1Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, People’s Republic of China; 2Department of Endocrinology, Shunde Hospital
Ma R, Deng X, Aleteng Q, Li L, Zhu J
doaj  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source