Results 31 to 40 of about 827,205 (291)

Genome-wide polygenic analysis of multiple sclerosis markers

Неврология, нейропсихиатрия, психосоматика, 2021
Objective: to perform a genome-wide polygenic analysis of multiple sclerosis (MS) markers in the ethnic groups of Bashkirs, Russians, and Tatars living in the Republic of Bashkortostan (Russian Federation).Patients and methods.
Ya. R. Timasheva, T. R. Nasibullin, I. A. Tuktarova, V. V. Erdman, T. R. Galiullin, O. V. Zaplakhova, K. Z. Bakhtiiarova   +6 more
doaj   +1 more source

SNP2GO: Functional Analysis of Genome-Wide Association Studies [PDF]

Genetics, 2014
AbstractGenome-wide association studies (GWAS) are designed to identify the portion of single-nucleotide polymorphisms (SNPs) in genome sequences associated with a complex trait. Strategies based on the gene list enrichment concept are currently applied for the functional analysis of GWAS, according to which a significant overrepresentation of ...
David, Szkiba, Martin, Kapun, Arndt, von Haeseler, Miguel, Gallach   +3 more
openaire   +2 more sources

Statistical analysis for genome-wide association study

The Journal of Biomedical Research, 2015
In the past few years, genome-wide association study (GWAS) has made great successes in identifying genetic susceptibility loci underlying many complex diseases and traits. The findings provide important genetic insights into understanding pathogenesis of diseases.
Zeng, Ping, Zhao, Yang, Qian, Cheng, Zhang, Liwei, Zhang, Ruyang, Gou, Jianwei, Liu, Jin, Liu, Liya, Chen, Feng   +8 more
openaire   +2 more sources

Genome-Wide Association Study and Pathway-Level Analysis of Kernel Color in Maize. [PDF]

, 2019
Rapid development and adoption of biofortified, provitamin A-dense orange maize (Zea mays L.) varieties could be facilitated by a greater understanding of the natural variation underlying kernel color, including as it relates to carotenoid biosynthesis ...
Diepenbrock, Christine H, Gore, Michael A, Mateos-Hernandez, Maria, Mathew, Deepu, Owens, Brenda F, Rocheford, Torbert, Tiede, Tyler, Wu, Di   +7 more
core   +2 more sources

Secure genome-wide association analysis using multiparty computation [PDF]

Nature Biotechnology, 2018
Most sequenced genomes are currently stored in strict access-controlled repositories. Free access to these data could improve the power of genome-wide association studies (GWAS) to identify disease-causing genetic variants and aid the discovery of new drug targets.
Hyunghoon Cho, David J Wu, Bonnie Berger
openaire   +2 more sources

A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia

Clinical and Translational Medicine, 2020
Backgrounds To explore the genetic correlation between schizophrenia (SCZ) and osteoporosis (OP). Design, setting, participants, measurements We conducted a trans-ethnic two-stage genetic correlation analysis of OP and SCZ, totally invoking 2286 Caucasia
Li Liu, Yan Wen, Yujie Ning, Ping Li, Bolun Cheng, Shiqiang Cheng, Lu Zhang, Mei Ma, Xin Qi, Chujun Liang, Tielin Yang, Xiangding Chen, Lijun Tan, Hui Shen, Qing Tian, Hong-Wen Deng, Xiancang Ma, Feng Zhang, Feng Zhu   +18 more
doaj   +1 more source

Genome-wide association interaction analysis for Alzheimer's disease

Neurobiology of Aging, 2014
We propose a minimal protocol for exhaustive genome-wide association interaction analysis that involves screening for epistasis over large-scale genomic data combining strengths of different methods and statistical tools. The different steps of this protocol are illustrated on a real-life data application for Alzheimer's disease (AD) (2259 patients and
Gusareva, Elena S., Carrasquillo, Minerva M., Bellenguez, Céline, Cuyvers, Elise, Colon, Samuel, Graff-Radford, Neill R., Petersen, Ronald C., Dickson, Dennis W., Mahachie John, Jestinah M., Bessonov, Kyrylo, Van Broeckhoven, Christine, Harold, Denise, Williams, Julie, Amouyel, Philippe, Sleegers, Kristel, Ertekin-Taner, Nilüfer, Lambert, Jean-Charles, Van Steen, Kristel   +17 more
openaire   +3 more sources

