Results 21 to 30 of about 25,155,128 (260)

Genome-wide association study of receptive language ability of 12 year olds [PDF]

open access: yes, 2013
Purpose: We have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. The current study attempted to identify some of the genes responsible for the heritability of receptive language ...
Hanscombe, K.B.   +32 more
core   +1 more source

Simultaneous Analysis of All SNPs in Genome-Wide and Re-Sequencing Association Studies [PDF]

open access: yes, 2008
Testing one SNP at a time does not fully realise the potential of genome-wide association studies to identify multiple causal variants, which is a plausible scenario for many complex diseases.
Maria De Iorio   +18 more
core   +1 more source

A genome-wide association search for type 2 diabetes genes in African Americans. [PDF]

open access: yes, 2012
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.
Kumari, Meena   +389 more
core   +3 more sources

Genome-wide analysis reveals coating of the mitochondrial genome by TFAM. [PDF]

open access: yesPLoS ONE, 2013
Mitochondria contain a 16.6 kb circular genome encoding 13 proteins as well as mitochondrial tRNAs and rRNAs. Copies of the genome are organized into nucleoids containing both DNA and proteins, including the machinery required for mtDNA replication and ...
Yun E Wang   +3 more
doaj   +1 more source

Improved heritability estimation from genome-wide SNPs [PDF]

open access: yes, 2012
Narrow-sense heritability (h(2)) is an important genetic parameter that quantifies the proportion of phenotypic variance in a trait attributable to the additive genetic variation generated by all causal variants.
Johnson, Michael R.   +7 more
core   +1 more source

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.

open access: yesPLoS Genetics, 2019
Pathological phosphorylated TDP-43 protein (pTDP) deposition drives neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP).
Nicole F Liachko   +6 more
doaj   +1 more source

Genome-Wide Association Studies of the PR Interval in African Americans [PDF]

open access: yes, 2011
The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races.
Paltoo, Dina N.   +181 more
core   +1 more source

Genome‑wide analysis of the MYB gene family in pumpkin [PDF]

open access: yesPeerJ
The MYB gene family exerts significant influence over various biological processes and stress responses in plants. Despite this, a comprehensive analysis of this gene family in pumpkin remains absent.
Minyan Xu   +3 more
doaj   +2 more sources

Genome wide identification of recessive cancer genes by combinatorial mutation analysis. [PDF]

open access: yesPLoS ONE, 2008
We devised a novel procedure to identify human cancer genes acting in a recessive manner. Our strategy was to combine the contributions of the different types of genetic alterations to loss of function: amino-acid substitutions, frame-shifts, gene ...
Stefano Volinia   +8 more
doaj   +1 more source

First genome-wide association study on anxiety-related behaviours in childhood [PDF]

open access: yes, 2013
Background: Twin studies have shown that anxiety in a general population sample of children involves both domain-general and trait-specific genetic effects.
Hanscombe, K.B.   +66 more
core   +1 more source

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