Results 161 to 170 of about 3,743,554 (329)
Genome-wide identification and expression specificity analysis of the DNA methyltransferase gene family under adversity stresses in cotton [PDF]
, 2018 Xiaomin Yang +11 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
362. Cell-Specific Transcriptional Regulatory Domains Attract γ-Retroviral Integration in the Human Genome [PDF]
, 2009 openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Genome Assembly of Arctica islandica, the Longest-Lived Non-Colonial Animal Species
AnimalsWe report the first high-quality genome-wide assembly for Arctica islandica, the longest-lived non-colonial species, with a reported maximum life span of 507 years.
Glenn S. Gerhard +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
New bearings in pharmacotherapeutic strategies: Pharmacogenetics and gene therapy [PDF]
Vojnosanitetski Pregled, 2007 Grbović Leposava +4 more
doaj +1 more source