Results 1 to 10 of about 754,015 (260)
Genome wide analysis of
BMC Genomics, 2005 Background Core promoters are the gene regulatory regions most proximal to the transcription start site (TSS), central to the formation of pre-initiation complexes and for combinatorial gene regulation.
Molina Carlos, Grotewold Erich
doaj +3 more sources
Advances in genome-wide DNA methylation analysis [PDF]
BioTechniques, 2010 The covalent DNA modification of cytosine at position 5 (5-methylcytosine; 5mC) has emerged as an important epigenetic mark most commonly present in the context of CpG dinucleotides in mammalian cells.
Romi Gupta +2 more
doaj +3 more sources
Improved statistics for genome-wide interaction analysis. [PDF]
PLoS Genetics, 2012 Recently, Wu and colleagues [1] proposed two novel statistics for genome-wide interaction analysis using case/control or case-only data. In computer simulations, their proposed case/control statistic outperformed competing approaches, including the fast ...
Masao Ueki, Heather J Cordell
doaj +5 more sources
Genome-Wide Detection and Analysis of Multifunctional Genes. [PDF]
PLoS Computational Biology, 2015 Many genes can play a role in multiple biological processes or molecular functions. Identifying multifunctional genes at the genome-wide level and studying their properties can shed light upon the complexity of molecular events that underpin cellular ...
Yuri Pritykin, Dario Ghersi, Mona Singh
doaj +4 more sources
The value of genome-wide analysis in craniosynostosis
Frontiers in GeneticsBackground: This study assessed the diagnostic yield of high-throughput sequencing methods in a cohort of craniosynostosis (CS) patients not presenting causal variants identified through previous targeted analysis.Methods: Whole-genome or whole-exome ...
Alexandra Topa +12 more
doaj +3 more sources
Genome-wide analysis of miRNAs in Carya cathayensis [PDF]
BMC Plant Biology, 2017 Background MicroRNA (miRNA) plays an important role in plant development regulation. Hickory is an economically important plant in which the amount of flowering determines its production. Results Here, 51 conserved miRNAs, which belong to 16 families and
Zhi-chao Sun +2 more
doaj +3 more sources
Genome-wide analysis of insomnia disorder [PDF]
Molecular Psychiatry, 2018 Insomnia is a worldwide problem with substantial deleterious health effects. Twin studies have shown a heritable basis for various sleep-related traits, including insomnia, but robust genetic risk variants have just recently begun to be identified. We conducted genome-wide association studies (GWAS) of soldiers in the Army Study To Assess Risk and ...
Murray B. Stein +13 more
openaire +6 more sources
Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies. [PDF]
PLoS ONE, 2015 Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants.
Yongkang Kim, Taesung Park
doaj +1 more source
Genome-wide analysis of Alu editability [PDF]
Nucleic Acids Research, 2014 A-to-I RNA editing is apparently the most abundant post-transcriptional modification in primates. Virtually all editing sites reside within the repetitive Alu SINEs. Alu sequences are the dominant repeats in the human genome and thus are likely to pair with neighboring reversely oriented repeats and form double-stranded RNA structures that are bound by
L. Bazak, E. Y. Levanon, E. Eisenberg
openaire +2 more sources