Results 51 to 60 of about 827,205 (291)

Meta‐analysis of sex‐specific genome‐wide association studies [PDF]

Genetic Epidemiology, 2010
AbstractDespite the success of genome‐wide association studies, much of the genetic contribution to complex human traits is still unexplained. One potential source of genetic variation that may contribute to this “missing heritability” is that which differs in magnitude and/or direction between males and females, which could result from sexual ...
Magi, R, Lindgren, C, Morris, A
openaire   +2 more sources

Genome wide association analysis in a mouse advanced intercross line

Nature Communications, 2018
Multigenerational outbred populations from an advanced intercross line (AIL) of mice represent useful resources for genome wide association analysis.
Natalia M. Gonzales, Jungkyun Seo, Ana I. Hernandez Cordero, Celine L. St. Pierre, Jennifer S. Gregory, Margaret G. Distler, Mark Abney, Stefan Canzar, Arimantas Lionikas, Abraham A. Palmer   +9 more
doaj   +1 more source

Rice Galaxy: An open resource for plant science [PDF]

, 2019
Background: Rice molecular genetics, breeding, genetic diversity, and allied research (such as rice-pathogen interaction) have adopted sequencing technologies and high-density genotyping platforms for genome variation analysis and gene discovery ...
Alexandrov, Nickolai, Beaume, Nicolas, Dereeper, Alexis, Dizon, Joshua, Droc, Gaëtan, Haga, Jason, Juanillas, Venice, Kretzschmar, Tobias, Lang, Jillian M., Larmande, Pierre, Leach, Jan E., Mansueto, Locedie, Mauleon, Ramil P., Mendoza, John Robert, Perdon, Jon Peter, Plale, Beth, Ratharanjan, Kunalan, Ruiz, Manuel, Thomson, Michael J., Triplett, Lindsay, Zhou, Gabriel   +20 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Genome‐wide association analysis of hyperspectral reflectance data to dissect the genetic architecture of growth‐related traits in maize under plant growth‐promoting bacteria inoculation

Plant Direct, 2023
Plant growth‐promoting bacteria (PGPB) may be of use for increasing crop yield and plant resilience to biotic and abiotic stressors. Using hyperspectral reflectance data to assess growth‐related traits may shed light on the underlying genetics as such ...
Rafael Massahiro Yassue, Giovanni Galli, Chun‐Peng James Chen, Roberto Fritsche‐Neto, Gota Morota   +4 more
doaj   +1 more source

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. [PDF]

, 2011
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including ...
Abel, Rebekah A, Adkinson, N Franklin, Ampleford, Elizabeth J, Avila, Lydiana, Avila, Pedro C, Barnes, Kathleen C, Baurley, James W, Beaty, Terri H, Bleecker, Eugene R, Burchard, Esteban G, Busse, William W, Calhoun, William J, Capurso, Daniel, Castro, Mario, Celedón, Juan C, Chapela, Rocio, Childhood Asthma Management Program (CAMP), Childhood Asthma Research and Education (CARE) Network, Children's Health Study (CHS) and HARBORS study, Chiu, Grace Y, Chung, Kian Fan, Conti, David V, Deichmann, Klaus A, del Rio-Navarro, Blanca, Diette, Gregory B, Dunston, Georgia M, Eng, Celeste, Ezurum, Serpil C, Faruque, Mezbah U, Ford, Jean G, Galanter, Joshua, Gauderman, W James, Genetic Research on Asthma in African Diaspora (GRAAD) Study, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE), Gern, James E, Gignoux, Christopher R, Gilliland, Frank D, Graves, Penelope E, Hancock, Dana B, Hansel, Nadia N, Heinzmann, Andrea, Hernandez, Ryan D, Himes, Blanca E, Hu, Donglei, Huntsman, Scott, Israel, Elliott, Lemanske, Robert F, Levin, Albert M, Li, Xia, Li, Xingnan, Liang, Liming, London, Stephanie J, Mantese, Vito J, Martinez, Fernando D, Mathias, Rasika A, Mexico City Childhood Asthma Study (MCAAS), Meyers, Deborah A, Myers, Rachel A, Nicolae, Dan L, Ober, Carole, Raby, Benjamin A, Rafaels, Nicholas, Rodriguez-Cintron, William, Rodriquez-Santana, Jose R, Romieu, Isabelle, Ross, Kevin D, Roth, Lindsey A, Ruczinski, Ingo, Salam, Muhammad T, Shi, Min, Sienra-Monge, Juan J, Soto-Quiros, Manuel, Stern, Debra A, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Togias, Alkis, Torgerson, Dara G, Van Den Berg, David J, Vora, Hita, Watson, Harold R, Weiss, Scott T, Wenzel, Sally E, Williams, L Keoki   +81 more
core   +2 more sources

Phenotype-specific association of the TGFBR3 locus with nonsyndromic cryptorchidism [PDF]

, 2015
PURPOSE: Based on a genome-wide association study of testicular dysgenesis syndrome showing a possible association with TGFBR3, we analyzed data from a larger, phenotypically restricted cryptorchidism population for potential replication of this signal.
Abrams, D, Akins, R, Banihani, A, Barthold, J, Chiavacci, R, Devoto, Marcella, Figueroa, E, Gonzalez, R, Hagerty, J, Hakonarson, H, Harden, K, Kolon, T, Li, J, Mateson, A, Noh, P, Nordenskjöld, A, Olivant Fisher, A, Robbins, A, Wang, Y   +18 more
core   +1 more source

Pigment Intensity in Dogs is Associated with a Copy Number Variant Upstream of KITLG. [PDF]

, 2020
Dogs exhibit a wide variety of coat color types, and many genes have been identified that control pigment production, appearance, and distribution. Some breeds, such as the Nova Scotia Duck Tolling Retriever (NSDTR), exhibit variation in pheomelanin ...
Affolter, Verena, Bannasch, Danika, Grahn, Robert, Kallenberg, Angelica, Rebhun, Robert, Weich, Kalie, York, Daniel   +6 more
core   +2 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source