Results 131 to 140 of about 2,754,601 (316)

Selenobacteria-mediated Se transformation and uptake involving the unique genetic code

Frontiers in Plant Science
Selenium (Se) is a crucial micronutrient for human health. Plants are the primary source of Se for humans. Selenium in the soil serves as the primary source of Se for plants.
Qing Liao, Qing Liao, Qing Liao, Ao-Mei Li, Ao-Mei Li, Ao-Mei Li, Ying Xing, Ying Xing, Ying Xing, Pan-Xia Liang, Pan-Xia Liang, Pan-Xia Liang, Ze-Pu Jiang, Ze-Pu Jiang, Ze-Pu Jiang, Yong-Xian Liu, Yong-Xian Liu, Yong-Xian Liu, Dong-Liang Huang, Dong-Liang Huang, Dong-Liang Huang   +20 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Recent segmental and gene duplications in the mouse genome

, 2003
BioMed CentralBackground: The high quality of the mouse genome draft sequence and its ssociated annotations are an invaluable biological resource. Identifying recent duplications in the mouse genome, especially in regions containing genes, may highlight ...
Zhang, Junjun, Khaja, Razi, Wilson, Michael D, Scherer, Stephen W, MacDonald, Jeffrey R, Cheung, Joseph, Heng, Henry HQ, Koop, Ben F   +7 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

How central is the genome?

, 2007
review of The Music of Life: Biology Beyond the Genome, by Denis ...
Werner, Eric
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Aspergillus flavus NRRL 3357 wt AflW60-6 Resequencing genome sequencing

, 2016
Genome sequencing of Aspergillus flavus strain to assess the consequences of the elimination of the NHEJ DNA repair mechanisms on the genome stability and fungal ...
DOE Joint Genome Institute (17854997)
core  

Genome-wide transcriptome profiling reveals molecular response pathways of Trichoderma harzianum in response to salt stress

Frontiers in Microbiology
Trichoderma harzianum exhibits a strong biological control effect on many important plant pathogens, such as Fusarium oxysporum, Botrytis cinerea, and Meloidogyne. However, its biocontrol effectiveness is weakened or reduced under salt stress. The aim of
Qihong Yang, Qihong Yang, Zhenchuan Mao, Yali Hao, Shijie Zheng, Jianlong Zhao, Yan Li, Yuhong Yang, Bingyan Xie, Bingyan Xie, Jian Ling, Yanlin Li, Yanlin Li   +12 more
doaj   +1 more source

Genomics [PDF]

Plant Physiology, 1998
openaire   +2 more sources