Results 121 to 130 of about 4,524,973 (357)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

rtracklayer: an R package for interfacing with genome browsers

Bioinform., 2009
Summary: The rtracklayer package supports the integration of existing genome browsers with experimental data analyses performed in R. The user may (i) transfer annotation tracks to and from a genome browser and (ii) create and manipulate browser views to
Michael F. Lawrence, Robert Gentleman, Vincent J. Carey   +2 more
semanticscholar   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The influence of some tumor characteristics on the long-term survival of proximal colorectal cancer patients

Journal of Education, Health and Sport
The article is devoted to the study of survival in colorectal cancer and the influence of some common clinical factors on the life expectancy. Colorectal cancer (CRC) is an urgent problem of today and modern oncology, as the incidence of CRC is ...
D. Ratsiborskyi, A. Mashukov
doaj   +1 more source

A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life

Nature Biotechnology, 2018
Taxonomy is an organizing principle of biology and is ideally based on evolutionary relationships among organisms. Development of a robust bacterial taxonomy has been hindered by an inability to obtain most bacteria in pure culture and, to a lesser ...
Donovan H. Parks, Maria Chuvochina, D. Waite, Christian Rinke, Adam Skarshewski, Pierre-Alain Chaumeil, P. Hugenholtz   +6 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Short communication. Efficiency of AFLP markers and seed storage protein electrophoresis to study the phylogeny of some Hordeum species

Spanish Journal of Agricultural Research, 2013
This study is focused on reconstructing the phylogeny of 60 accessions representing ten species of the genus Hordeum based on amplified fragment length polymorphism (AFLP) markers and SDS-PAGE of seed storage proteins.
H. A. El Rabey, A. L. Al-Malki, K. O. Abulnaja, T. A. Kumosani, J. A. Khan   +4 more
doaj   +1 more source

Distribution and conservation of Banana Streak Virus (BSV) within banana Musa balbisiana genome : what impact on host and virus evolution ? [PDF]

, 2011
The nuclear genome of several plants isinvaded by numerous viral sequences. These integrations correspond to accidental events mainly resulting from illegitimate recombination of DNA viruses belonging to the family Caulimoviridae with plant DNA whereas ...
Chabannes, Matthieu, Duroy, Pierre-Olivier, Iskra Caruana, Marie-Line, Laboureau, Nathalie, Perrier, Xavier   +4 more
core  

Ecological genomics beyond genome reports

G3: Genes, Genomes, Genetics
With ongoing advances in sequencing and bioinformatics, the availability of reference genomes is spreading rapidly across the tree of life. Through genomics-enabled research, we are increasingly able to study the biology that we are interested in for the species that we care about. This expands the scope of our field.
Koen J F Verhoeven, Tanja Pyhäjärvi
openaire   +3 more sources

Perioperative genomics [PDF]

Best Practice & Research Clinical Anaesthesiology, 2011
Since the completion of the Human Genome Project 10 years ago, the world has witnessed an incredible progress in human genetics and genomics.(1) This progress was largely driven by the availability of better, faster and cheaper sequencing technology.(2) While it took more than 10 years and more than 1 billion dollars to complete the Human Genome ...
openaire   +2 more sources