Results 141 to 150 of about 4,660,063 (378)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Chromosome-Level Genome Assembly of Apoderus dimidiatus Voss (Coleoptera: Attelabidae): Insights into Evolution and Behavior

Insects
Attelabidae insects have attracted much attention due to their unique leaf rolling behavior before oviposition. However, the lack of genomic data makes it difficult to understand the molecular mechanism behind their behavior and their evolutionary ...
Meng Xie, Yuhao Yao, Yuling Feng, Lei Xie, Chuyang Mao, Jinwu He, Xueyan Li, Qingyong Ni   +7 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Selenobacteria-mediated Se transformation and uptake involving the unique genetic code

Frontiers in Plant Science
Selenium (Se) is a crucial micronutrient for human health. Plants are the primary source of Se for humans. Selenium in the soil serves as the primary source of Se for plants.
Qing Liao, Qing Liao, Qing Liao, Ao-Mei Li, Ao-Mei Li, Ao-Mei Li, Ying Xing, Ying Xing, Ying Xing, Pan-Xia Liang, Pan-Xia Liang, Pan-Xia Liang, Ze-Pu Jiang, Ze-Pu Jiang, Ze-Pu Jiang, Yong-Xian Liu, Yong-Xian Liu, Yong-Xian Liu, Dong-Liang Huang, Dong-Liang Huang, Dong-Liang Huang   +20 more
doaj   +1 more source

Nuclear Integrants of Organellar DNA Contribute to Genome Structure and Evolution in Plants [PDF]

, 2020
Guojun Zhang, Ran Dong, Lina Lan, Shufen Li, Wu‐Jun Gao, Hongxing Niu   +5 more
openalex   +1 more source

Improved vectors and genome-wide libraries for CRISPR screening

Nature Methods, 2014
Genome-wide, targeted loss-of-function pooled screens using the CRISPR (clustered regularly interspaced short palindrome repeats)–associated nuclease Cas9 in human and mouse cells provide an alternative screening system to RNA interference (RNAi) and ...
Neville E. Sanjana, Ophir Shalem, Feng Zhang   +2 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Biological and genomic characteristics of chicken-derived Riemerella anatipestifer in China

Frontiers in Microbiology
IntroductionRiemerella anatipestifer (R. anatipestifer) is a significant bacterial pathogen responsible for serositis, perihepatitis, and encephalitis in waterfowl. Although infections have been extensively reported in ducks, geese, and turkeys, cases in
Yuxia Zhang, Yuxia Zhang, Xiaoli Wang, Yongming Wang, Jiazhi Sun, Wenwen Dong, Wenwen Dong, Kai Meng, Kai Meng, Guiming Li, Guiming Li, Xiaoyuan Yuan, Xiaoyuan Yuan   +12 more
doaj   +1 more source

novoBreak: local assembly for breakpoint detection in cancer genomes. [PDF]

, 2017
We present novoBreak, a genome-wide local assembly algorithm that discovers somatic and germline structural variation breakpoints in whole-genome sequencing data.
Boutros, Paul, Chen, Junjie, Chen, Ken, Chen, Tenghui, Chong, Zechen, Ding, Li, Fan, Xian, Gao, Min, Lee, Anna Y, Ruan, Jue, Zhou, Wanding   +10 more
core  

The European Genome-phenome Archive in 2021

, 2021
Mallory Freeberg, Lauren A. Fromont, Teresa D’Altri, Anna Foix, Jorge Izquierdo Ciges, Aina Jené, Giselle Kerry, Mauricio Moldes, Roberto Ariosa, Saiveth Hernandez, Daniel Barrowdale, Marcos Casado Barbero, Dietmar Fernández‐Orth, Carles Garcia-Linares, Emilio García Ríos, Frédéric Haziza, Bela Juhasz, Oscar Martinez Llobet, Gemma Milla, Anand Mohan, Manuel Rueda, Aravind Sankar, Dona Shaju, Ashutosh Shimpi, Babita Singh, Coline Thomas, Sabela de la Torre, Umuthan Uyan, Claudia Vasallo, Paul Flicek, Roderic Guigó, Arcadi Navarro, Helen Parkinson, Thomas Keane, Jordi Rambla   +34 more
openalex   +1 more source