Results 91 to 100 of about 2,833,426 (370)

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

A Phylogenomic Supertree of Birds

Diversity, 2019
It has long been appreciated that analyses of genomic data (e.g., whole genome sequencing or sequence capture) have the potential to reveal the tree of life, but it remains challenging to move from sequence data to a clear understanding of evolutionary ...
Rebecca T. Kimball, Carl H. Oliveros, Ning Wang, Noor D. White, F. Keith Barker, Daniel J. Field, Daniel T. Ksepka, R. Terry Chesser, Robert G. Moyle, Michael J. Braun, Robb T. Brumfield, Brant C. Faircloth, Brian Tilston Smith, Edward L. Braun   +13 more
doaj   +1 more source

Genomic Sequence Resource of Kabatiella zeae, the Causative Pathogen of Corn Eyespot Disease

Molecular Plant-Microbe Interactions, 2021
Kabatiella zeae is the causative pathogen of corn eyespot disease, which is an important leaf disease that damages corn (Zea mays L.) worldwide. In this study, we provided an annotated draft of the assembled genome of the K. zeae field strain KZ1 through
Yafei Wang, Jinai Yao, Xinyao Xia, Zhiqiang Li, Shaoqun Zhou, Wende Liu, Hanxiang Wu   +6 more
doaj   +1 more source

GENOME TREES AND THE NATURE OF GENOME EVOLUTION [PDF]

Annual Review of Microbiology, 2005
Genome trees are a means to capture the overwhelming amount of phylogenetic information that is present in genomes. Different formalisms have been introduced to reconstruct genome trees on the basis of various aspects of the genome. On the basis of these aspects, we separate genome trees into five classes: (a) alignment-free trees based on statistic ...
Snel, B., Huynen, M.A., Dutilh, B.E.
openaire   +4 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Biosynthesis of Akaeolide and Lorneic Acids and Annotation of Type I Polyketide Synthase Gene Clusters in the Genome of Streptomyces sp. NPS554

Marine Drugs, 2015
The incorporation pattern of biosynthetic precursors into two structurally unique polyketides, akaeolide and lorneic acid A, was elucidated by feeding experiments with 13C-labeled precursors.
Tao Zhou, Hisayuki Komaki, Natsuko Ichikawa, Akira Hosoyama, Seizo Sato, Yasuhiro Igarashi   +5 more
doaj   +1 more source

Genome sequence-based species delimitation with confidence intervals and improved distance functions

BMC Bioinformatics, 2013
For the last 25 years species delimitation in prokaryotes (Archaea and Bacteria) was to a large extent based on DNA-DNA hybridization (DDH), a tedious lab procedure designed in the early 1970s that served its purpose astonishingly well in the absence of ...
Jan P. Meier-Kolthoff, Alexander F. Auch, H. Klenk, M. Göker   +3 more
semanticscholar   +1 more source

u-Genome: A Database on Genome Design in Unicellular Genomes

In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation, 2005
Unicellular eukaryotes were among the first ones to be selected for complete genome sequencing because of the small size of their genomes and their interactions with humans and a broad range of animals and plants. Currently, ten completely sequenced unicellular genome sequences have been publicly released and as the number of available unicellular ...
Sakharkar, K.R., Chaturvedi, I., Chow, V.T.K., Kwoh, C.K., Kangueane, P., Sakharkar, M.K.   +5 more
openaire   +2 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Nucleotide Distribution Patterns in Insect Genomes [PDF]

Systemix Reports 1, Feb 18, 2007, 2007
This work analyzed genome-wide nucleotide distribution patterns in ten insect genomes. Two internal measures were applied: (i) GC variation and (ii) third codon nucleotide preference. Although the genome size and overall GC level did not show any correlation with insect order, the internal measures usually displayed higher levels of consistency.
arxiv