Results 81 to 90 of about 827,205 (291)

Gene and Pathway-Based Analysis: Second Wave of Genome-wide Association Studies [PDF]

, 2008
Despite great success of GWAS in identification of common genetic variants associated with complex diseases, the current GWAS have focused on single SNP analysis.
Christopher I. Amos, Gang Peng, H1oicheong Siu, Jinying Zhao, John D. Reveille, Li Jin, Li Luo, Momiao Xiong, Pengfei Hu, Shengjun Hong, Xiaodong Zhou, Yun Zhu   +11 more
core   +1 more source

Genome-wide analysis of mRNAs associated with mouse peroxisomes [PDF]

BMC Genomics, 2016
RNA is often targeted to be localized to the specific subcellular compartments. Specific localization of mRNA is believed to be an important mechanism for targeting their protein products to the locations, where their function is required.In this study we performed the genome wide transcriptome analysis of peroxisome preparations from the mouse liver ...
Yarmishyn, Aliaksandr A., Kremenskoy, Maksym, Batagov, Arsen O., Preuss, Axel, Wong, Jin Huei, Kurochkin, Igor V.   +5 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The challenge of detecting genotype-by-methylation interaction: GAW20

BMC Genetics, 2018
Background GAW20 working group 5 brought together researchers who contributed 7 papers with the aim of evaluating methods to detect genetic by epigenetic interactions. GAW20 distributed real data from the Genetics of Lipid Lowering Drugs and Diet Network
Mariza de Andrade, E. Warwick Daw, Aldi T. Kraja, Virginia Fisher, Lan Wang, Ke Hu, Jing Li, Razvan Romanescu, Jenna Veenstra, Rui Sun, Haoyi Weng, Wenda Zhou   +11 more
doaj   +1 more source

Meta-analysis of genome-wide association studies of anxiety disorders. [PDF]

, 2016
Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common, etiologically complex conditions with a partially genetic basis.
Adkins, D., Aggen, S.H., Bigdeli, T., Boomsma, D., Byrne, E.M., Castelao, E., der Auwera, S.V., Direk, N., Fanous, A., Gordon, S., Grabe, H.J., Hartman, C.A., Heath, A.C., Hek, K., Henders, A.K., Hettema, J.M., Hofman, A., Homuth, G., Hottenga, J.J., Keller, M.C., Kutalik, Z., Lee, M., Madden, P.A., Maher, B.S., Martin, N.G., Medland, S.E., Middeldorp, C.M., Milaneschi, Y., Mirza, S.S., Montgomery, G., Mulder, C.L., Nauck, M., Nivard, M.G., Nolte, I.M., Oldehinkel, A.J., Otowa, T., Penninx, B.W., Pergadia, M.L., Preisig, M., Teumer, A., Tiemeier, H., Uitterlinden, A., van den Oord, E.J., van der Most, P.J., van Oort, F.V., Wolen, A., Wray, N.R.   +46 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Genome‐Wide Association Analysis Identifies LILRB2 Gene for Pathological Myopia

Advanced Science
Pathological myopia (PM) is one of the leading causes of blindness, especially in Asia. To identify the genetic risk factors of PM, a two‐stage genome‐wide association study (GWAS) and replication analysis in East Asian populations is conducted.
Lingxi Jiang, Lulin Huang, Chao Dai, Rui Zheng, Masahiro Miyake, Yuki Mori, Shin‐ya Nakao, Kazuya Morino, Kenji Ymashiro, Yang‐Bao Miao, Qi Li, Weiming Ren, Zimeng Ye, Hongjing Li, Zhenglin Yang, Yi Shi   +15 more
doaj   +1 more source

Genome-Wide Association and Linkage Analysis of Quantitative Traits: Comparison pf Likelihood-Ratio Test and Conditional Score Statistic [PDF]

, 2009
Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype.
Dupuis, Josée, Hendricks, Audrey E, Zhu, Yanyan   +2 more
core   +1 more source

Patterns of genetic diversity and linkage disequilibrium in a highly structured Hordeum vulgare association-mapping population for the Mediterranean basin [PDF]

, 2009
Population structure and genome-wide linkage disequilibrium (LD) were investigated in 192 Hordeum vulgare accessions providing a comprehensive coverage of past and present barley breeding in the Mediterranean basin, using 50 nuclear microsatellite and 1 ...
Akar, T., Al-Yassin, A., Benbelkacem, A., Bort, J., Ceccarelli, S., Comodran, J., Eeuwijk, F.A., van, Grando, S., Hackett, C.A., Ouabbou, H., Pecchioni, N., Romagosa, I., Russel, J.R., Stanca, A.M., Thomas, W.T.B.   +14 more
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source