Results 161 to 170 of about 674,070 (352)

Insights into the Genetic Architecture of Early Stage Age-Related Macular Degeneration: A Genome-Wide Association Study Meta-Analysis

, 2013
Parker Magin, Albert V. Smith, Belinda K. Cornes, Gabriëlle H.S. Buitendijk, Richard A. Jensen, Xueling Sim, Thor Aspelund, Tin Aung, Paul N. Baird, Eric Boerwinkle, Ching‐Yu Cheng, Cornelia M. van Duijn, Guðný Eiríksdóttir, Vilmundur Guðnason, Tamara B. Harris, Alex W. Hewitt, Michael Inouye, Friðbert Jónasson, Barbara E.K. Klein, Lenore J. Launer, Xiaohui Li, Gerald Liew, Thomas Lumley, Patrick McElduff, Barbara McKnight, Paul Mitchell, Bruce M. Psaty, Elena Rochtchina, Jerome I. Rotter, Rodney J. Scott, Wan-Ting Tay, Kent D. Taylor, Yik Ying Teo, André G. Uitterlinden, Ananth C. Viswanathan, Sophia Xie, Johannes R. Vingerling, Caroline C. W. Klaver, E Shyong Tai, David S. Siscovick, Ronald Klein, Mary Frances Cotch, Tien Yin Wong, John Attia, Jie Jin Wang   +44 more
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Research following genome‐wide association study focuses on the multifaceted nature of Src kinase‐associated phosphoprotein 2 in type 1 diabetes [PDF]

, 2022
Hiroyuki Sano, Akihisa Imagawa
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Assessing the Causal Impact of Social Isolation on Angina Risk: Evidence from a Two-Sample Mendelian Randomization Study

Journal of Multidisciplinary Healthcare
Shenghua Yan,1,* Feifei Gu,2,* Bei Tian1,2 1Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai, 201203, People’s Republic of China; 2Department of Nursing, Shanghai Pudong New Area Zhoupu Hospital (Shanghai Health Medical ...
Yan S, Gu F, Tian B
doaj  

Genome-wide association study of carcass traits in an Angus beef cattle Russian herd using imputed Whole-Genome Sequence data

, 2022

openalex   +1 more source

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

Nature Genetics, 2009
J. Lambert, S. Heath, G. Even, D. Campion, K. Sleegers, M. Hiltunen, O. Combarros, D. Zélénika, M. Bullido, B. Tavernier, L. Letenneur, K. Bettens, C. Berr, F. Pasquier, N. Fievet, P. Barberger‐Gateau, S. Engelborghs, P. Deyn, I. Mateo, A. Franck, S. Helisalmi, E. Porcellini, O. Hanon, M. Pancorbo, C. Lendon, C. Dufouil, C. Jaillard, T. Léveillard, V. Álvarez, P. Bosco, M. Mancuso, F. Panza, B. Nacmias, P. Bossù, P. Piccardi, G. Annoni, D. Seripa, D. Galimberti, D. Hannequin, F. Licastro, H. Soininen, K. Ritchie, H. Blanché, J. Dartigues, C. Tzourio, I. Gut, C. Broeckhoven, A. Alpérovitch, M. Lathrop, P. Amouyel   +49 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Data submission for genome-wide association studies at the GWAS Catalog

, 2023

openalex   +1 more source