Results 291 to 300 of about 189,144 (345)

Serum Levels and Genetic Variants of CC16: Associations With Asthma and Lung Function Development

Clinical &Experimental Allergy, EarlyView.
Hans Jacob L. Koefoed, Yidan Sun, Ilse Hugtenburg, Stefano Guerra, Ulrike Gehring, Roel Vermeulen, Judith M. Vonk, Gerard H. Koppelman   +7 more
wiley   +1 more source

Deep Learning Enables Genome-Wide Association Studies of Microvascular Features

Elwakil A, Strebel S, Charbonnier M, Quiros JV, Liefers B, Belatchane L, Foa N, Bergmann S, Klaver C, Bergin C, Schlingemann R, VascX Research Consortium, Tomasoni M, Meloni I.   +13 more
europepmc   +1 more source

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Genome-Wide Association Studies (GWAS)

2023
Most of the breeding targets are quantitative traits. In exploring the quantitative trait locus (QTL) system of a trait, linkage mapping was established using sparse polymerase chain reaction (PCR) markers. With the genome-wide sequencing technology advanced, genome-wide association study (GWAS) was developed for natural (germplasm) populations using ...
Jianbo, He, Junyi, Gai
openaire   +2 more sources

Genome-Wide Association Studies (GWAS)

2022
Genome-wide association studies (GWAS) are designed to find associations between genomic variants and a phenotype, usually a complex multifactorial disease. The idea for association studies in a large cohort was floated after linkage analysis, which proved extremely successful in the identification of causative genes for rare disorders, but it did not ...
Hafiza Noor Ul Ayan, Muhammad Tariq
openaire   +1 more source

Genome-Wide Association Studies (GWAS)

2012
Genome-wide association studies (GWAS) have revolutionized our understanding of common diseases at the molecular level. This chapter discusses these strategies and describes key recent successes in stroke.
Guillaume Pare, Matthew P. A. Henderson
openaire   +1 more source

Statistical Perspectives for Genome-Wide Association Studies (GWAS)

2014
In this chapter we consider some key elements in conducting a successful genome-wide association study or GWAS. The first step is to design the study well (Subheading 3.1), paying particular attention to case and control selection and achieving adequate sample size to deal with the large burden of multiple testing.
Jennifer H, Barrett, John C, Taylor, Mark M, Iles   +2 more
openaire   +2 more sources

Bioinformatics Challenges in Genome-Wide Association Studies (GWAS)

2014
Genome-wide association studies (GWAS) are a powerful tool for investigators to examine the human genome to detect genetic risk factors, reveal the genetic architecture of diseases and open up new opportunities for treatment and prevention. However, despite its successes, GWAS have not been able to identify genetic loci that are effective classifiers ...
Rishika, De, William S, Bush, Jason H, Moore   +2 more
openaire   +2 more sources

Genome-Wide Association Studies (GWAS) of Adiposity

2016
Adiposity is strongly heritable and one of the leading risk factors for type 2 diabetes, cardiovascular disease, cancer, and premature death. In the past 8 years, genome-wide association studies (GWAS) have greatly increased our understanding of the genes and biological pathways that regulate adiposity by identifying more than 100 novel susceptibility ...
Oskari Kilpeläinen, Tuomas, Ingelsson, Erik   +1 more
openaire   +2 more sources

Planning and Executing a Genome Wide Association Study (GWAS)

2009
In recent years, genome-wide association approaches have proven a powerful and successful strategy to identify genetic contributors to complex traits, including a number of endocrine disorders. Their success has meant that genome wide association studies (GWAS) are fast becoming the default study design for discovery of new genetic variants that ...
Michèle M, Sale, Josyf C, Mychaleckyj, Wei-Min, Chen   +2 more
openaire   +2 more sources

Genome-wide association study (GWAS) for molar–incisor hypomineralization (MIH)

Clinical Oral Investigations, 2013
This genome-wide association study (GWAS) investigated the relationship between molar-incisor hypomineralization (MIH) and possible genetic loci. Clinical and genetic data from the 10-year follow-up of 668 children from the Munich GINI-plus and LISA-plus birth cohort studies were analyzed.The dental examinations included the diagnosis of MIH according ...
Jan, Kühnisch, Elisabeth, Thiering, Daniela, Heitmüller, Carla M T, Tiesler, Harald, Grallert, Roswitha, Heinrich-Weltzien, Reinhard, Hickel, Joachim, Heinrich   +7 more
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