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms [PDF]

, 2015
Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,
Aranaz, P., Aranaz, P., Bandinelli, S., Bandinelli, S., Barosi, G., Barosi, G., Baxter, E.J., Baxter, E.J., Callaway, A., Callaway, A., Campbell P., Campbell P., Cazzola, M., Cazzola, M., Chase, A., Chase, A., Chen, E., Chen, E., Cross N.C., Cross N.C., Dohner, K., Dohner, K., Duncombe, A.S., Duncombe, A.S., Evans, P., Evans, P., Ewing, J., Ewing, J., Gale, R.E., Gale, R.E., Giannopoulos, A., Giannopoulos, A., Gisslinger, H., Gisslinger, H., Godfrey, A.L., Godfrey, A.L., Grallert, H., Grallert, H., Green, A.R., Green, A.R., Griffiths, M., Griffiths, M., Guglielmelli, P., Guglielmelli, P., Haferlach, T., Haferlach, T., Harrison, C., Harrison, C., Harutyunyan, A.S., Harutyunyan, A.S., Jack, A., Jack, A., Jones, A.V., Jones, A.V., Kralovics, R., Kralovics, R., Leung, W., Leung, W., Lin, F., Lin, F., Maclean, C., Maclean, C., Mannarelli, C., Mannarelli, C., Mead, A.J., Mead, A.J., Nangalia, J., Nangalia, J., Oscier, D., Oscier, D., Pieri, L., Pieri, L., Reiter, A., Reiter, A., Schnittger, S., Schnittger, S., Schuh, A., Schuh, A., Short, M., Short, M., Stegelmann, F., Stegelmann, F., Strauch, K., Strauch, K., Tanaka, T., Tanaka, T., Tapper, W., Tapper, W., Vannucchi, A., Vannucchi, A., Waghorn, K., Waghorn, K., Wallis, L., Wallis, L., Ward, D., Ward, D., White, H.E., White, H.E., Zoi, K., Zoi, K.   +99 more
core   +5 more sources

Approximate conditional phenotype analysis based on genome wide association summary statistics

Scientific Reports, 2021
Because single genetic variants may have pleiotropic effects, one trait can be a confounder in a genome-wide association study (GWAS) that aims to identify loci associated with another trait.
Peitao Wu, Biqi Wang, Steven A. Lubitz, Emelia J. Benjamin, James B. Meigs, Josée Dupuis   +5 more
doaj   +1 more source

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. [PDF]

, 2019
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Bagchi, Aranya, Barnes, Hanna J, Bloch, Donald B, Bowden, Donald W, Budoff, Matthew, Buswell, Mary D, Buys, Emmanuel S, Campbell, Catherine Y, Criqui, Michael H, Debette, Stephanie, Erbel, Raimund, Feitosa, Mary F, Franceschini, Nora, Freedman, Barry I, Gudnason, Vilmundur, Guo, Xiuqing, Harris, Tamara, Hoffmann, Udo, Hwang, Shih-Jen, Johnson, Andrew D, Jöckel, Karl-Heinz, Kälsch, Hagen, Lindsay, Mark E, Lino Cardenas, Christian L, Lu, Lingyi, Malhotra, Rajeev, Mauer, Andreas C, Moebus, Susanne, Nicholson, Christopher J, Nigwekar, Sagar U, Nöthen, Markus M, O'Donnell, Christopher J, Pechlivanis, Sonali, Post, Wendy S, Rhee, David K, Rotter, Jerome I, Rourke, Caitlin O', Shelton, Georgia, Sigurdsson, Sigurdur, Sigurslid, Haakon H, Slocum, Charles, Smith, Albert V, Song, Ci, Thanassoulis, George, Wang, Judy, Wong, Quenna, Wunderer, Florian, Yao, Jie, Zapol, Warren M, Zhang, Xiaoling   +49 more
core   +1 more source