Results 161 to 170 of about 850,713 (297)

Genome-Wide Association Study of Body Fat Distribution identifies Novel Adiposity Loci and Sex-Specific Genetic Effects [PDF]

, 2017
Mathias Rask‐Andersen, Torgny Karlsson, Weronica E. Ek, Åsa Johansson   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Genome-wide association study and polygenic risk scores of eosinophilia in Taiwan. [PDF]

Clin Transl Immunology
Lu HF, Boon-Yong S, Yang CY, Wang JY, Chang YT, Tsai FJ.   +5 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Genome-wide association study of seed mineral nutrients in peas (Pisum sativum L.). [PDF]

Plant Genome
Sari H, Coyne CJ, Grusak MA, Valkov VA, Zhang Z, McGee RJ, Ma Y, Main D, Bandillo N, Hart J, Bourland BM, Uhdre R, Warburton ML.   +12 more
europepmc   +1 more source

Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study [PDF]

, 2020
Lina Cai, Eleanor Wheeler, Nicola D. Kerrison, Jian’an Luan, Panos Deloukas, Paul W. Franks, Pilar Amiano, Eva Ardanáz, Catalina Bonet, Guy Fagherazzi, Leif Groop, Rudolf Kaaks, José María Huerta, Giovanna Masala, Peter M. Nilsson, Kim Overvad, Valeria Pala, Salvatore Panico, Miguel Rodríguez‐Barranco, Olov Rolandsson, Carlotta Sacerdote, Matthias B. Schulze, Annemieke M. W. Spijkerman, Anne Tjønneland, ­Rosario ­Tumino, Yvonne T. van der Schouw, Stephen J. Sharp, Nita G. Forouhi, Elio Ríboli, Mark I. McCarthy, Inês Barroso, Claudia Langenberg, Nicholas J. Wareham   +32 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program. [PDF]

Diabetes
Raghavan S, Litkowski E, Jensen A, Charest B, Wang Z, Hui Q, Chen HC, Rhee MK, Leong A, Meigs JB, Lange L, Lange E, Reaven P, Hung A, Zhou J, Sun YV, Phillips LS, Million Veteran Program*.   +17 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Pod Dehiscence in Soybean: Genome Wide Association Study and Genomic Prediction. [PDF]

Plants (Basel)
Mazkirat S, Bulatova K, Didorenko S, Bastaubayeva S, Babissekova D, Khalbayeva S, Tukenov A, Yespembetova A, Saparbayeva N, Shavrukov Y.   +9 more
europepmc   +1 more source