Results 181 to 190 of about 1,051,148 (367)

Probability of detecting disease-associated single nucleotide polymorphisms in case-control genome-wide association studies [PDF]

, 2007
Mitchell H. Gail, Ruth M. Pfeiffer, William Wheeler, D. Pee   +3 more
openalex   +1 more source

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

Nature Network Boston, 2022
C. Tcheandjieu, Xiang Zhu, A. Hilliard, S. Clarke, V. Napolioni, Shining Ma, K. Lee, Huaying Fang, Fei Chen, Yingchang Lu, N. Tsao, S. Raghavan, S. Koyama, B. Gorman, M. Vujković, D. Klarin, M. Levin, Nasa Sinnott-Armstrong, G. Wojcik, M. Plomondon, T. Maddox, Stephen W. Waldo, A. Bick, S. Pyarajan, Jie Huang, Rebecca J Song, Y. Ho, S. Buyske, C. Kooperberg, J. Haessler, R. Loos, R. Do, M. Verbanck, K. Chaudhary, K. North, C. Avery, M. Graff, C. Haiman, L. Le Marchand, L. Wilkens, J. Bis, H. Leonard, Botong Shen, L. Lange, Ayush Giri, O. Dikilitas, I. Kullo, I. Stanaway, G. Jarvik, A. Gordon, S. Hebbring, B. Namjou, K. Kaufman, K. Ito, K. Ishigaki, Y. Kamatani, S. Verma, M. Ritchie, R. Kember, A. Baras, L. Lotta, S. Kathiresan, E. Hauser, Donald R Miller, Jennifer S. Lee, D. Saleheen, P. Reaven, Kelly Cho, J. Gaziano, P. Natarajan, J. Huffman, B. Voight, D. Rader, Kyong‐Mi Chang, J. Lynch, S. Damrauer, P. Wilson, Hua Tang, Yan V. Sun, P. Tsao, C. O’Donnell, T. Assimes   +81 more
semanticscholar   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Genome-wide association study to identify SNPs conferring risk of myocardial infarction and their functional analyses

, 2005
Kouichi Ozaki, Toshihiro Tanaka
openalex   +1 more source

Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap project [PDF]

, 2007
Yasuhito Nannya, Kenjiro Taura, Mineo Kurokawa, Shigeru Chiba, Seishi Ogawa   +4 more
openalex   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Deciphering the Genetic Basis of Allelopathy in japonica Rice Cultivated in Temperate Regions Using a Genome-Wide Association Study

Rice
Allelopathy has been considered as a natural method of weed control. Despite the nature of allelochemical compounds has been studied, little is known about the genetic basis underlying allelopathy.
Julia García-Romeral, Raúl Castanera, Josep Casacuberta, Concha Domingo   +3 more
doaj   +1 more source

Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases [PDF]

, 2007
Stephen F. Kingsmore, Ingrid Lindquist, Joann Mudge, William D. Beavis   +3 more
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source