Results 91 to 100 of about 4,660,063 (378)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Genomic insights into the alphaproteobacterium Georhizobium sp. MAB10 revealed a pathway of Mn(II) oxidation-coupled anoxygenic photoautotrophy: a novel understanding of the biotic process in deep-sea ferromanganese nodule formation

mBio
Under light conditions, Mn(II) facilitates the photoautotrophic growth of Georhizobium sp. MAB10, a strain derived from deep-sea ferromanganese nodules, along with the generation of dark Mn oxides (β-MnO2). This study investigated the genetic basis of Mn(
Xiuli Xu, Litao Zhang, Fuhang Song, Guoliang Zhang, Linlin Ma, Na Yang   +5 more
doaj   +1 more source

Phage vB_YenS_P400, a Novel Virulent Siphovirus of Yersinia enterocolitica Isolated from Deer

Microorganisms, 2022
Phage vB_YenS_P400 isolated from deer, is a virulent siphovirus of Y. enterocolitica, whose circularly permutated genome (46,585 bp) is not substantially related to any other phage deposited in public nucleotide databases.
Jens A. Hammerl, Andrea Barac, Claudia Jäckel, Julius Fuhrmann, Ashish Gadicherla, Stefan Hertwig   +5 more
doaj   +1 more source

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review [PDF]

, 2011
A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on ...
Akavia, Andrews, Baasiri, Chin, Dai, De Bie, Futreal, H.-U. Klein, Haverty, Hawkins, Hyman, Johnson, Kao, L. Lahti, M. Dugas, M. Schafer, McLendon, Menezes, Mullighan, Mullighan, Myllykangas, Olshen, Ortiz-Estevez, Phillips, Qin, S. Bicciato, Solvang, Soneson, Stranger, van Wieringen, van Wieringen   +30 more
core   +2 more sources

Commentary: The Materials Project: A materials genome approach to accelerating materials innovation

, 2013
Accelerating the discovery of advanced materials is essential for human welfare and sustainable, clean energy. In this paper, we introduce the Materials Project (www.materialsproject.org), a core program of the Materials Genome Initiative that uses high ...
Anubhav Jain, S. Ong, G. Hautier, Wei Chen, W. Richards, S. Dacek, S. Cholia, D. Gunter, D. Skinner, G. Ceder, K. Persson   +10 more
semanticscholar   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Draft Genome Sequence of the Biofilm-Forming Stenotrophomonas maltophilia Strain 53 [PDF]

, 2015
A clinical strain of Stenotrophomonas maltophilia (designated strain 53) was obtained, and a whole-genome sequence was generated. The subsequent draft whole-genome sequence demonstrated the presence of a number of genes encoding for proteins involved in ...
Akbar, Sirwan, Humphreys, Paul, Rout, Simon   +2 more
core   +1 more source

Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci [PDF]

, 2021
Feng‐Hua Lv, Yin-Hong Cao, Guangjian Liu, Ling-Yun Luo, Ran Lu, Mingjun Liu, Wenrong Li, Ping Zhou, Xinhua Wang, Min Shen, Lei Gao, Jingquan Yang, Hua Yang, Yonglin Yang, Changbin Liu, Pengcheng Wan, Yunsheng Zhang, Wenhui Pi, Yanling Ren, Zhiqiang Shen, Feng Wang, Yutao Wang, Jinquan Li, Hosein Salehian-Dehkordi, EEr Hehua, Yonggang Liu, Jianfei Chen, Jiankui Wang, Xuemei Deng, Ali Esmailizadeh, Mostafa Dehghani-Qanatqestani, Hadi Charati, Maryam Nosrati, Ondřej Štěpánek, Hossam E. Rushdi, Ingrid Olsaker, Ino Čurik, Neena Amatya Gorkhali, Samuel Rezende Paiva, Alexandre Rodrigues Caetano, Elena Ciani, Marcel Amills, C. Weimann, Georg Erhardt, Agraw Amane, Joram M. Mwacharo, Jianlin Han, Olivier Hanotte, Kathiravan Periasamy, Anna M. Johansson, Jón Hallsteinn Hallsson, Juha Kantanen, David W. Coltman, Michael W. Bruford, Johannes A. Lenstra, Meng-Hua Li   +55 more
openalex   +1 more source

Hormonal Genomics [PDF]

Endocrine Reviews, 2002
The availability of the human genomic sequence is changing the way in which biological questions are addressed. Based on the prediction of genes from nucleotide sequences, homologies among their encoded amino acids can be analyzed and used to place them in distinct families.
Chandra P, Leo, Sheau Yu, Hsu, Aaron J W, Hsueh   +2 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source