Results 181 to 190 of about 674,070 (352)
LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico +12 morewiley +1 more sourceA genome-wide association study reveals cytokinin as a major component in the root defense responses againstRalstonia solanacearum [PDF]
, 2021 Alejandro Alonso-Díaz, Santosh B. Satbhai, Roger de Pedro‐Jové, Hannah M. Berry, Christian Göschl, Cristiana T. Argueso, Ondřej Novák, Wolfgang Busch, Marc Valls, Núria S. Coll +9 moreopenalex +1 more sourceATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs +11 morewiley +1 more sourceGenome-wide association study of blood pressure and hypertension
Nature Genetics, 2009 D. Levy, G. Ehret, K. Rice, G. Verwoert, L. Launer, A. Dehghan, N. Glazer, A. Morrison, Andrew D. Johnson, T. Aspelund, Y. Aulchenko, T. Lumley, A. Köttgen, R. Vasan, F. Rivadeneira, G. Eiriksdottir, Xiuqing Guo, D. Arking, G. Mitchell, F. Mattace-Raso, A. Smith, K. Taylor, R. Scharpf, Shih-Jen Hwang, E. Sijbrands, J. Bis, T. Harris, S. Ganesh, C. O’Donnell, A. Hofman, J. Rotter, J. Coresh, E. Benjamin, A. Uitterlinden, G. Heiss, C. Fox, J. Witteman, E. Boerwinkle, Thomas J. Wang, V. Gudnason, M. Larson, A. Chakravarti, B. Psaty, C. Duijn +43 moresemanticscholar +1 more sourceA subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli +3 morewiley +1 more sourceGenome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese
, 2015 Kewei Jiang, Yimin Sun, Cheng Wang, Jiafu Ji, Yaoping Li, Yingjiang Ye, Liang Lv, Yong Guo, Sutang Guo, Hai Li, Lianhai Zhang, Yanbing Zhou, Bo Jiang, Yonghong Ren, Youchun Xu, Xiongfei Yang, Hongxia Liu, Yirui Wang, Zhanlong Shen, Wenyan Qin, Peng Guo, Yuyang Jiang, Zhibin Hu, Hongbing Shen, Jing Cheng, Yinxue Yang, Shan Wang +26 moreopenalex +2 more sourcesGenome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
Nature Genetics, 2013 D. Harold, R. Abraham, P. Hollingworth, R. Sims, A. Gerrish, M. Hamshere, J. S. Pahwa, V. Moskvina, Kimberley Dowzell, Amy J. Williams, N. Jones, C. Thomas, A. Stretton, A. Morgan, S. Lovestone, J. Powell, P. Proitsi, Michelle K. Lupton, C. Brayne, D. Rubinsztein, M. Gill, B. Lawlor, A. Lynch, K. Morgan, K. Brown, P. Passmore, D. Craig, B. McGuinness, S. Todd, C. Holmes, D. Mann, A. Smith, S. Love, P. Kehoe, J. Hardy, S. Mead, N. Fox, M. Rossor, J. Collinge, W. Maier, F. Jessen, B. Schürmann, R. Heun, H. Bussche, I. Heuser, J. Kornhuber, J. Wiltfang, M. Dichgans, L. Frölich, H. Hampel, M. Hüll, D. Rujescu, A. Goate, J. Kauwe, Carlos Cruchaga, P. Nowotny, J. Morris, K. Mayo, K. Sleegers, K. Bettens, S. Engelborghs, P. Deyn, C. Broeckhoven, G. Livingston, N. Bass, H. Gurling, A. McQuillin, R. Gwilliam, P. Deloukas, A. Al-Chalabi, C. Shaw, M. Tsolaki, A. Singleton, R. Guerreiro, Thomas W. Mühleisen, M. Nöthen, S. Moebus, K. Jöckel, N. Klopp, H. Wichmann, M. Carrasquillo, V. Pankratz, S. Younkin, P. Holmans, M. O’Donovan, M. Owen, Julie Williams +86 moresemanticscholar +1 more sourceDeveloping evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking +43 morewiley +1 more sourceCommon genetic determinants of vitamin D insufficiency: a genome-wide association study
The Lancet, 2010 Thomas J. Wang, Feng Zhang, J. B. Richards, B. Kestenbaum, J. V. van Meurs, D. Berry, D. Kiel, E. Streeten, C. Ohlsson, Daniel L. Koller, L. Peltonen, J. Cooper, P. O’Reilly, D. Houston, N. Glazer, L. Vandenput, M. Peacock, J. Shi, F. Rivadeneira, M. McCarthy, Pouta Anneli, I. D. de Boer, M. Mangino, B. Kato, D. Smyth, S. Booth, P. Jacques, G. Burke, M. Goodarzi, C. Cheung, M. Wolf, K. Rice, D. Goltzman, N. Hidiroglou, M. Ladouceur, N. Wareham, L. Hocking, D. Hart, N. Arden, C. Cooper, S. Malik, W. Fraser, A. Hartikainen, G. Zhai, H. Macdonald, N. Forouhi, R. Loos, D. Reid, A. Hakim, E. Dennison, Yongmei Liu, C. Power, H. Stevens, Laitinen Jaana, R. Vasan, N. Soranzo, J. Bojunga, B. Psaty, M. Lorentzon, T. Foroud, T. Harris, A. Hofman, J. Jansson, J. Cauley, A. Uitterlinden, Q. Gibson, M. Järvelin, D. Karasik, D. Siscovick, M. Econs, S. Kritchevsky, J. Florez, J. Todd, J. Dupuis, E. Hyppönen, T. Spector +75 moresemanticscholar +1 more source
