Results 41 to 50 of about 827,205 (291)

Integrated Genome-Wide Pathway Association Analysis with INTERSNP [PDF]

Human Heredity, 2012
<i>Objectives:</i> Pathway association analysis (PAA) tests for an excess of moderately significant SNPs in genes from a common pathway. <i>Methods:</i> We present a Monte-Carlo simulation framework that allows to formulate the main ideas of existing PAA approaches using a self-contained rather than a competitive null hypothesis.
Herold, Christine, Mattheisen, Manuel, Lacour, André, Vaitsiakhovich, Tatsiana, Angisch, Marina, Drichel, Dmitriy, Becker, Tim   +6 more
openaire   +3 more sources

Pathway analysis comparison using Crohn's disease genome wide association studies

BMC Medical Genomics, 2010
Background The use of biological annotation such as genes and pathways in the analysis of gene expression data has aided the identification of genes for follow-up studies and suggested functional information to uncharacterized genes. Several studies have
Cho Judy, Abraham Clara, Ballard David, Zhao Hongyu   +3 more
doaj   +1 more source

A quantitative trait locus on chromosome 2 was identified that accounts for a substantial proportion of phenotypic variance of the yellow plumage color in chicken

Poultry Science, 2020
Chicken plumage color is an important economical trait in poultry breeding, as triple-yellow indigenous broilers are preferred over western commercial broilers in the Chinese market.
Tao Huang, Yuejin Pu, Chi Song, Zheya Sheng, Xiaoxiang Hu   +4 more
doaj   +1 more source

Fine mapping by composite genome-wide association analysis [PDF]

Genetics Research, 2017
SummaryGenome-wide association (GWA) studies play a key role in current genetics research, unravelling genomic regions linked to phenotypic traits of interest in multiple species. Nevertheless, the extent of linkage disequilibrium (LD) may provide confounding results when significant genetic markers span along several contiguous cM.
CASELLAS, JOAQUIM, CAÑAS-ÁLVAREZ, JHON JACOBO, FINA, MARTA, PIEDRAFITA, JESÚS, CECCHINATO, ALESSIO   +4 more
openaire   +3 more sources

Association Signals Unveiled by a Comprehensive Gene Set Enrichment Analysis of Dental Caries Genome-Wide Association Studies [PDF]

, 2013
Gene set-based analysis of genome-wide association study (GWAS) data has recently emerged as a useful approach to examine the joint effects of multiple risk loci in complex human diseases or phenotypes.
Cuenco, Karen T., Feingold, Eleanor, Jia, Peilin, Marazita, Mary L., Wang, Kai, Wang, Lily, Wang, Quan, Zeng, Zhen, Zhao, Zhongming   +8 more
core   +3 more sources

Weighted SNP set analysis in genome-wide association study. [PDF]

PLoS ONE, 2013
Genome-wide association studies (GWAS) are popular for identifying genetic variants which are associated with disease risk. Many approaches have been proposed to test multiple single nucleotide polymorphisms (SNPs) in a region simultaneously which ...
Hui Dai, Yang Zhao, Cheng Qian, Min Cai, Ruyang Zhang, Minjie Chu, Juncheng Dai, Zhibin Hu, Hongbing Shen, Feng Chen   +9 more
doaj   +1 more source

Genetic associations with childhood brain growth, defined in two longitudinal cohorts [PDF]

, 2018
Genome-wide association studies (GWASs) are unraveling the genetics of adult brain neuroanatomy as measured by cross-sectional anatomic magnetic resonance imaging (aMRI). However, the genetic mechanisms that shape childhood brain development are, as yet,
Jansen, Philip R., Justice, Cristina M., Muetzel, Ryan L., Sabourin, Jeremy A., Schwantes-An, Tae-Hwi Linus, Sharp, Wendy, Shaw, Philip, Sung, Heejong, Szekely, Eszter, Tiemeier, Henning, White, Tonya J., Wilson, Alexander F.   +11 more
core   +1 more source

Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances [PDF]

, 2013
Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption we performed a population based genome-wide association study ...
Alexei I. Zhurov, Anja Taanila, Anneli Pouta, Arshed M. Toma, Bakrania, Bayés de Luna, Beate St Pourcain, Bei, Bjarke Feenstra, Clive J. Hoggart, Cole, Cornelis, David M. Evans, Demetris Pillas, Di Cello, Eleftherohorinou, Eleftherohorinou, Elks, Ellen A. Nohr, Frank Geller, Freedman, Fujiwara, Geller, George Davey Smith, Ghazaleh Fatemifar, Golding, Goyal, Gu, Gudbjartsson, Hammarsund, Haraguchi, Hikake, Holmans, Horikoshi, Houlston, Hughes, Inga Prokopenko, Jernvall, Jia, John P. Kemp, Jon H. Tobias, Jussila, Kang, Kere, Kirsi Sipila, Lango Allen, Lavinia Paternoster, Levy, Li, Ligon, Mads Melbye, Marjo-Riitta Jarvelin, Meindl, Mikkola, Momoko Horikoshi, Mustonen, Nicholas J. Timpson, Nohr, Nunes, Nyholt, Paternoster, Pillas, Pispa, Pruim, Raija Lähdesmäki, Sabatti, Sakuraba, Simón-Sánchez, Soranzo, Srivastava, Stein, Stephen Richmond, Susan M. Ring, Taal, Taviaux, Tummers, Vainio, Vaz, Victoria J. Wright, Weedon, Willer, Wise, Yabe, Yang, Zhang   +84 more
core   +2 more sources

Genome-wide efficient mixed-model analysis for association studies [PDF]

Nature Genetics, 2012
Linear mixed models have attracted considerable attention recently as a powerful and effective tool for accounting for population stratification and relatedness in genetic association tests. However, existing methods for exact computation of standard test statistics are computationally impractical for even moderate-sized genome-wide association studies.
Zhou, Xiang, Stephens, Matthew
openaire   +2 more sources

A foundation for provitamin A biofortification of maize: genome-wide association and genomic prediction models of carotenoid levels. [PDF]

, 2014
Efforts are underway for development of crops with improved levels of provitamin A carotenoids to help combat dietary vitamin A deficiency. As a global staple crop with considerable variation in kernel carotenoid composition, maize (Zea mays L.) could ...
Buckler, Edward S, Buell, C Robin, Cepela, Jason, DellaPenna, Dean, Diepenbrock, Christine H, Gore, Michael A, Kandianis, Catherine B, Kim, Eunha, Lipka, Alexander E, Magallanes-Lundback, Maria, Mateos-Hernandez, Maria, Owens, Brenda F, Rocheford, Torbert, Tiede, Tyler   +13 more
core   +1 more source