Results 21 to 30 of about 49,899 (262)
Genome-wide pathway analysis in glioma
Neoplasma, 2015 The aim of this study was to identify candidate single-nucleotide polymorphisms (SNPs) that may play a role in the susceptibility to glioma, to elucidate their potential mechanisms, and to generate SNP-to-gene-to-pathway hypotheses.A genome-wide association study (GWAS) dataset of glioma including 509,345 SNPs from 1,856 glioma patients and 4,955 ...
Y H, Lee, G G, Song
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Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.
PLoS Genetics, 2019 Pathological phosphorylated TDP-43 protein (pTDP) deposition drives neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP).
Nicole F Liachko +6 more
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Genome wide molecular analysis of minimally differentiated acute myeloid leukemia
Haematologica, 2009 Background Minimally differentiated acute myeloid leukemia is heterogeneous in karyotype and is defined by immature morphological and molecular characteristics.
Fernando P.G. Silva +12 more
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Genome wide identification of recessive cancer genes by combinatorial mutation analysis. [PDF]
PLoS ONE, 2008 We devised a novel procedure to identify human cancer genes acting in a recessive manner. Our strategy was to combine the contributions of the different types of genetic alterations to loss of function: amino-acid substitutions, frame-shifts, gene ...
Stefano Volinia +8 more
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Meta-Analysis in Genome-Wide Association Studies [PDF]
Pharmacogenomics, 2009 The advent of genome-wide association studies has allowed considerable progress in the identification and robust replication of common gene variants that confer susceptibility to common diseases and other phenotypes of interest. These genetic effect sizes are almost invariably moderate to small in magnitude and single studies, even if large, are ...
Zeggini, E., Ioannidis, J. P.
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Genome-Wide Gene-Based Multi-Trait Analysis
Frontiers in Genetics, 2020 Genome-wide association studies focusing on a single phenotype have been broadly conducted to identify genetic variants associated with a complex disease.
Yamin Deng +5 more
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Genome‐wide analysis of the AP2/ERF gene family inSalix arbutifolia
FEBS Open Bio, 2015 AP2/ERF genes encode transcriptional regulators with a variety of functions in plant growth and development and in response to biotic and abiotic stresses.
Guodong Rao +4 more
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Genome-wide pathway analysis in neuroblastoma
Tumor Biology, 2013 The aim of this study was to identify candidate single-nucleotide polymorphisms (SNPs) that might play a role in susceptibility to neuroblastoma, elucidate their potential mechanisms, and generate SNP-to-gene-to-pathway hypotheses. A genome-wide association study (GWAS) dataset of neuroblastoma that included 442,976 SNPs from 1,627 neuroblastoma ...
Young Ho, Lee +2 more
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Approximate conditional phenotype analysis based on genome wide association summary statistics
Scientific Reports, 2021 Because single genetic variants may have pleiotropic effects, one trait can be a confounder in a genome-wide association study (GWAS) that aims to identify loci associated with another trait.
Peitao Wu +5 more
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Comprehensive Analysis of SiNPs on the Genome-Wide Transcriptional Changes in Caenorhabditis elegans
International Journal of Nanomedicine, 2020 Shuang Liang,1,2,* Junchao Duan,1,2,* Hejing Hu,1,2 Jingyi Zhang,1,2 Shan Gao,2,3 Haiming Jing,2,3 Guojun Li,2,3 Zhiwei Sun1,2 1Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, People ...
Liang S +7 more
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