Results 61 to 70 of about 827,205 (291)

A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. [PDF]

, 2016
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone ...
Bian, Zhaolian, Chen, Haoyan, Gershwin, M Eric, Jiang, Xiang, Li, Enling, Li, Zhiqiang, Lian, Min, Liao, Wilson, Ma, Xiong, Miao, Qi, Seldin, Michael F, Shi, Yongyong, Tang, Ruqi, Wang, Qixia, Wang, Zhaoyue, Wei, Yiran, Yang, Fan, Yang, Yue, Zhang, Haiyan   +18 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Identification of Drought-Tolerance Genes in the Germination Stage of Soybean

Biology, 2022
Drought stress influences the vigor of plant seeds and inhibits seed germination, making it one of the primary environmental factors adversely affecting food security.
Xingzhen Zhao, Zhangxiong Liu, Huihui Li, Yanjun Zhang, Lili Yu, Xusheng Qi, Huawei Gao, Yinghui Li, Lijuan Qiu   +8 more
doaj   +1 more source

Genome-wide association study identifies 30 loci associated with bipolar disorder. [PDF]

, 2019
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional
Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D, Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A, Barchas, Jack D, Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E, Boks, Marco P, Boocock, James, Breen, Gerome, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Byrne, Enda M, Bækvad-Hansen, Marie, Bøen, Erlend, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W, Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coleman, Jonathan RI, Coryell, William, Craig, David W, Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M, Dale, Anders M, de Jong, Simone, de Leeuw, Christiaan A, Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J Raymond, Djurovic, Srdjan, Dobbyn, Amanda L, Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B, Flickinger, Matthew, Foroud, Tatiana M, Forstner, Andreas J, Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B, Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Gaspar, Héléna A, Giambartolomei, Claudia, Goldstein, Jaqueline, Gordon, Scott D, Gordon-Smith, Katherine, Green, Elaine K, Green, Melissa J, Greenwood, Tiffany A, Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L, Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Holmans, Peter A, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S, Juréus, Anders, Mattheisen, Manuel, McQuillin, Andrew, Pavlides, Jennifer M Whitehead, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Pers, Tune H, Richards, Alexander L, Ripke, Stephan, Stahl, Eli A, Steinberg, Stacy, Trubetskoy, Vassily, Trzaskowski, Maciej, Wang, Yunpeng   +99 more
core  

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. [PDF]

, 2017
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability.
Banda, Yambazi, Choquet, Hélène, Hoffmann, Thomas J, Jorgenson, Eric, Kvale, Mark N, Melles, Ronald, Nair, K Saidas, Risch, Neil, Schaefer, Catherine, Thai, Khanh K, Yin, Jie   +10 more
core   +3 more sources

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque [PDF]

, 2011
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events.
A Dehghan, Aaron Isaacs, Abbas Dehghan, AD Johnson, AD Johnson, Afshin Parsa, Alan R Shuldiner, Albert Hofman, Albert V Smith, AM Bennet, Andre Uitterlinden, Andreas Ziegler, Angelo Scuteri, Anne B Newman, Arne Schillert, Ben Oostra, BM Psaty, Bolli Thorsson, Braxton D Mitchell, Bruce M Psaty, C Meisinger, C Sabatti, Caroline Hayward, Caroline S Fox, Charles C White, Christa Meisinger, Christie Ballantyne, Christopher J O'Donnell, Cornelia van Duijn, CS Fox, D Lloyd-Jones, D Wang, Daniel H O'Leary, David J Couper, DI Chasman, DI Chasman, E Falk, EB Mathiesen, Edward G Lakatta, Eran Halperin, Eric Boerwinkle, Eva-Maria Stoegerer, Fernando Rivadeneira, Florian Ernst, Georg Homuth, Gerardo Heiss, Gianluca Usala, Gonçalo R Abecasis, Gudny Eiriksdottir, H Erich Wichmann, H Schunkert, H Yasuda, Helena Schmidt, Henry Völzke, Hugh S Markus, Jacqueline Witteman, James F Wilson, Jan Lüdemann, Jennifer E Huffman, Jens Baumert, Jerome I Rotter, JH Stein, Joachim Thiery, Jochen Seissler, Jorma Viikari, Joseph F Polak, Joshua C Bis, K Stark, K Yuan, Kari North, Katja E Petrovic, Kenneth Rice, Kent Taylor, L Adrienne Cupples, L Paternoster, Leena Peltonen, Lenore J Launer, M Kolz, M Oguri, Manuela Uda, Marco Orru, Marcus Dörr, Maryam Kavousi, Matthias Sitzer, Mika Kähönen, Muredach P Reilly, MW Lorenz, N Soranzo, Nora Franceschini, Norman Klopp, Olli Raitakari, P Greenland, Philip A Wolf, Philipp S Wild, R Nakov, R Ross, Ralph B D'Agostino, Ravi Kumar Chilukoti, Reinhold Schmidt, Renate B Schnabel, S Kathiresan, S Kathiresan, Sekar Kathiresan, Serena Sanna, Serkalem Demissie, SH Johnsen, Stefan Blankenberg, Steve Bevan, Susan R Heckbert, T Rahman, TA Manolio, Tamara B Harris, Tanja Zeller, Terho Lehtimäki, Thomas Illig, Thomas Münzel, Thor Aspelund, Ulf Schminke, V Nambi, Vijay Nambi, Vilmundur Gudnason, W Insull Jr., Wendy S Post, Wolfgang Koenig, Wolfgang Rathmann, Xia Li, XZ Zhou, YS Aulchenko, Yu-Ching Cheng   +128 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Genome wide in silico SNP-tumor association analysis

BMC Cancer, 2004
Background Carcinogenesis occurs, at least in part, due to the accumulation of mutations in critical genes that control the mechanisms of cell proliferation, differentiation and death.
Simon Jason S, Ding Wei, Kostich Mitch, Wang Luquan, Qiu Ping, Greene Jonathan R   +5 more
doaj  

Identification of loci associated with conception rate in primiparous Holstein cows

BMC Genomics, 2019
Background Subfertility is a major issue facing the dairy industry as the average US Holstein cow conception rate (CCR) is approximately 35%. The genetics underlying the physiological processes responsible for CCR, the proportion of cows able to conceive
Jennifer N. Kiser, Erin Clancey, Joao G. N. Moraes, Joseph Dalton, Gregory W. Burns, Thomas E. Spencer, Holly L. Neibergs   +6 more
doaj   +1 more source

Genome-Wide Investigation of the Phospholipase C Gene Family in Zea mays

Frontiers in Genetics, 2021
Phospholipase C (PLC) is one of the main hydrolytic enzymes in the metabolism of phosphoinositide and plays an important role in a variety of signal transduction processes responding to plant growth, development, and stress.
Jiantang Zhu, Yuanyuan Zhou, Jiale Li, Hui Li   +3 more
doaj   +1 more source